Protein Alignment CG10731 and DMAC2

DIOPT Version :8

• Sequence 1: NP_001027422.1
• Gene: CG10731 / 3772305
• FlyBaseID: FBgn0034081
• Length: 203
• Species: Drosophila melanogaster
• Sequence 2: NP_001161339.1
• Gene: DMAC2 / 55101
• HGNCID: 25496
• Length: 263
• Species: Homo sapiens
• Alignment Length: 214
• Identity: 58/214 - (27%)
• Similarity: 97/214 - (45%)
• Gaps: 32/214 - (14%)

  Fly    19 KDQRGIWGYVAVAFNQVDAER-------LSKVGANRLCAEW--------------IIKNGGGVRF 62
            |.:|.|..::...|..|:|.|       :.||........|              |:|.||.|:|
Human    42 KKKRTILQFLTNYFYDVEALRDYLLQREMYKVHEKNRSYTWLEKQHGPYGAGAFFILKQGGAVKF 106

  Fly    63 VESPSRLW---KDYNSLPGENTQFC---IKVVDASNSSIMKIGLEHLKDCRSIDTVIFHNCKHLE 121
            .:   :.|   ..|.....|...||   ::.|||.:..|...||::|...:.:.::....|.|::
Human   107 RD---KEWIRPDKYGHFSQEFWNFCEVPVEAVDAGDCDINYEGLDNLLRLKELQSLSLQRCCHVD 168

  Fly   122 NDGLEGLHHISSSLQRLQVSGCYNITDSGLAVIGELKNLRQLLIFDMIFVKNMEAVAASLKKQLP 186
            :..|..|:.::.|||.|.::||..|::.|||.:..|:|||:|.|.|:..|.|.......:::.||
Human   169 DWCLSRLYPLADSLQELSLAGCPRISERGLACLHHLQNLRRLDISDLPAVSNPGLTQILVEEMLP 233

  Fly   187 SCDIKATKM--GLTLKPKE 203
            :|::.....  ||...|:|
Human   234 NCEVVGVDWAEGLKSGPEE 252

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10731	NP_001027422.1	AMN1	<91..167	CDD:187754	24/75 (32%)
		leucine-rich repeat	109..134	CDD:275381	4/24 (17%)
		leucine-rich repeat	135..159	CDD:275381	10/23 (43%)
DMAC2	NP_001161339.1	leucine-rich repeat	132..155	CDD:275381	7/22 (32%)
		AMN1	140..>201	CDD:187754	18/60 (30%)
		leucine-rich repeat	156..181	CDD:275381	4/24 (17%)
		leucine-rich repeat	182..206	CDD:275381	10/23 (43%)
		leucine-rich repeat	207..227	CDD:275381	7/19 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	1	0.900				E1_KOG3864
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030		avgDist	Average_Evolutionary_Distance	R4273
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.930