DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tyler and Slc25a40

DIOPT Version :9

Sequence 1:	NP_608327.2	Gene:	Tyler / 3772349	FlyBaseID:	FBgn0031038	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_001276524.1	Gene:	Slc25a40 / 319653	MGIID:	2442486	Length:	337	Species:	Mus musculus

Alignment Length:	405	Identity:	134/405 - (33%)
Similarity:	207/405 - (51%)	Gaps:	91/405 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 PRYRIKPMQQVVSALVGGLITTFVVTPLEVVKTRVQTQHAIRQRPTVSKLCYVYHNGLMTHVC-- 101
            |...:.|:||::::..|.::|:.:||||:|||.|:|.|:    .|.....|::|.||||.|:|
Mouse    10 PTIPVTPLQQMIASCTGAVLTSLMVTPLDVVKIRLQAQN----NPFPKGKCFLYSNGLMDHMCVC 70

  Fly   102 --RSSDICVPKPGRDPQNLRPLRGAMDAFVKIVCTSGFSGLWAGLSPTLVSALPSTIIYFLTYE- 163
              .|......|||.       .||.:|||:||:...|...||:||.||||.|:|:|:|||..||
Mouse    71 EEESKKAWYKKPGN-------FRGTLDAFLKILRNEGIKSLWSGLPPTLVMAIPATVIYFTCYEQ 128

  Fly   164 ---YIKNSLSHIYLVSQKFEESGMKDQVPGADGGDPLDQATRGINVSATAPVSTASLPYYVPMAS 225
               ::|..|.                           :..||                  :|:.:
Mouse   129 LSAFLKTKLG---------------------------ENETR------------------IPIVA 148

  Fly   226 GICSRTIVVTAITPIEMVRIKMQSEYMTYAELWRVLRSLIRQHGILGLWRGWPPTVMRDAPFSGT 290
            |:.:|...||.|:|:|::|.|:||:..:|.||::.:...:.:.|.:.||:||.||::||.|||..
Mouse   149 GVVARFGAVTVISPLELIRTKVQSKKFSYKELYQFVSMRVSEDGWISLWKGWAPTILRDVPFSAM 213

  Fly   291 YWAVYEAIKR----AFSVTEPTFLFSFLTGAISGAVATFVTMPFDLITTHTQIELGQDVLYEEIG 351
            ||..||.:||    ...:.||||:.:|.:||:||:.|...|:|||::.|..|.:|..:. |.:..
Mouse   214 YWYNYENLKRWLCEKSGLYEPTFMINFTSGALSGSFAAVATLPFDVVKTQKQTQLWTNE-YCKFP 277

  Fly   352 AGTGAGTGTGAGARPKTPQSAVANSRPSVLSRMRQIYRLQGVRGLYVGVMPRMLRVVPACAIMIS 416
            |.....|.|                      .|:.|...:|..||:.|::||::::|||||||||
Mouse   278 APLDMSTWT----------------------IMKNIVADKGFSGLFTGLIPRLVKIVPACAIMIS 320

  Fly   417 TFEYSKSFFFHYNLD 431
            ::|..||||...|::
Mouse   321 SYELGKSFFQKQNVE 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tyler	NP_608327.2	Mito_carr	41..171	CDD:278578	54/137 (39%)
		Mito_carr	216..302	CDD:278578	33/89 (37%)
		Mito_carr	306..429	CDD:278578	43/122 (35%)
Slc25a40	NP_001276524.1	Mito_carr	14..135	CDD:365909	52/131 (40%)
		Solcar 1	14..132		52/128 (41%)
		Solcar 2	140..224		34/101 (34%)
		Mito_carr	146..225	CDD:365909	32/78 (41%)
		Mito_carr	234..331	CDD:365909	42/119 (35%)
		Solcar 3	234..328		39/116 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	88	1.000	Domainoid score	I7902
eggNOG	1	0.900	-	-		E1_KOG0761
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	294	1.000	Inparanoid score	I2730
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53824
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001594
OrthoInspector	1	1.000	-	-		mtm8854
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45760
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1001
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.930