Protein Alignment bbx and Cic

DIOPT Version :10

• Sequence 1: NP_001027087.1
• Gene: bbx / 3772670
• FlyBaseID: FBgn0024251
• Length: 769
• Species: Drosophila melanogaster
• Sequence 2: XP_011248998.1
• Gene: Cic / 71722
• MGIID: 1918972
• Length: 2512
• Species: Mus musculus
• Alignment Length: 763
• Identity: 181/763 - (23%)
• Similarity: 263/763 - (34%)
• Gaps: 255/763 - (33%)

  Fly   143 PISRTKDKPSSAGEAEAKTLVREGESQGS--------PGKVAKSALGDPQPQRTEDQENAFRRIE 199
            |.|.......|...||:..:..|....|:        ||.|...:.| |.|..|         :.
Mouse   968 PASHPVASNQSKEPAESAAVAHEQPPGGTGGADPGRPPGAVCPESPG-PGPPLT---------LG 1022

  Fly   200 DVHNYAKLQDCSSDTDDEDDEEEDLDEE-EDDEEEA-------EIQVQLPVQQEVTRIRREAAEE 256
            .|.....|...:.:.......|..||.| |.|.::|       |||:.||..:..|:
Mouse  1023 GVDPGKSLPPTTEEEAPGPPGEPRLDSETESDHDDAFLSIMSPEIQLPLPPGKRRTQ-------- 1079

  Fly   257 HVDVDVVTVPQQEQDQYSHQVEPRQLQQDETADNTRPEHHARRPMNAFLIFCKRHRGIVKERYKT 321
                .:..:| :|:|..|        ::|..:.|.|.:.|.|||||||:||.||||.:|.:|:..
Mouse  1080 ----SLSALP-KERDSSS--------EKDGRSPNKREKDHIRRPMNAFMIFSKRHRALVHQRHPN 1131

  Fly   322 LENRAITKILGDWWAALDEQEKHCFTDLAQQNKDAFFNANPNFKW-------YKLPAPPL----- 374
            .:||.::||||:||.||..:||..:.|||.|.|:|.|.|:|::||       ....|.|.
Mouse  1132 QDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWCNKDRKKSSSEAKPASLGLA 1196

  Fly   375 --------RTLATRPSNASAGL-----------LIPSEDQPQQQVPTS-------LQVQWAERGE 413
                    |:::...:.|:.|:           |:.|:    .:||.|       |....|....
Mouse  1197 GGHKETRERSMSETGTAAAPGVSSELLSVAAQTLLSSD----TKVPGSGPCGAERLHAVGAPGSA 1257

  Fly   414 MPRAMLRPNYFKLADETQMGELSSLLQVQVQEKDFALQQVLSETSQFLSAHMPAGNTNGNGNKRS 478
            .|||........|    ..||:.|              |.|.|.:|.:|     |..:.:|.|.|
Mouse  1258 RPRAFSHSGVHSL----DGGEVDS--------------QALQELTQMVS-----GPASYSGPKPS 1299

  Fly   479 LQ-DNNSSNSSEEE----AASGSSPNKKVKSSRS-----------------CKGKIYQELV--NS 519
            .| ....|.::..|    |.||..|....::|||                 |:.:...:::  :|
Mouse  1300 PQYGAPGSFAAPGEGGTLATSGRPPLLPSRASRSQRAASEDMTSDEERMVICEEEGDDDVIADDS 1364

  Fly   520 GQLAAIAKKSKARL-----------PPAGNMG-GNFVDIP------------LD---AGPNTPPV 557
            .....|..|.|.|:           .|.||.| |..|..|            ||   .||..||.
Mouse  1365 FGTTDIDLKCKERVTDSESGDSSGEDPEGNKGFGRKVFSPVIRSSFTHCRPTLDPEPPGPPDPPA 1429

  Fly   558 S------PPERQGSSPDSMQKHIRSVSESSSSGFFDLEEKIKELPALSL-------DAYLQRKRS 609
            :      |.....|||.|....: |.|.|..||.|..:|..:...|:.|       .......::
Mouse  1430 AFSKGYGPTPSSSSSPASTSVSV-STSFSLGSGTFKTQESGQGSTAVPLRPPPPGAGGPATPSKA 1493

  Fly   610 TKKKKKFSGTKKQRNSNSTSGASATS-NVAAADAAAKG------AVPLSSEQHVRIKQQQLQAVG 667
            |:.....|.|.:::...|.....|.. :|.||..:..|      .:|.|.|
Mouse  1494 TRFPPTDSATFRRKRPESVGSLEAPGPSVIAAPPSGGGNLLQTLVLPPSKE-------------- 1544

  Fly   668 SQRRKARKESITRRDVSAIEQEVASILPLTINGSYYFNQSGAPKA------------VNAPVTSS 720
             .|...|..|             |...||..         |||.|            |..||:|:
Mouse  1545 -DREGTRVPS-------------APAPPLAY---------GAPAAPLCRPAATMVTNVVRPVSST 1586

  Fly   721 S---ASPPLSSNSSSSSSSLSSQAAFDVTSSTSDLLILAEVAANRTEL 765
            .   ||.|..::..:.:||                   .::|..|||:
Mouse  1587 PVPIASKPFPTSGRAEASS-------------------NDIAGARTEM 1615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bbx	NP_001027087.1	HMG-box_HBP2	298..366	CDD:438805	36/67 (54%)
Cic	XP_011248998.1	DUF4819	253..342	CDD:465014
		PHA03247	<647..1061	CDD:223021	23/102 (23%)
		NHP6B	1063..1222	CDD:227935	57/179 (32%)
		HMG-box_CIC-like	1106..1183	CDD:438806	39/76 (51%)
		PHA03247	<1671..2172	CDD:223021
		PHA03247	<1979..2464	CDD:223021