DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bbx and sox18

DIOPT Version :9

Sequence 1:	NP_001027087.1	Gene:	bbx / 3772670	FlyBaseID:	FBgn0024251	Length:	769	Species:	Drosophila melanogaster
Sequence 2:	NP_001123409.1	Gene:	sox18 / 100170185	XenbaseID:	XB-GENE-483233	Length:	362	Species:	Xenopus tropicalis

Alignment Length:	360	Identity:	79/360 - (21%)
Similarity:	124/360 - (34%)	Gaps:	92/360 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   298 RRPMNAFLIFCKRHRGIVKERYKTLENRAITKILGDWWAALDEQEKHCFTDLAQQNKDAFFNANP 362
            |||||||:::.|..|..:.::...|.|..::|:||..|..|...||..|.:.|::.:......:|
Frog    69 RRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGQSWKNLSSAEKRPFVEEAERLRVQHLQDHP 133

  Fly   363 NFKWYKLPAPPLRTLATRPSNASAGLLIPSEDQPQQQVPTSLQVQWAERGEMPRAMLRPNYFKLA 427
            |:|:             ||........:...|      |:.|......||:   ||...::|:
Frog   134 NYKY-------------RPRRKKQAKKLKRVD------PSPLLRNEGYRGQ---AMANLSHFR-- 174

  Fly   428 DETQMGELSSLLQVQVQEKDFALQQVLSETSQ--FLSAHMPAGNTNGNGNKRSLQDNNSSNSSEE 490
            |...:|....|....:...:.:...|: |.|:  |...||                       .|
Frog   175 DLHPLGGSGDLESYGLPTPEMSPLDVV-EPSEPAFFPPHM-----------------------RE 215

  Fly   491 EAASGSSPNKKVKSSRSCKGKIYQELVNSGQLAAIAKKSKARLPPAGNMGG--------NFVDIP 547
            ||..|..             :.||..|:.||...:.:.|........:|||        .|...|
Frog   216 EADPGPF-------------RTYQHGVDFGQEKTLREISLPYSSSPSHMGGFLRTPTASAFYYNP 267

  Fly   548 LDAGPNTPP---VSPPERQGSSPDSMQKHIRSVSESSSSGFFDLEEKIKELPALSLDAYLQRKRS 609
            ....|...|   :|||. :..:.::|. |:   ..:...|.||..|         .|.||...|:
Frog   268 HGGSPACTPLGQLSPPP-EAPALEAMD-HL---GPAELWGDFDRNE---------FDQYLNMSRT 318

  Fly   610 TKKKKKFS----GTKKQRNSNSTSGASATSNVAAA 640
            ......|.    |..:......:|..||.|:.:.|
Frog   319 QGPGYPFPMSKLGAPRTIPCEESSLISALSDASTA 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bbx	NP_001027087.1	SOX-TCF_HMG-box	296..367	CDD:238684	23/68 (34%)
sox18	NP_001123409.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..68
		SOX-TCF_HMG-box	67..138	CDD:238684	23/81 (28%)
		Interaction with DNA. /evidence=ECO:0000250\|UniProtKB:P43680	70..83		7/12 (58%)
		Interaction with DNA. /evidence=ECO:0000250\|UniProtKB:P43680	94..106		4/11 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	129..159		8/48 (17%)
		Important for transcriptional activation. /evidence=ECO:0000250\|UniProtKB:P43680	149..209		14/71 (20%)
		Sox17_18_mid	173..222	CDD:371880	14/74 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910