DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hsp22 and HSPB2

DIOPT Version :10

Sequence 1:NP_001027114.1 Gene:Hsp22 / 3772576 FlyBaseID:FBgn0001223 Length:174 Species:Drosophila melanogaster
Sequence 2:NP_001532.1 Gene:HSPB2 / 3316 HGNCID:5247 Length:182 Species:Homo sapiens


Alignment Length:110 Identity:32/110 - (29%)
Similarity:51/110 - (46%) Gaps:7/110 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    64 YKLTLDVKDYS--ELKVKVLDESVVLVEGKSEQQEAEQGGYSSRHFLRRFVLPEGYEADKVTSTL 126
            ::..|||..::  |:.|:.:|.  :|.......|..::.|:.||.|.|.:|||...:..:|.:.|
Human    74 FQAFLDVSHFTPDEVTVRTVDN--LLEVSARHPQRLDRHGFVSREFCRTYVLPADVDPWRVRAAL 136

  Fly   127 SSDGVLTISVPNPPGVQETLKEREVTIEQTGEPAKKSAEEPNDKA 171
            |.||:|.:..|. .|.....:..||.|...  ||....||..:.|
Human   137 SHDGILNLEAPR-GGRHLDTEVNEVYISLL--PAPPDPEEEEEAA 178

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsp22NP_001027114.1 metazoan_ACD 61..138 CDD:107247 22/75 (29%)
HSPB2NP_001532.1 Crystallin <21..51 CDD:425732
alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins. 67..148 CDD:469641 22/75 (29%)
Blue background indicates that the domain is not in the aligned region.

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