DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33964 and ORC3

DIOPT Version :9

Sequence 1:	NP_001033941.1	Gene:	CG33964 / 3772719	FlyBaseID:	FBgn0053964	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_862820.1	Gene:	ORC3 / 23595	HGNCID:	8489	Length:	712	Species:	Homo sapiens

Alignment Length:	437	Identity:	99/437 - (22%)
Similarity:	173/437 - (39%)	Gaps:	88/437 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 KEDVALAIEDLFWK-----TDESERFPA----WREFLGKSKQERL--SLHPKLLTSVEELIEGQG 108
            |..::|.|||.|.|     .|...||..    |::.  ||:.|||  .|:..|..::.|.::...
Human    19 KRKISLPIEDYFNKGKNEPEDSKLRFETYQLIWQQM--KSENERLQEELNKNLFDNLIEFLQKSH 81

  Fly   109 NSTQLSIREFMSAKKCHEV--------------DLTAVLVDQLVKNS---------GQDCFIVDA 150
            :..|.:.|:.....|..|:              |||...:.:.::|:         .:||
Human    82 SGFQKNSRDLGGQIKLREIPTAALVLGVNVTDHDLTFGSLTEALQNNVTPYVVSLQAKDC----- 141

  Fly   151 GDGKGYLSSRLALQYGHRVLG--IDANAANTENALNRNRKLQRAWNGLTERAELQVQGITPKRRS 213
            .|.|.:|...::     :::.  :|..:...|:.....||...:.:.|:.......|...||..|
Human   142 PDMKHFLQKLIS-----QLMDCCVDIKSKEEESVHVTQRKTHYSMDSLSSWYMTVTQKTDPKMLS 201

  Fly   214 KKSPARESTKSAPALENYKTTAKFITTEL-NFGALLAENFTQFRPEDSPNICLTGLHTCGNLAAT 277
            ||.......:|.|.:...|....|.|..| :|..:.:::..:|     |.|.:.|:.|...:...
Human   202 KKRTTSSQWQSPPVVVILKDMESFATKVLQDFIIISSQHLHEF-----PLILIFGIATSPIIIHR 261

  Fly   278 CLQVFHAQTDCRLLC-----NVGCCYHLLRERYSQQEFFGNKSLMELQTDYGFPLSQYLRERQVR 337
            .|.  ||.:.  |||     ::.|..||....        :|.|:..|    ||..  :.|:.::
Human   262 LLP--HAVSS--LLCIELFQSLSCKEHLTTVL--------DKLLLTTQ----FPFK--INEKVLQ 308

  Fly   338 MGRNARMLAAQSIERTLDTKELPNVTLYYRALLEILVCRHAPELKNEL------QVGKVRKFESF 396
            :..|..:....|::..:...:|..:..:|...|.:|.| :.||.|..:      |...:|:..||
Human   309 VLTNIFLYHDFSVQNFIKGLQLSLLEHFYSQPLSVLCC-NLPEAKRRINFLSNNQCENIRRLPSF 372

  Fly   397 EEYIQKCATKLDAPWLAAVE--KEELQSLLQEYAVHKYFLDLFYLLR 441
            ..|::|.|::.....|....  |||.|.||:.  :|.|.::.|.:||
Human   373 RRYVEKQASEKQVALLTNERYLKEETQLLLEN--LHVYHMNYFLVLR 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33964	NP_001033941.1	Methyltransf_32	122..304	CDD:290402	43/212 (20%)
ORC3	NP_862820.1	ORC3_N	18..344	CDD:399784	75/359 (21%)
ORC3	NP_862820.1	ORC_WH_C	597..709	CDD:407969
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910