Protein Alignment Golgin245 and golg-4

DIOPT Version :9

• Sequence 1: NP_611787.2
• Gene: Golgin245 / 37702
• FlyBaseID: FBgn0034854
• Length: 1489
• Species: Drosophila melanogaster
• Sequence 2: NP_001355507.1
• Gene: golg-4 / 175445
• WormBaseID: WBGene00010306
• Length: 1642
• Species: Caenorhabditis elegans
• Alignment Length: 1762
• Identity: 401/1762 - (22%)
• Similarity: 744/1762 - (42%)
• Gaps: 415/1762 - (23%)

  Fly     1 MFANLKNKLI--------------EEVKASPSKFQQFANAAQAAVSSSSS-----TTPNSETNTS 46
            ||.||||:|.              |::.|...:::|..|...|...:|:|     |..:.||...
 Worm     1 MFKNLKNRLDNEAGKLKQSAQQYGEQLAAQVGQYRQAMNEQPAGSDASASISKRFTGESGETKAE 65

  Fly    47 NNENFFSITEEDTPQNSPYRIQKLPATSASALRGRSTQSLNGATSRTRKL-------SNSSMASD 104
            |..|       .:.::|...:.::|......|...||:|   .::|.|:.       ||.|..:.
 Worm    66 NPAN-------TSIESSSAIMSEIPEADLLGLGLSSTES---PSNRRRRSPSEDSIHSNESTLAA 120

  Fly   105 VSFRLPTYEAPAVYHLQSDLDETSSEFDDSASTARLDVITKDQLYDAYKKSLDRYHKYRCRYTDL 169
            :...:|...:.|:..:.||.:..:|:    |.:.|   .|.|..|::..|  .|...|:.:|.|.
 Worm   121 LLQSIPNAISSALETIPSDSESVASD----AFSVR---STNDPAYNSRLK--QRLATYKAKYRDA 176

  Fly   170 AKKYKELERDSSKARSVLVETQDKALRRISELREQCTLEQQAKAHL----------EEALRVEMD 224
            ..::.:|..|.:..|.:|..|||:.|:::.:||    ||::..|..          :|.|..:.:
 Worm   177 VHRHNKLVDDVNTTRKLLETTQDECLQKVEKLR----LEKRILAEKLSNSAGNGDGKEELEKKCE 237

  Fly   225 DMSCKMQAYQTKLQLLGENPENITAALERSGQQLESEQLIDLEESIGKSPLSTNGSSGVSDLQRL 289
            |....::..:.|::.|.::.:             |.:|||.::......|              .
 Worm   238 DYKRMLEQCKIKIKSLQQDKK-------------EQQQLITVDNDDSVDP--------------R 275

  Fly   290 LKERDEQLKSVTEKY-EAVRKQEEENVLLLAQTKQAIHTELELKDTEVRKLQEKLKQLESQRESH 353
            ::|.:::::...|:: ..:.:.::::.:.||.||..:|..||.||:|:.:.:.|...||.|....
 Worm   276 IREMEQRIQKTEEEWTNRINESDQQHAINLATTKAEMHAALENKDSEIEQWRRKCATLEQQDADA 340

  Fly   354 NNEVKEQFKKLQATKQEVDAKLMATEHLLNTLKESYAIKEQQVVTLEAQLEAIRVENEQKVKDLQ 418
            |....::.:|:||..:.::::   ...::..|.|:   |.|.|       :|:..|.|:|
 Worm   341 NQRWSDKVEKVQAMNKALESE---KNEMIEKLSEA---KAQGV-------KAVLEEEERK----- 387

  Fly   419 KQNEDRNTQASDSSEQLKKLQAAVQDAESQLLSKDQLLESLRSEQAAKEQQ-LKHLKEQLGKLKQ 482
                 |....:|.::::::|:...:....::.:....||:..|.:..:|:: ::.||.:|..:|.
 Worm   388 -----RTEMETDLNDEIERLKEETEKMRLEMSTYKVQLEAKESREFDEEREDVEALKLELNAVKS 447

  Fly   483 ENENYLDKLRENKKSSDSQTNEAQDQQKKLQAAK--------------DEAESKLLATEELLHSL 533
            ..::...::.||..|.::..:||   :|.|.|||              ::.|.:..|:|   |..
 Worm   448 TRDDLESRITENSSSFENYRSEA---EKTLAAAKAQFEKMVSECDKWREKYEERAAASE---HIA 506

  Fly   534 RNDYKAQE-----------EKVALLED------KLKTLSKENDVNVEKLHHINEQREAQSTDSQQ 581
            ..:::.||           ||.||.|.      |.:...||.:..|::|..:.::...:....|.
 Worm   507 TVEFETQETDAHRILEFEAEKKALAEKCEELTLKFEQADKEKNEMVQQLSRLQQEMLEKCDALQA 571

  Fly   582 KINELRAAKDEAEAKLLSTEHSLNALQAALSAKEEQAASLEQSLNALKTESEHSLQDL------R 640
            ::||.:|.::|.:||..........:|..|   ||....||....|.:.|.|...::.      :
 Worm   572 EVNEAKALREEIQAKYDDVTQKAERIQGEL---EESKKVLESEKQAFENEKEQEREEQLAKAMEK 633

  Fly   641 LHNDQ--LLEIVQRHQQNDWEAQLARAREELAAIQSQRELHALELEKSLEMERE-SVAALNSEKA 702
            |:::|  |.|:.::.:|::.|...||     .|||   ||    .||..|.|:| |.|....|..
 Worm   634 LNSEQNILDEVTKKLEQSEEEVLAAR-----GAIQ---EL----TEKLEESEKETSTAKTELEAV 686

  Fly   703 SQE-EQHRLKLEQLQREIQILQDQHANSE---SETVAALKGQLEALSQDLA----TSQASLLAKE 759
            |:: :.....|::....|:.::.|..|.|   .|.|..||.:||.:.::::    ..|..|.:..
 Worm   687 SKKLDSSETSLKEFSDMIEAMKIQLINCEKQKDEAVELLKQKLEEVEKNMSDVEVQKQLLLESTT 751

  Fly   760 KELKASGNKLNKIKKQHEQHQA------KSSDQSARLE-ALQSELADRLSH-SRQVESEKEELQA 816
            .|:|........:|||.|:.|:      |.::....|: ||:|:.:..:|. ::|:|:.|:||:|
 Worm   752 SEMKQHAEAAEIVKKQLEEAQSSIENLKKDAENERNLKTALESDESSAISEITKQMEAAKKELEA 816

  Fly   817 RVTGILEEIGTMQAQMQQVQDSHSELEREKRKLESRIESLQQEQVDSSAQDERTSAKLEEIQSEN 881
            ..    :|...::.||.::|..|:..:.:.:||:...| |:..::..|.:||:.:.:....:.||
 Worm   817 SE----KEKSELREQMDRLQKVHNAGQEDIQKLQKTWE-LEMAKIAKSTEDEKLAREQLAGELEN 876

  Fly   882 TKL----------------------AERNC-LLEEQTNHLESQLQAKQDEIGKIQAKLQQVLDEH 923
            .|.                      ||:.. :|:||....:|.|::.| |:...| |..::.:..
 Worm   877 AKEDLKVVEEEKHTGIQRAQGALDDAEKEVKVLKEQLERAQSALESSQ-ELASSQ-KADKIQELE 939

  Fly   924 SKLQNAQELMDHDHRTLQDKCDAYEKDKLLTKHTLDCLQSASEELHRVKANLDRELK-------- 980
            .:|||||:      |:.::...|.|..:.||. ||:...|.:|.|.:....||:||:
 Worm   940 KELQNAQK------RSSEELETANEMVRSLTA-TLENSNSETEILKQKLETLDKELQARQQTEKA 997

  Fly   981 -------------EQDQQLSELRERQREQEQQLKDQAERCAKLKAQ-------NSESETQLQATI 1025
                         |::||.::::..|.:..|...::.|:...:|.|       :|.:|..|:|.|
 Worm   998 LTEEINVLTTSLAEKEQQTAQIQNLQTQIYQMEVEKEEKVELVKVQLQQAAQSSSSAEEALRAEI 1062

  Fly  1026 SNLREQLDAYKQTEQGIQEKLQATNSSYTTQIATL----EARWSAANSDVERLHEAN----DALQ 1082
            ..|..:|.|.:|.:......|.|.......|:..|    |.:.......:::..:::    .||:
 Worm  1063 EQLEAKLKAVEQAKAEALNSLLAEKEHLQAQLHQLGVEKEEKLEMVKVQLQQAAQSSSSVEQALR 1127

  Fly  1083 LEMEQLKIKHGQEREEVKE-----SIAQKNRQVVELQEAMATRDR--------------QLQEKI 1128
            .|:|:|:.|. ||.||.|:     |:|:|.:|..::||..|...:              |||:..
 Worm  1128 AEIEKLEAKL-QEIEEEKKNALNASLAEKEQQTAQIQELQAQLHQLEVEKEEKLEMVKVQLQQAA 1191

  Fly  1129 EAS-----------EKL-AKFDEILIENEYLNKHTKQLEAELAESAELKEK-------------- 1167
            ::|           ||| ||..|  ||...:...:|: |.::.|.:.|.||
 Worm  1192 QSSSSVEQALRAEIEKLEAKLQE--IEKAKMQNSSKR-EQKVRELSNLNEKMRVEFIAKEKIISD 1253

  Fly  1168 ----LKSLQCELYVLQEKAEQHAVQMAEKETQSATATAEVSELKKAIEEQAVELTRQKE------ 1222
                |.::..||.|.:...|:..:...|.||:...|||:....|  :||..:..|..||
 Worm  1254 LRSELSTISTELVVQKATVEKTKMDFGELETREKRATADRENEK--MEEIRLRETFAKELETMGS 1316

  Fly  1223 ----HASFVTEQSDAVQKDLLQAQQQLHDKQIELAMSRDEQA-----LLQAEADGLRQEVICLKE 1278
                ..:...|...:.:|.:.:...|..:|..:...|:||.:     .|:|.|:..:.|
 Worm  1317 ALEVKETAYNELKASAEKKIAKLTSQFEEKLKKAQNSQDEASESRFKTLEASAEQAKLE------ 1375

  Fly  1279 HLSPSTDSDSLRSLNERL---QRELEDLKHKSAGAE---SNMQQEIEELQANNQQMAERINELET 1337
                  ....||:|.|.|   :.|:|:||.|...||   |:.:.|.|.|:...:::.:||..||.
 Worm  1376 ------SEQKLRALEELLKSSESEIEELKIKEISAEKDRSHWEVEKEMLEGEAKELTDRIEGLEA 1434

  Fly  1338 LRAGIQAQQLLASMAPKNVQ-EAAAAGEKAELESKLKEIMNEVQDVTNRNLFLEQKCENFLILEQ 1401
                 :.::|.|:...|.|: :..|.....||:.::|::.||:.|   :|...:...|....|:.
 Worm  1435 -----EVKKLTAANETKAVKADTDARKVVRELQKEVKQLYNELND---KNQQFDMVQEELTRLKT 1491

  Fly  1402 SNE-----RLKLQN-----------------AKLSRQLDETLV---------------------- 1422
            |.|     :|::|.                 |.|.::||.:|.
 Worm  1492 SKETAENGQLQVQKQMDEEDRRSEFSFKEEIASLKQKLDASLTEADDLRMQVSRNEKTPRSNGNA 1556

  Fly  1423 ------SMQ-HSEAVPANTEFEYLRNIMFQYLTGNTN----NETLVKVISAVLKFSPQQAQVALE 1476
                  ||: |..|.||  |.|||||::::|:|...:    :.||.:||..|.:|...|.:..:.
 Worm  1557 STGRTKSMELHGIADPA--EAEYLRNVLYRYMTNRESLGKESVTLARVIGTVARFDESQMKNVIS 1619

  Fly  1477 KEHQRRS 1483
            .|..|::
 Worm  1620 SEESRQA 1626

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Golgin245	NP_611787.2	Smc	286..1089	CDD:224117	207/919 (23%)
		Phage_GPO	<306..421	CDD:301727	27/114 (24%)
		Smc	737..1442	CDD:224117	210/897 (23%)
		MIT_CorA-like	<1244..>1333	CDD:294313	26/99 (26%)
		Grip	1433..1477	CDD:197860	15/47 (32%)
golg-4	NP_001355507.1	DUF3584	207..>884	CDD:378817	166/756 (22%)
		SMC_prok_B	577..1442	CDD:274008	219/916 (24%)
		SH3_and_anchor	<1444..1549	CDD:275056	21/107 (20%)
		Grip	1572..1620	CDD:197860	17/49 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	241	1.000	Domainoid score	I1245
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	247	1.000	Inparanoid score	I2039
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007308
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100282
Panther	1	1.100	-	-	LDO	PTHR19327
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.050