back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33964 and mettl25

DIOPT Version :9

Sequence 1:	NP_001033941.1	Gene:	CG33964 / 3772719	FlyBaseID:	FBgn0053964	Length:	484	Species:	Drosophila melanogaster
Sequence 2:	XP_073802771.1	Gene:	mettl25 / 678519	ZFINID:	ZDB-GENE-041210-90	Length:	594	Species:	Danio rerio

Alignment Length:	601	Identity:	168/601 - (27%)
Similarity:	264/601 - (43%)	Gaps:	144/601 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VVQLQRRLDGLLAFLNPHWDFVNCHMVNYLTDQHWDGFLS---ETLKSEIAGKEDVALAIED--- 64
            :|.:::::|.:..||:......|.|.|::.|...|..|:|   |.:...|:..:|...|:|:
Zfish     9 IVAVKKKIDEVKHFLSISLSISNAHTVDFYTRGVWSTFISVSPEDVLCAISSTQDSTGALEEKEN 73

  Fly    65 -LFWKTDESERFPAWREFLGKSKQERLSLHPKL--LTSVEELIE-----------GQGNSTQLSI 115
             .|...:.|::.......|..:|...|   |.|  ...:|||:.           ||.::..|:.
Zfish    74 TTFGFCNASKKLLDISALLRAAKAHCL---PGLGVCMQLEELMHNLRLMCGDTAAGQSSNKVLAP 135

  Fly   116 REFMSAKKCHEVDLTAVLVDQLVKNSGQDCF----IVDAGDGKGYLSSRLALQYGHRVLGIDANA 176
            .|||:.||.|||...:.:|..|.|     |.    ::|.|.|||||.|.|:::|..:|.|||::.
Zfish   136 DEFMNWKKAHEVQSMSEVVASLAK-----CCRVKQVIDVGSGKGYLCSYLSMRYNLQVFGIDSST 195

  Fly   177 ANTENALNRNRKLQR-------------------------------AWNGLTER-AELQVQG--- 206
            .||..|..|||||::                               :.|.:|:: .|.|.:.
Zfish   196 TNTHGAQERNRKLKKFSKAYQQHRFIENNCVQSNDESREHYNESDGSKNCITKQGVEAQTESSAL 260

  Fly   207 ---------------------------------------------ITP-----------KRRSKK 215
                                                         :.|           ||.:.:
Zfish   261 SQQVTRDLLASNNAAECPLDPSDSDSGSSFLSLLALDVIEDVSLRVHPSKLSAEERERRKRENLE 325

  Fly   216 SPARESTKSAPALENYKTTAKFITTELNFGALLAENFTQFRPEDSPNICLTGLHTCGNLAATCLQ 280
            ..|||..:.......:.....::|.|.....|:.|         ..|..|.||||||:||::.|:
Zfish   326 RKAREGKRKDSNSSLFSPLTSYVTAETELKTLITE---------LENAVLVGLHTCGDLASSSLR 381

  Fly   281 VFHAQTDCRLLCNVGCCYHLLRERYSQQEFFGNKSLMELQTD--YGFPLSQYLRERQVRMGRNAR 343
            :|.|:.:.|.:|:||||||||.|.:.|..       ....:|  .|||:||||:::....|||||
Zfish   382 MFRAKQELRAVCSVGCCYHLLSEEFDQDR-------PGCTSDGVCGFPMSQYLKDQACFCGRNAR 439

  Fly   344 MLAAQSIERTLDTKELPNVTLYYRALLEILVCRHAPELKNELQVGKV-RKFESFEEYIQKCATKL 407
            |.|..::||......||..:|:|||:|.:::..|....|:|.:||.| .|..||.:|:::...||
Zfish   440 MSACLALERVSAGGGLPMESLFYRAVLHVILQDHYDCFKSEKRVGNVYSKATSFADYVRRALRKL 504

  Fly   408 DAPWLAAVEKEELQSLLQEYAVHKYFLDLFYLLRMSFAPVLESLILLDRLLYLKEL-GYERSYLI 471
            |.. .:.:...::||....|......:..|.:|:::.||.:|.|||||||.||||. ....:.|:
Zfish   505 DLD-ESKLSDGDIQSYHDRYTPRMNEMVAFNMLKVTLAPCIEGLILLDRLCYLKEQENVSHAALV 568

  Fly   472 DLFDPVISPRHFAIVS 487
            .||||:.|||.:|:|:
Zfish   569 QLFDPLQSPRCYAVVA 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33964	NP_001033941.1	Methyltransf_32	122..304	CDD:379330	68/276 (25%)
mettl25	XP_073802771.1	None

Information from Original Tools:

Software error:

Can't use an undefined value as an ARRAY reference at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 1034.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	-	-
eggNOG	1	0.900	-	-
Hieranoid	0	0.000	Not matched by this tool.