Protein Alignment CG33964 and METTL25

DIOPT Version :10

• Sequence 1: NP_001033941.1
• Gene: CG33964 / 3772719
• FlyBaseID: FBgn0053964
• Length: 484
• Species: Drosophila melanogaster
• Sequence 2: NP_115606.2
• Gene: METTL25 / 84190
• HGNCID: 26228
• Length: 603
• Species: Homo sapiens
• Alignment Length: 611
• Identity: 171/611 - (27%)
• Similarity: 268/611 - (43%)
• Gaps: 152/611 - (24%)

  Fly     9 LQRRLDGLLAFLNPHWDFVNCHMVNYLTDQHWDGFLS---ETLKSEI--AGKEDVALAIE----- 63
            |:.:|.|||.||.......|.|.|::.|:..|:..:.   ||:.:.:  :..|..||..|
Human    16 LRAKLQGLLQFLRDALSISNAHTVDFYTESVWEELVDLPPETVLAALRKSASETEALPSETRPLV 80

  Fly    64 DLFWKTDESERFPAWREFLGKSKQ----ERLSLHPK--------LLTSVEELIEG-QGNSTQ--- 112
            :..|:...:: ||  :.|...|::    |..:|..|        :.|..|:|:.. :||..|
Human    81 EAEWEAGMTD-FP--KIFCETSQKLVSVEAFALAAKYYSVQNLGICTPFEQLLVALRGNQNQRIG 142

  Fly   113 --LSIREFMSAKKCHEVDLTAVLVDQLVKNSG--QDCFIVDAGDGKGYLSSRLALQYGHRVLGID 173
              ....|||:.||.|||...:.|:..:....|  |   ::|.|.|||||||.|:|:||.:|.|||
Human   143 ENQKAVEFMNMKKSHEVQAMSELISSIADYYGIKQ---VIDLGSGKGYLSSFLSLKYGLKVYGID 204

  Fly   174 ANAANTENALNRNRKLQRAWNGLTERAELQVQGIT---PKRRSKKSPARESTKSAPALENYKTTA 235
            ::..||..|..|||||::.|.....::.|.|.|:.   .|.|..::..:....:.....|..|..
Human   205 SSNTNTHGAEERNRKLKKHWKLCHAQSRLDVNGLALKMAKERKVQNKVKNKADTEEVFNNSPTNQ 269

  Fly   236 KFITTEL---NFGALLAENF------TQFRPEDSPNIC--------------------------- 264
            :.:.|..   :|...:..|.      ...:|....|:|
Human   270 EKMPTSAILPDFSGSVISNIRNQMETLHSQPHQEENLCFENSFSLINLLPINAVEPTSSQQIPNR 334

  Fly   265 ----------------------------------------------LTGLHTCGNLAATCLQVFH 283
                                                          :.||||||:||...|::|.
Human   335 ETSEANKERRKMTSKSSESNIYSPLTSFITADSELHDIIKDLEDCLMVGLHTCGDLAPNTLRIFT 399

  Fly   284 AQTDCRLLCNVGCCYHLLRERYSQQEFFGNKSLMELQTDYGFPLSQYLRERQVRMGRNARMLAAQ 348
            :.::.:.:|:||||||||.|.      |.|:.....|..:|||:..||:|.:...||||||.|..
Human   400 SNSEIKGVCSVGCCYHLLSEE------FENQHKERTQEKWGFPMCHYLKEERWCCGRNARMSACL 458

  Fly   349 SIERTLDTKELPNVTLYYRALLEILVCRHAPELKNELQVGKV-RKFESFEEYIQKCATKLDAPWL 412
            ::||....:.||..:|:|||:|:.::.......|.:..|||: .|..||.:|:::...||...
Human   459 ALERVAAGQGLPTESLFYRAVLQDIIKDCYGITKCDRHVGKIYSKCSSFLDYVRRSLKKLGLD-- 521

  Fly   413 AAVEKEELQSLLQEYAVHKYF---------LDLFYLLRMSFAPVLESLILLDRLLYLKE---LGY 465
                    :|.|.|..:..|:         |:.|.:|::..||.:|:|||||||.||||   :.:
Human   522 --------ESKLPEKIIMNYYEKYKPRMNELEAFNMLKVVLAPCIETLILLDRLCYLKEQEDIAW 578

  Fly   466 ERSYLIDLFDPVISPRHFAIVSIKQQ 491
              |.|:.|||||.|||.:|::::|:|
Human   579 --SALVKLFDPVKSPRCYAVIALKKQ 602

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33964	NP_001033941.1	Methyltransf_32	122..304	CDD:379330	66/268 (25%)
METTL25	NP_115606.2	AdoMet_MTases	154..420	CDD:473071	66/268 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	326..352		0/25 (0%)