Protein Alignment CG33964 and Mettl25

DIOPT Version :10

• Sequence 1: NP_001033941.1
• Gene: CG33964 / 3772719
• FlyBaseID: FBgn0053964
• Length: 484
• Species: Drosophila melanogaster
• Sequence 2: XP_011241713.1
• Gene: Mettl25 / 216292
• MGIID: 3041259
• Length: 646
• Species: Mus musculus
• Alignment Length: 648
• Identity: 175/648 - (27%)
• Similarity: 266/648 - (41%)
• Gaps: 189/648 - (29%)

  Fly     9 LQRRLDGLLAFLNPHWDFVNCHMVNYLTDQHWDGFLSETLKSEIAGKEDVALAIEDLFWKTDESE 73
            |..:|.|||:||.......:.|.|::.|...|...:....:|.:|...:.|:..|..  :.:...
Mouse    19 LHDKLQGLLSFLRGALAISSAHTVDFYTKSVWQELVDLPPESVLAALRESAVEAEPR--EAETGS 81

  Fly    74 RFPAWREFLGKSKQERLSLHP-------------KLLTSVEELIEG-QGNSTQ-----LSIREFM 119
            .|....:...::.|:.||:..             .|.|..|:|:.. |||..|     :...|||
Mouse    82 GFTELPKIFCETSQKLLSVEAFARTAKHYSVQNLGLCTPSEQLLTALQGNKRQRVDENVKAIEFM 146

  Fly   120 SAKKCHEVDLTAVLVDQLVKNSGQDCFIVDAGDGKGYLSSRLALQYGHRVLGIDANAANTENALN 184
            :.||.|||...:.|:..:....|.. .|:|.|.|||||||.|:|:||..|.|||::..||..|..
Mouse   147 NTKKSHEVQAMSELICSIADYCGLK-QIIDVGSGKGYLSSFLSLKYGLNVYGIDSSNTNTHGAKE 210

  Fly   185 RNRKLQRAW-------------------------------------------------------- 193
            |||||::.|
Mouse   211 RNRKLKKHWSLYHPHSRADANGWASERPRELKVPKGVECKGDAESVQRSRLGNPDLSATDGLPDF 275

  Fly   194 -------------NGLTERAE-------------------------LQVQ-----GITPKRRSKK 215
                         |.|.:.||                         .|||     |:..:||:..
Mouse   276 SGSAISVIRKQQKNVLAQPAEEENLYFEDAFSLIDFLPVDAIEPTSSQVQNTEKSGLRKERRNTA 340

  Fly   216 SPARESTKSAPALENYKTTAKFITTELNFGALLAENFTQFRPEDSPNICLTGLHTCGNLAATCLQ 280
            |.||:|:       .|.....|||.:.....::         ||..:..:.||||||:||.:.|:
Mouse   341 SKARDSS-------IYSPLTSFITADSQLHDII---------EDLEDCLMVGLHTCGDLAPSTLR 389

  Fly   281 VFHAQTDCRLLCNVGCCYHLLRERYSQQEFFGNKSLMELQTDYGFPLSQYLRERQVRMGRNARML 345
            :|.::.:.:.:|:||||||||.|.:..|.  .::...|   ::|||:..||:|.:...||||||.
Mouse   390 IFTSKAEVKAVCSVGCCYHLLSEEFENQH--KDRCANE---NWGFPMCHYLKEERWCCGRNARMS 449

  Fly   346 AAQSIERTLDTKELPNVTLYYRALLEILVCRHAPELKNELQVGKV-RKFESFEEYIQKCATKL-- 407
            |..:::|....:.||..:|:|||:|:.::..:....|.|..|||: .|..||.||::....||
Mouse   450 ACLALQRVAVGQGLPTESLFYRAVLQNIIKDYYGISKCEQHVGKIYSKCSSFLEYVRMSLKKLGL 514

  Fly   408 -----------------------------------DAPWLAA--------VEKEELQSLLQEYAV 429
                                               |.|..:.        |.:|.:....:.|..
Mouse   515 DESKRHFQELQSVCCVLCSRWEQNLLDVFYVRLIYDRPGCSLCPMVGFLNVSEEIIMDYYENYKP 579

  Fly   430 HKYFLDLFYLLRMSFAPVLESLILLDRLLYLKEL-GYERSYLIDLFDPVISPRHFAIVSIKQQ 491
            ....|:.|.:|::..||.:|:|||||||.||||. |...|.|:.|||||.|||.:|::::|:|
Mouse   580 RMNELEAFNMLKVVLAPCIETLILLDRLCYLKEQDGVAWSALVKLFDPVQSPRCYAVIALKKQ 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33964	NP_001033941.1	Methyltransf_32	122..304	CDD:379330	73/280 (26%)
Mettl25	XP_011241713.1	AdoMet_MTases	149..413	CDD:473071	73/280 (26%)