Protein Alignment bbx and BBX

DIOPT Version :9

• Sequence 1: NP_001027087.1
• Gene: bbx / 3772670
• FlyBaseID: FBgn0024251
• Length: 769
• Species: Drosophila melanogaster
• Sequence 2: XP_024309412.1
• Gene: BBX / 56987
• HGNCID: 14422
• Length: 953
• Species: Homo sapiens
• Alignment Length: 649
• Identity: 171/649 - (26%)
• Similarity: 251/649 - (38%)
• Gaps: 204/649 - (31%)

  Fly   206 KLQDCSSDTDDEDDEEEDLDEEEDDEEEAEIQVQLPVQQEVTRIRREAAEEHVDVDVVTVPQQEQ 270
            ||.|.|.: ::|:|||||:|           :|||                 :..|
Human    47 KLLDFSEE-EEEEDEEEDID-----------KVQL-----------------LGAD--------- 73

  Fly   271 DQYSHQVEPRQLQQD--ETADNTRPEHHARRPMNAFLIFCKRHRGIVKERYKTLENRAITKILGD 333
                      .|:||  ||.|:..||..|||||||||:||||||.:|::.:..|:||..||||.|
Human    74 ----------GLEQDVGETEDDESPEQRARRPMNAFLLFCKRHRSLVRQEHPRLDNRGATKILAD 128

  Fly   334 WWAALDEQEKHCFTDLAQQNKDAFFNANPNFKW-------YKLPAP---PLRTLATRPSNASAGL 388
            |||.||.:||..:||:|::.||||..|||.:||       .|.|.|   |.:.|...||::|..|
Human   129 WWAVLDPKEKQKYTDMAKEYKDAFMKANPGYKWCPTTNKPVKSPTPTVNPRKKLWAFPSDSSRDL 193

  Fly   389 LIPSEDQPQQQVPTSLQVQWAERGEMPRAMLRPNYFKLADETQMGELSSLLQVQVQEKDFALQQV 453
            ..|.:               |:..|||:.     .|.:||.||||.||.||  ...|......:|
Human   194 PSPKK---------------AKTEEMPQL-----NFGMADPTQMGGLSMLL--LAGEHALGTPEV 236

  Fly   454 LSETSQ---------------FLSAHMPAGNTNGNGNKRSLQDNN-------SSNSSEEEAASGS 496
            .|.|.:               |..|.:.:..::.:.:.:..|.:.       |||:|:   ..|:
Human   237 SSGTCRPDVSESPELRQKSPLFQFAEISSSTSHSDASTKQCQTSALFQFAEISSNTSQ---LGGA 298

  Fly   497 SPNK--------------------KVKSSRSCKGK------------------IYQELVNSGQL- 522
            .|.|                    |::.|:..|.|                  |..|..:..:|
Human   299 EPVKRCGKSALFQLAEMCLASEGMKMEESKLIKAKESDGGRIKELEKGKEEKEIKMEKTDETRLQ 363

  Fly   523 --AAIAKKSKARLPPAGNMGGNFVDIPLDAGPNTPPVSPPE--RQGSSPDSMQKHIRSVSESSSS 583
              |...|.:|..|..:..: .||..:.:|.........|.|  ::....|....|....|.|:||
Human   364 KEAEFEKSAKENLRDSKEL-RNFEALQIDDIMAIKMEDPKEIRKEELEEDHKCSHFPDFSYSASS 427

  Fly   584 GFFDLEEKIKELPA-------------LSLDAYLQRKRSTKKKKKFSGTKKQRNSNST------- 628
            ...     |.::|:             :...|.|.:....|||||.|...:..|..||
Human   428 KII-----ISDVPSRKDHMCHPHGIMIIEDPAALNKPEKLKKKKKKSKMDRHGNDKSTPKKTCKK 487

  Fly   629 ---SGASATSNVAAADAAAKGAVPLSSEQHVRIKQQQLQAVG----------SQRRKARKESITR 680
               |.:...|.:...:|.|||...:........|:.:..:.|          .::.|:|::.:::
Human   488 RQSSESDIESVIYTIEAVAKGDWGIEKLGDTPRKKVRTSSSGKGSILDAKPPKKKVKSREKKMSK 552

  Fly   681 RDVSAIEQEVASILPLTINGSYYFNQSG-APKAVNA-PVT-SSSASPPLSSNSSSSSSSLSSQA 741
            ...|...:|  |..|..|:.|...|.|| .|:.:.| |:| ...|.||          |||.||
Human   553 EKSSDTTKE--SRPPDFISISASKNISGETPEGIKAEPLTPMEDALPP----------SLSGQA 604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bbx	NP_001027087.1	SOX-TCF_HMG-box	296..367	CDD:238684	43/77 (56%)
BBX	XP_024309412.1	SOX-TCF_HMG-box	91..162	CDD:238684	42/70 (60%)
		DUF2028	203..>335	CDD:312980	32/141 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152287
Domainoid	1	1.000	98	1.000	Domainoid score	I7204
eggNOG	1	0.900	-	-		E1_KOG2746
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	160	1.000	Inparanoid score	I4254
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0009740
OrthoInspector	1	1.000	-	-		oto90945
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13059
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8059
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	8.010