DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bbx and CIC

DIOPT Version :9

Sequence 1:	NP_001027087.1	Gene:	bbx / 3772670	FlyBaseID:	FBgn0024251	Length:	769	Species:	Drosophila melanogaster
Sequence 2:	NP_001291744.1	Gene:	CIC / 23152	HGNCID:	14214	Length:	2517	Species:	Homo sapiens

Alignment Length:	831	Identity:	179/831 - (21%)
Similarity:	268/831 - (32%)	Gaps:	304/831 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 NYTGRALKIVEKIPGASGVIATTSGNQGARSL------------------------EGYSPAAAS 101
            :||.......|.|.|..|.:.|   |...||:                        |...||:..
Human   913 SYTSHPAPKKEVIMGRPGTVWT---NVEPRSVAVFPWHSLVPFLAPSQPDPSVQPSEAQQPASHP 974

  Fly   102 YVSGLSRDFLISRELSQRSGEFLTAAAKMVSQMGASELRWLPISRTKDKPSSAGEAEAKTLVREG 166
            ..|..|::...|..::.......|.:|......||:    .|.|.....|...|..|:
Human   975 VASNQSKEPAESAAVAHERPPGGTGSADPERPPGAT----CPESPGPGPPHPLGVVES------- 1028

  Fly   167 ESQGSPGKVAKSALGDPQPQRTEDQENAFRRIEDVHNYAKLQDCSSDTDDEDDEEEDLDEEEDDE 231
             .:|.|....:.|.|.|...|.:                                   .|.|.|.
Human  1029 -GKGPPPTTEEEASGPPGEPRLD-----------------------------------SETESDH 1057

  Fly   232 EEA-------EIQVQLPVQQEVTRIRREAAEEHVDVDVVTVPQQEQDQYSHQVEPRQLQQDETAD 289
            ::|       |||:.||..:..|:            .:..:| :|:|..|        ::|..:.
Human  1058 DDAFLSIMSPEIQLPLPPGKRRTQ------------SLSALP-KERDSSS--------EKDGRSP 1101

  Fly   290 NTRPEHHARRPMNAFLIFCKRHRGIVKERYKTLENRAITKILGDWWAALDEQEKHCFTDLAQQNK 354
            |.|.:.|.|||||||:||.||||.:|.:|:...:||.::||||:||.||..:||..:.|||.|.|
Human  1102 NKREKDHIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVK 1166

  Fly   355 DAFFNANPNFKWYKLPAPPLRTLATRPSNASAGLLIPSEDQPQQQVPTSLQVQWAERGEMPRAML 419
            :|.|.|:|::||..         ..|..::|            :..||||.:....:....|:|
Human  1167 EAHFKAHPDWKWCN---------KDRKKSSS------------EAKPTSLGLAGGHKETRERSM- 1209

  Fly   420 RPNYFKLADET----QMGELSSLLQVQVQ------------------------------------ 444
                    .||    ..|..|.||.|..|
Human  1210 --------SETGTAAAPGVSSELLSVAAQTLLSSDTKAPGSSSCGAERLHTVGGPGSARPRAFSH 1266

  Fly   445 ---------EKDFALQQVLSETSQFLSAHMPAGNTNGNGNKRSLQDN-----NSSNSSEEEAASG 495
                     |.|   .|.|.|.:|.:|     |..:.:|.|.|.|..     .:.......||:|
Human  1267 SGVHSLDGGEVD---SQALQELTQMVS-----GPASYSGPKPSTQYGAPGPFAAPGEGGALAATG 1323

  Fly   496 SSPNKKVKSSRSCKGKIYQELVNSGQLAAIAK--------------------KSKARL------- 533
            ..|....::|||.:. ..:::.:..:...|.:                    |.|.|:
Human  1324 RPPLLPTRASRSQRA-ASEDMTSDEERMVICEEEGDDDVIADDGFGTTDIDLKCKERVTDSESGD 1387

  Fly   534 ----PPAGNMG-----------GNFVDI--PLD---AGPNTPPVSPPERQGSSPDSMQKHIRSVS 578
                .|.||.|           .:|...  |||   .||..|||:..:..||:|.|......|.|
Human  1388 SSGEDPEGNKGFGRKVFSPVIRSSFTHCRPPLDPEPPGPPDPPVAFGKGYGSAPSSSASSPASSS 1452

  Fly   579 ESSSSGFFDLEEKIKELPALSLDAYLQRKRSTKKKKKFSGTKKQRNSNSTSGASATSNVAAADAA 643
            .|:::.|             ||.               |||.|.:.|.  .|::|.........|
Human  1453 ASAATSF-------------SLG---------------SGTFKAQESG--QGSTAGPLRPPPPGA 1487

  Fly   644 AKGAVPLSSEQHVRIKQQQLQAVGSQRRKARKESITRRDVSAIEQEVASILPLTINGSYYFNQS- 707
            ...|.|..:.:.:.:.....       |:.|.||     |..:|....|::....:|.....|:
Human  1488 GGPATPSKATRFLPMDPATF-------RRKRPES-----VGGLEPPGPSVIAAPPSGGGNILQTL 1540

  Fly   708 -----------GAPKAVNAPVTSSSASPPLSSNSSSSSSSLSSQAAFDVTS 747
                       |..:..:||..|.:...|        ::.||..||..||:
Human  1541 VLPPNKEEQEGGGARVPSAPAPSLAYGAP--------AAPLSRPAATMVTN 1583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bbx	NP_001027087.1	SOX-TCF_HMG-box	296..367	CDD:238684	38/70 (54%)
CIC	NP_001291744.1	DUF4819	252..349	CDD:406485
		dnaA	871..>1046	CDD:237605	30/147 (20%)
		NHP6B	<1080..1224	CDD:227935	59/194 (30%)
		SOX-TCF_HMG-box	1108..1179	CDD:238684	38/70 (54%)
		PHA03247	<1765..2185	CDD:223021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2746
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900