Protein Alignment Hsp22 and Hspb7

DIOPT Version :10

• Sequence 1: NP_001027114.1
• Gene: Hsp22 / 3772576
• FlyBaseID: FBgn0001223
• Length: 174
• Species: Drosophila melanogaster
• Sequence 2: NP_113795.1
• Gene: Hspb7 / 50565
• RGDID: 62021
• Length: 169
• Species: Rattus norvegicus
• Alignment Length: 1234
• Identity: 231/1234 - (18%)
• Similarity: 395/1234 - (32%)
• Gaps: 430/1234 - (34%)

  Fly   135 RCYPSRGEEEEARYCGKQLLSPSSDNYQDSSD-------IESGSVSARHELFSCKSSAGSSPHDS 192
            ||  .|.::...|.......|...:...||.|       .|.||:.   :...|.|.|   |.|.
  Rat     6 RC--KRRKQANPRRTNVSNYSHVLEGQSDSDDEDKLHIVEEEGSLL---DGADCDSVA---PDDD 62

  Fly   193 PLRNNFSPLGRFVQHAKDLRSPTVCSFDNHQEQLLADNLVKPGQGVLEQEDHEEEEDKLQQPLDF 257
            | .....|.||               :|:.:|:.::|            || |...|.|.:.:..
  Rat    63 P-NGTADPDGR---------------WDDVKEECVSD------------ED-ERSRDALVEEMLQ 98

  Fly   258 ENNGRIWYPPPPEDENDDAESNYFHYDDEDDDIGDSATE----------FSLSSSFSSHIPTK-E 311
            :.:..:.:|..|:||..........:|  ::...||.::          :...:|...||..: |
  Rat    99 QGDTAVIFPEAPDDEPRQGTPETSGHD--ENGTPDSFSQLLTCPYCSRGYKRYTSLKEHIKYRHE 161

  Fly   312 KLGENSNEPL-------RTVVHDHFRALVAELLRGEELSPSDDGSAGEWLDIVTALAWQAANFVK 369
            |..:|.:..|       ||.:..|..|..|    |.|                          .:
  Rat   162 KSEDNFSCSLCSYTFAYRTQLDRHMTAHKA----GRE--------------------------QR 196

  Fly   370 PDTRAGGSMDPGNYVKIKCVASGNQNESILIRGIVCSKNITHKRMISQYKNPRVMLLAGSLEYQR 434
            ..|::||    |...|.||..              |.|...:|..:.::    :.:.:|...|
  Rat   197 HVTQSGG----GGNRKFKCTE--------------CGKAFKYKHHLKEH----LRIHSGEKPY-- 237

  Fly   435 VAGQLASFNTLLQQENEHMKAIIAKIESLRPNVLLVEKSASSYAQQYLLEKEISLV-LNVKRSLL 498
                          |..:.|...:              .:.||:.....:|.|.|: :|.:
  Rat   238 --------------ECSNCKKRFS--------------HSGSYSSHISSKKCIGLISVNGR---- 270

  Fly   499 DRIARCTGAVLCPSLD------SISTARLGHCELFRTERVLEQHEAGNQSNRKPSRTLMY----- 552
            .|.:..|||...|...      |..|||:...:.....:.|::.....|...:|   |.|
  Rat   271 PRPSPATGAAKTPQCSSPYLPTSSPTARVQVRDKLDNSKPLQEQLPLTQIKSEP---LDYEYKPV 332

  Fly   553 ------------FEGCPRRLGCTVVLRGSCRE--------------ELKKVKHVIQYAVFA-AYH 590
                        |:|     |....|:|:.:.              .|..:::|::.||.. ...
  Rat   333 VVAPSARGVNGMFQG-----GAAAPLQGAVQAVVLPTVGLVSPISINLGDLQNVLKVAVDGNVIR 392

  Fly   591 LSLETSFLADEGASLPKIRLKQPGMVRTASQRRIIDEGISL------------ITQSPTETDSQA 643
            ..||::....:.|.   ..:...|.:..|:|:.|  :.|||            |..|...:.:||
  Rat   393 QVLESTQAKGQQAG---TGIVGAGGIAQATQQVI--QAISLPILDQDGNAKIFINYSLDPSQAQA 452

  Fly   644 LLETAAHEDEHTAPMPEH-EVCESLCEDFDPTQIFPPSSEVETEQSDTLNGDFANNLVTRSYSSN 707
            :|::...|     |:..: |||:.        |..|....|:|.:..|            :.:.:
  Rat   453 VLQSPKKE-----PLGSNTEVCKG--------QKLPEDLTVKTNRDKT------------TLTVD 492

  Fly   708 QLNDLHEPTLCLSSEIPETPTQQPSGEED---NGRGEEENQ-----------LVNPQD-LPQHES 757
            :.:.||...|.           :..|:::   ||:..||..           |.|... |..:.:
  Rat   493 EKSMLHNDILL-----------KHCGKDEHRINGKNLEEKMDLEGLCPGQPPLKNLLSLLKAYFA 546

  Fly   758 FYEDDVSSEYFSAADSHQSILVSFSSRCVLKESVCERSRLLRIKFYGS-------------FDKP 809
            ...:....|....::|     ||..:..|.|  ..|:.:|.:|....|             .|..
  Rat   547 LNNEPTKEELAKISES-----VSLPAEVVKK--WFEKMQLGQISMDPSSPQHEEEQTTPVDLDGT 604

  Fly   810 LGRYLKDDLFDKTSS-------CRSCKELVDAHVLCYSHQNGNLTINVRRLPSMKLPGEQDGKIW 867
            .|...|.||.::.:|       |.|..|.:.|.|      ||     :..:|:...|
  Rat   605 KGASPKPDLDEQMNSEKQEERECCSPAEGIAASV------NG-----IESVPASPSP-------- 650

  Fly   868 MWHRCLRCAHVDGVPPATRRVVMSDAAWGLSFGKF-LELSFSNHATANRVASCGHS--------- 922
                 |..: .||..||..          |..|:. |:||....||...||| ||:
  Rat   651 -----LNLS-ADGPVPART----------LEEGEGPLDLSLPKSATTASVAS-GHANTVYSAQEE 698

  Fly   923 -LQRDCLRFYGFGNM---VAFF----RYSPINILTVLLPPSMLEFNSHPQQEWIR----TEAAEL 975
             |...|.:.....|.   .|.:    ..:||||:|..| |:::......|.:.:|    |:...|
  Rat   699 PLNLTCTKKELLSNASTNAAIYASQPSANPINIMTTQL-PTLVAITDQGQAQCLRALTTTKQTIL 762

  Fly   976 VGKMRTMYTEISDM-------------LNRMEEK--------SSLLEPEQSE------------- 1006
            :.::...||..|..             :|.::|:        :|:|| ||::
  Rat   763 IPQLTYSYTTTSSSPAGTDTPQKNILHVNGIKEEKQEMGSEATSILE-EQTDSDSGPTKKKMKRT 826

  Fly  1007 -----ACDLHSRIIGLIDQLVKEKDEYD-------DALQPIFE------ENLQIQGSLDILELNR 1053
                 ||||..:|......|::.|.|:.       ......|:      |:|::.......:.::
  Rat   827 ESGLYACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICSKAFKHKHHLIEHLRLHSGEKPYQCDK 891

  Fly  1054 LRRALMIGAHAWDHQLYLLN--SQLKKASVFKTGDDNAPRNPEMHDPPKIDRRMQEGSDERDEQS 1116
            ..:..   :|:..:..::.:  |..||    :.......:..|..|.|. :.:.|.||......|
  Rat   892 CGKRF---SHSGSYSQHMNHRYSYCKK----EAQGQGLGQGVEEEDNPG-EEQPQTGSTATSPPS 948

  Fly  1117 HTDSEANG-----DNKDPENIPSPGT----------SLSERIDSAWLGSFQNLEKAETIAETEG 1165
            |.||:..|     |..:.|:....|:          .:.|..|....|:.::.|:.|...:.||
  Rat   949 HLDSDERGSSTRDDESEEEDEMGSGSLVDEDEIQVVKIGEEGDEDDQGADEDQERMEEDGDEEG 1012

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp22	NP_001027114.1	metazoan_ACD	61..138	CDD:107247	2/2 (100%)
Hspb7	NP_113795.1	ACD_HspB7_like	72..152	CDD:107234	16/109 (15%)