DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HemK2 and n6amt1

DIOPT Version :9

Sequence 1:	NP_001027221.1	Gene:	HemK2 / 3771966	FlyBaseID:	FBgn0031454	Length:	224	Species:	Drosophila melanogaster
Sequence 2:	XP_002941300.2	Gene:	n6amt1 / 100380133	XenbaseID:	XB-GENE-5899961	Length:	215	Species:	Xenopus tropicalis

Alignment Length:	224	Identity:	86/224 - (38%)
Similarity:	125/224 - (55%)	Gaps:	16/224 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 METPYTDHLSPEDFEHVYEPAEDSFLLLDALEKDLEYLDRLQPSLCVELGSGSGVIITALAKKLA 65
            :.||...|:....|..||:||||:||||||||||.|.| :.:..:.:|:|.||||:...:|..:.
Frog     2 LPTPIYPHVGHGIFADVYDPAEDTFLLLDALEKDAEEL-KSRVGISLEVGCGSGVVSAFIASLIG 65

  Fly    66 GFSLCLATDINPKACNATRRTATRNGARLDSIRCSLADALRPR---SVDVLLFNPPYVVTSDEEL 127
            ..:..|.|||||.|...|..||..|...::.|...|...|.||   .:|:|:||||||||..||:
Frog    66 QKAWYLCTDINPVAAYCTLETARANQLHIEPIITDLVTGLLPRLQGHIDLLVFNPPYVVTPPEEV 130

  Fly   128 QTQQFDSHSESSTDRNLVFSWAGGQDGRRVTDILLKQLDDILSPRGVLYLLLLRENKPEEIIKYL 192
            .:...::            :||||::||.|.|.....:..:|||.|:.||::|:||.|:||::.:
Frog   131 GSHGIEA------------AWAGGKNGREVMDRFFPFVPKLLSPTGIFYLIVLKENNPDEILENM 183

  Fly   193 EGLQFRAVKFMERRIPGEHLCILKVTRYL 221
            ........|.:.|:...|:||:||..|.|
Frog   184 RMYGLIGSKVLCRQAGRENLCVLKFCRLL 212

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HemK2	NP_001027221.1	AdoMet_MTases	15..219	CDD:302624	80/206 (39%)
HemK2	NP_001027221.1	HemK	<15..193	CDD:225443	73/180 (41%)
n6amt1	XP_002941300.2	AdoMet_MTases	17..208	CDD:418430	79/203 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9541
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5637
Inparanoid	1	1.050	145	1.000	Inparanoid score	I4330
OMA	1	1.010	-	-		QHG54278
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004328
OrthoInspector	1	1.000	-	-		oto104824
Panther	1	1.100	-	-	LDO	PTHR45875
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3597
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.070