DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bbx and Cic

DIOPT Version :9

Sequence 1:	NP_001027087.1	Gene:	bbx / 3772670	FlyBaseID:	FBgn0024251	Length:	769	Species:	Drosophila melanogaster
Sequence 2:	XP_011248998.1	Gene:	Cic / 71722	MGIID:	1918972	Length:	2512	Species:	Mus musculus

Alignment Length:	763	Identity:	181/763 - (23%)
Similarity:	263/763 - (34%)	Gaps:	255/763 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 PISRTKDKPSSAGEAEAKTLVREGESQGS--------PGKVAKSALGDPQPQRTEDQENAFRRIE 199
            |.|.......|...||:..:..|....|:        ||.|...:.| |.|..|         :.
Mouse   968 PASHPVASNQSKEPAESAAVAHEQPPGGTGGADPGRPPGAVCPESPG-PGPPLT---------LG 1022

  Fly   200 DVHNYAKLQDCSSDTDDEDDEEEDLDEE-EDDEEEA-------EIQVQLPVQQEVTRIRREAAEE 256
            .|.....|...:.:.......|..||.| |.|.::|       |||:.||..:..|:
Mouse  1023 GVDPGKSLPPTTEEEAPGPPGEPRLDSETESDHDDAFLSIMSPEIQLPLPPGKRRTQ-------- 1079

  Fly   257 HVDVDVVTVPQQEQDQYSHQVEPRQLQQDETADNTRPEHHARRPMNAFLIFCKRHRGIVKERYKT 321
                .:..:| :|:|..|        ::|..:.|.|.:.|.|||||||:||.||||.:|.:|:..
Mouse  1080 ----SLSALP-KERDSSS--------EKDGRSPNKREKDHIRRPMNAFMIFSKRHRALVHQRHPN 1131

  Fly   322 LENRAITKILGDWWAALDEQEKHCFTDLAQQNKDAFFNANPNFKW-------YKLPAPPL----- 374
            .:||.::||||:||.||..:||..:.|||.|.|:|.|.|:|::||       ....|.|.
Mouse  1132 QDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWCNKDRKKSSSEAKPASLGLA 1196

  Fly   375 --------RTLATRPSNASAGL-----------LIPSEDQPQQQVPTS-------LQVQWAERGE 413
                    |:::...:.|:.|:           |:.|:    .:||.|       |....|....
Mouse  1197 GGHKETRERSMSETGTAAAPGVSSELLSVAAQTLLSSD----TKVPGSGPCGAERLHAVGAPGSA 1257

  Fly   414 MPRAMLRPNYFKLADETQMGELSSLLQVQVQEKDFALQQVLSETSQFLSAHMPAGNTNGNGNKRS 478
            .|||........|    ..||:.|              |.|.|.:|.:|     |..:.:|.|.|
Mouse  1258 RPRAFSHSGVHSL----DGGEVDS--------------QALQELTQMVS-----GPASYSGPKPS 1299

  Fly   479 LQ-DNNSSNSSEEE----AASGSSPNKKVKSSRS-----------------CKGKIYQELV--NS 519
            .| ....|.::..|    |.||..|....::|||                 |:.:...:::  :|
Mouse  1300 PQYGAPGSFAAPGEGGTLATSGRPPLLPSRASRSQRAASEDMTSDEERMVICEEEGDDDVIADDS 1364

  Fly   520 GQLAAIAKKSKARL-----------PPAGNMG-GNFVDIP------------LD---AGPNTPPV 557
            .....|..|.|.|:           .|.||.| |..|..|            ||   .||..||.
Mouse  1365 FGTTDIDLKCKERVTDSESGDSSGEDPEGNKGFGRKVFSPVIRSSFTHCRPTLDPEPPGPPDPPA 1429

  Fly   558 S------PPERQGSSPDSMQKHIRSVSESSSSGFFDLEEKIKELPALSL-------DAYLQRKRS 609
            :      |.....|||.|....: |.|.|..||.|..:|..:...|:.|       .......::
Mouse  1430 AFSKGYGPTPSSSSSPASTSVSV-STSFSLGSGTFKTQESGQGSTAVPLRPPPPGAGGPATPSKA 1493

  Fly   610 TKKKKKFSGTKKQRNSNSTSGASATS-NVAAADAAAKG------AVPLSSEQHVRIKQQQLQAVG 667
            |:.....|.|.:::...|.....|.. :|.||..:..|      .:|.|.|
Mouse  1494 TRFPPTDSATFRRKRPESVGSLEAPGPSVIAAPPSGGGNLLQTLVLPPSKE-------------- 1544

  Fly   668 SQRRKARKESITRRDVSAIEQEVASILPLTINGSYYFNQSGAPKA------------VNAPVTSS 720
             .|...|..|             |...||..         |||.|            |..||:|:
Mouse  1545 -DREGTRVPS-------------APAPPLAY---------GAPAAPLCRPAATMVTNVVRPVSST 1586

  Fly   721 S---ASPPLSSNSSSSSSSLSSQAAFDVTSSTSDLLILAEVAANRTEL 765
            .   ||.|..::..:.:||                   .::|..|||:
Mouse  1587 PVPIASKPFPTSGRAEASS-------------------NDIAGARTEM 1615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bbx	NP_001027087.1	SOX-TCF_HMG-box	296..367	CDD:238684	39/77 (51%)
Cic	XP_011248998.1	DUF4819	253..342	CDD:406485
		PHA03247	<647..1061	CDD:223021	23/102 (23%)
		NHP6B	1063..1222	CDD:227935	57/179 (32%)
		SOX-TCF_HMG-box	1106..1177	CDD:238684	38/70 (54%)
		PHA03247	<1671..2172	CDD:223021
		PHA03247	<1979..2464	CDD:223021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2746
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900