DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tyler and SLC25A40

DIOPT Version :9

Sequence 1:	NP_608327.2	Gene:	Tyler / 3772349	FlyBaseID:	FBgn0031038	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_061331.2	Gene:	SLC25A40 / 55972	HGNCID:	29680	Length:	338	Species:	Homo sapiens

Alignment Length:	418	Identity:	139/418 - (33%)
Similarity:	209/418 - (50%)	Gaps:	103/418 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 DPRYR------IKPMQQVVSALVGGLITTFVVTPLEVVKTRVQTQHAIRQRPTVSKLCYVYHNGL 96
            ||..|      :.|:||::::..|.::|:.:||||:|||.|:|.|:    .|.....|:||.|||
Human     2 DPETRGQEIIKVTPLQQMLASCTGAILTSVIVTPLDVVKIRLQAQN----NPLPKGKCFVYSNGL 62

  Fly    97 MTHVCRSSDIC--------VPKPGRDPQNLRPLRGAMDAFVKIVCTSGFSGLWAGLSPTLVSALP 153
            |.|:|    :|        ..|||.       .:|.:|||.||:...|...||:||.||||.|:|
Human    63 MDHLC----VCEEGGNKLWYKKPGN-------FQGTLDAFFKIIRNEGIKSLWSGLPPTLVMAVP 116

  Fly   154 STIIYFLTYEYIKNSLSHIYLVSQKFEESGMKDQVPGADGGDPLDQATRGINVSATAPVSTASLP 218
            :|:|||..|:.:...|                             ::..|.|.:.
Human   117 ATVIYFTCYDQLSALL-----------------------------RSKLGENETC---------- 142

  Fly   219 YYVPMASGICSRTIVVTAITPIEMVRIKMQSEYMTYAELWRVLRSLIRQHGILGLWRGWPPTVMR 283
              :|:.:||.:|...||.|:|:|::|.||||:..:|.||.|.:...:.:.|.:.|||||.|||:|
Human   143 --IPIVAGIVARFGAVTVISPLELIRTKMQSKKFSYVELHRFVSKKVSEDGWISLWRGWAPTVLR 205

  Fly   284 DAPFSGTYWAVYEAIKR----AFSVTEPTFLFSFLTGAISGAVATFVTMPFDLITTHTQIELGQD 344
            |.|||..||..||.:|:    ...:.||||:.:|.:||:||:.|...|:|||::.|..|.:|.
Human   206 DVPFSAMYWYNYEILKKWLCEKSGLYEPTFMINFTSGALSGSFAAVATLPFDVVKTQKQTQLW-- 268

  Fly   345 VLYEEIGAGTGAGTGTGAGARPKTPQSAVANSRPSVLSR---MRQIYRLQGVRGLYVGVMPRMLR 406
             .||                       :...|.|..:|.   |:.|....|..||:.|::||:::
Human   269 -TYE-----------------------SHKISMPLHMSTWIIMKNIVAKNGFSGLFSGLIPRLIK 309

  Fly   407 VVPACAIMISTFEYSKSFFFHYNLDLQE 434
            :.|||||||||:|:.|:||...|:..|:
Human   310 IAPACAIMISTYEFGKAFFQKQNVRRQQ 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tyler	NP_608327.2	Mito_carr	41..171	CDD:278578	53/143 (37%)
		Mito_carr	216..302	CDD:278578	37/89 (42%)
		Mito_carr	306..429	CDD:278578	43/125 (34%)
SLC25A40	NP_061331.2	Mito_carr	12..136	CDD:278578	52/167 (31%)
		Solcar 1	13..131		51/132 (39%)
		Solcar 2	139..223		38/95 (40%)
		Mito_carr	145..228	CDD:278578	36/82 (44%)
		Mito_carr	231..330	CDD:278578	43/124 (35%)
		Solcar 3	233..327		40/119 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	89	1.000	Domainoid score	I7833
eggNOG	1	0.900	-	-		E1_KOG0761
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	291	1.000	Inparanoid score	I2798
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53824
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001594
OrthoInspector	1	1.000	-	-		mtm8620
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45760
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1001
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.930