DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp22 and Hspb1

DIOPT Version :9

Sequence 1:	NP_001027114.1	Gene:	Hsp22 / 3772576	FlyBaseID:	FBgn0001223	Length:	174	Species:	Drosophila melanogaster
Sequence 2:	NP_114176.4	Gene:	Hspb1 / 24471	RGDID:	61306	Length:	206	Species:	Rattus norvegicus

Alignment Length:	187	Identity:	53/187 - (28%)
Similarity:	79/187 - (42%)	Gaps:	53/187 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PMFWRMAEEMARMPRLSSPFHAFFHEPPVWSVALPRNWQQIARW---------------QEQEFA 54
            |...|:.::...:||.          |..||     .|...|.|               .....|
  Rat    24 PAHSRLFDQAFGVPRF----------PDEWS-----QWFSSAGWPGYVRPLPAATAEGPAAVTLA 73

  Fly    55 PPA---TVNK-------------DGYKLTLDVKDYS--ELKVKVLDESVVLVEGKSEQQEAEQGG 101
            .||   .:|:             |.::::|||..::  ||.||. .|.||.:.||.|:::.|. |
  Rat    74 APAFSRALNRQLSSGVSEIRQTADRWRVSLDVNHFAPEELTVKT-KEGVVEITGKHEERQDEH-G 136

  Fly   102 YSSRHFLRRFVLPEGYEADKVTSTLSSDGVLTISVPNPPGVQETLKEREVTIEQTGE 158
            |.||.|.|::.||.|.:...|:|:||.:|.||:..|.|..|.::   .|:||..|.|
  Rat   137 YISRCFTRKYTLPPGVDPTLVSSSLSPEGTLTVEAPLPKAVTQS---AEITIPVTFE 190

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp22	NP_001027114.1	IbpA	17..154	CDD:223149	48/169 (28%)
Hsp22	NP_001027114.1	metazoan_ACD	61..138	CDD:107247	31/91 (34%)
Hspb1	NP_114176.4	Interaction with TGFB1I1. /evidence=ECO:0000269\|PubMed:11546764	74..206		42/122 (34%)
Hspb1	NP_114176.4	ACD_HspB1_like	88..173	CDD:107230	31/86 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810