Protein Alignment Tyler and SLC25A40

DIOPT Version :8

• Sequence 1: NP_608327.2
• Gene: Tyler / 3772349
• FlyBaseID: FBgn0031038
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_061331.2
• Gene: SLC25A40 / 55972
• HGNCID: 29680
• Length: 338
• Species: Homo sapiens
• Alignment Length: 418
• Identity: 139/419 (33%)
• Similarity: 209/419 (50%)
• Gaps: 103/419 (25%)

  Fly    38 DPRYR------IKPMQQVVSALVGGLITTFVVTPLEVVKTRVQTQHAIRQRPTVSKLCYVYHNGL 96
            ||..|      :.|:||::::..|.::|:.:||||:|||.|:|.|:    .|.....|:||.|||
Human     2 DPETRGQEIIKVTPLQQMLASCTGAILTSVIVTPLDVVKIRLQAQN----NPLPKGKCFVYSNGL 62

  Fly    97 MTHVCRSSDIC--------VPKPGRDPQNLRPLRGAMDAFVKIVCTSGFSGLWAGLSPTLVSALP 153
            |.|:|    :|        ..|||.       .:|.:|||.||:...|...||:||.||||.|:|
Human    63 MDHLC----VCEEGGNKLWYKKPGN-------FQGTLDAFFKIIRNEGIKSLWSGLPPTLVMAVP 116

  Fly   154 STIIYFLTYEYIKNSLSHIYLVSQKFEESGMKDQVPGADGGDPLDQATRGINVSATAPVSTASLP 218
            :|:|||..|:.:...|                             ::..|.|.:.
Human   117 ATVIYFTCYDQLSALL-----------------------------RSKLGENETC---------- 142

  Fly   219 YYVPMASGICSRTIVVTAITPIEMVRIKMQSEYMTYAELWRVLRSLIRQHGILGLWRGWPPTVMR 283
              :|:.:||.:|...||.|:|:|::|.||||:..:|.||.|.:...:.:.|.:.|||||.|||:|
Human   143 --IPIVAGIVARFGAVTVISPLELIRTKMQSKKFSYVELHRFVSKKVSEDGWISLWRGWAPTVLR 205

  Fly   284 DAPFSGTYWAVYEAIKR----AFSVTEPTFLFSFLTGAISGAVATFVTMPFDLITTHTQIELGQD 344
            |.|||..||..||.:|:    ...:.||||:.:|.:||:||:.|...|:|||::.|..|.:|.
Human   206 DVPFSAMYWYNYEILKKWLCEKSGLYEPTFMINFTSGALSGSFAAVATLPFDVVKTQKQTQLW-- 268

  Fly   345 VLYEEIGAGTGAGTGTGAGARPKTPQSAVANSRPSVLSR---MRQIYRLQGVRGLYVGVMPRMLR 406
             .||                       :...|.|..:|.   |:.|....|..||:.|::||:::
Human   269 -TYE-----------------------SHKISMPLHMSTWIIMKNIVAKNGFSGLFSGLIPRLIK 309

  Fly   407 VVPACAIMISTFEYSKSFFFHYNLDLQE 434
            :.|||||||||:|:.|:||...|:..|:
Human   310 IAPACAIMISTYEFGKAFFQKQNVRRQQ 337

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tyler	NP_608327.2	Mito_carr	41..171	CDD:278578	53/144 (37%)
		Mito_carr	216..302	CDD:278578	37/90 (41%)
		Mito_carr	306..429	CDD:278578	43/126 (34%)
SLC25A40	NP_061331.2	Mito_carr	12..136	CDD:278578	52/168 (31%)
		Solcar 1	13..131		51/133 (38%)
		Solcar 2	139..223		38/96 (40%)
		Mito_carr	145..228	CDD:278578	36/83 (43%)
		Mito_carr	231..330	CDD:278578	43/125 (34%)
		Solcar 3	233..327		40/120 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	1	0.900				E1_KOG0761
Hieranoid	1	1.000
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000				FOG0001348
OrthoInspector	1	1.000				T130218
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100			O	PTHR45760
Phylome	1	0.910		0.800	Consistency score
RoundUp	0	0.000	Not matched by this tool.
TreeFam	1	0.960
User_Submission	0	0.000	Not matched by this tool.
	7	6.870