DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bbx and AgaP_AGAP003896

DIOPT Version :9

Sequence 1:	NP_001027087.1	Gene:	bbx / 3772670	FlyBaseID:	FBgn0024251	Length:	769	Species:	Drosophila melanogaster
Sequence 2:	XP_001230616.1	Gene:	AgaP_AGAP003896 / 4577125	VectorBaseID:	AGAP003896	Length:	556	Species:	Anopheles gambiae

Alignment Length:	576	Identity:	153/576 - (26%)
Similarity:	240/576 - (41%)	Gaps:	163/576 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 TEDQENAFRRIEDVHNY-AKLQDCSSDTDDEDDEEEDLDEEEDDEEEAEIQVQLPVQQEVTRIRR 251
            |:|....||::.  ||. .|.:.|.::...:|        ...:|...|:        .:|..|.
Mosquito    80 TQDLAVEFRQLS--HNVPIKTEHCIANNVGQD--------MATNETGGEL--------GITTARP 126

  Fly   252 EAAEEHVDVDVVTVPQQEQDQYSHQV--------------EPRQLQQDETADNTRPEHHARRPMN 302
            :|:|:.:.    ||.|:..:.::||.              ||.. :||..| ...|:...|||||
Mosquito   127 KASEQMLQ----TVDQKPYEAFTHQSITYVQTPAAAGEEREPED-EQDVGA-KASPKKEQRRPMN 185

  Fly   303 AFLIFCKRHRGIVKERYKTLENRAITKILGDWWAALDEQEKHCFTDLAQQNKDAFFNANPNFKWY 367
            ||||||||||.::|.|:.. |||||:..||.||..|..::|..|..|:::.|:.:.:.||||:|.
Mosquito   186 AFLIFCKRHRTMLKNRFPE-ENRAISIKLGKWWRMLTTEQKKPFQLLSKEYKNKYLSLNPNFRWC 249

  Fly   368 KLPAPPLRTLATRP-----SNASAGLLI------PSEDQPQQQVPTSLQVQWAERGEMPRAMLRP 421
            |.|..|.......|     .||:.||.:      ||..|..::   ||:   |....:..|..:|
Mosquito   250 KQPMVPATPSTPSPLVALAPNATNGLSLAAVRPEPSFVQDNRE---SLE---AAESLVQLAQGKP 308

  Fly   422 --NYFKLADETQMGELSSL-----LQVQVQEKDFALQQVLSETSQFLSAHMPAGNTNGNGNKRSL 479
              :.|:||||:.||.|::|     :..:...|:...:.  .:.:|.:...:||...:.:||.
Mosquito   309 LLSVFRLADESNMGSLNALCVGPNVGSRADNKEPTWKP--PKATQTVDRELPAPTPSISGNA--- 368

  Fly   480 QDNNSSNSSEEEAASG-SSPNKKVKSSRSCKGKIYQELVNSGQLAAIAKKSKARLPPAGNMGGNF 543
                   .:|..||.| |||    :::||||||.||||::.....|.|.::|.  .|...|..:.
Mosquito   369 -------VAEPIAAEGRSSP----RATRSCKGKKYQELMSRMYPNAHAPQTKR--SPGARMQKDN 420

  Fly   544 VDIP----LDAG---------PNTPPVSPPERQGSSPDSMQKHIRSVSESSSSGFFDLEEKIKEL 595
            ...|    :.||         .||   :.||....:.|::              ..:|:.||.:|
Mosquito   421 QKFPKPATVAAGGDDQTGFLYSNT---AMPELDPLAIDAL--------------MMELDSKISDL 468

  Fly   596 PALSLDAYLQRKRSTKKKKK-FSGTKKQ-----RNSNSTSGASATSNVAAADAAAKGAVPLSSEQ 654
            ||:::..:.....|.||:|| |:...||     |....::.||.|         |.|.|
Mosquito   469 PAMNVGDFCILLNSEKKRKKSFTKLPKQKLFLNREEQPSTAASVT---------ASGVV------ 518

  Fly   655 HVRIKQQQLQAVGSQRRKARKESITRRDVSAIEQEVASILPLTING-------SYY 703
                    ||:..|              ::.:...:|:|.....||       :||
Mosquito   519 --------LQSCNS--------------INGVAPPIATITQPATNGVDDSPLATYY 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bbx	NP_001027087.1	SOX-TCF_HMG-box	296..367	CDD:238684	35/70 (50%)
AgaP_AGAP003896	XP_001230616.1	SOX-TCF_HMG-box	179..249	CDD:238684	35/70 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2746
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	122	1.000	Inparanoid score	I7107
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm50926
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13538
TreeFam	1	0.960	-	-
	7	6.820