DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp59C and zgc:103670

DIOPT Version :9

Sequence 1:	NP_611759.1	Gene:	Klp59C / 37671	FlyBaseID:	FBgn0034824	Length:	626	Species:	Drosophila melanogaster
Sequence 2:	XP_005166887.1	Gene:	zgc:103670 / 447926	ZFINID:	ZDB-GENE-040912-111	Length:	747	Species:	Danio rerio

Alignment Length:	573	Identity:	290/573 - (50%)
Similarity:	361/573 - (63%)	Gaps:	71/573 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 IRRSDGRVHLAEIIKLEGGDSKLITVEWPEGHTVRGKELPLELVVLMNPHIFDSPRCSGGNAASA 76
            |:|||||:|.|.:..| ..|::.:||||.|....:|||:.||.:..:||.:......|.......
Zfish    16 IKRSDGRIHQAMVTSL-NEDNESVTVEWIENGDTKGKEIDLECIFSLNPDVAPEEEISLSPVTPP 79

  Fly    77 NQTASISPRSMK--------QRIATG------------------------------SLSPVLATA 103
            ..|    |.|:|        :.||.|                              ...|..|..
Zfish    80 PPT----PSSVKVNKIPKNRRTIAPGRSEIPSRDNRVGSTRARPAQQLQQQQQQQPQPQPESAPP 140

  Fly   104 PPRQQTAPPV-----------------REDEVVHQAERMRKERERRREAQARTRLDREQGKNEDP 151
            ||.||.:.|.                 |:...|.:.|:::::|||||..|...|..|.|  ..|.
Zfish   141 PPAQQPSQPTQSQTQSQLTQQQQQNARRKSNCVKEVEKLQEKRERRRLQQQELREKRAQ--EVDT 203

  Fly   152 GNPNWEVARMIRLQREQMESQRVRSGTTNERINCHQIMVCVRKRPLRRKELADREQDVVSIPSKH 216
            ..||:|:.:|||..|..::   .|..||.:.|..|:|.||||||||.:|||:.::.||::||||.
Zfish   204 TIPNYEILQMIRDFRGSLD---YRPLTTTDLIEEHRICVCVRKRPLNKKELSVKDLDVITIPSKD 265

  Fly   217 TLVVHEPRKHVNLVKFLENHSFRFDYVFDEECSNATVYEFTARPLIKHIFDGGMATCFAYGQTGS 281
            .::||||::.|:|.::|||.:|||||.||:..:|..||.||||||::.|||.|||||||||||||
Zfish   266 VVMVHEPKQKVDLTRYLENQTFRFDYAFDDSTTNEMVYRFTARPLVETIFDRGMATCFAYGQTGS 330

  Fly   282 GKTYTMGGQFPGRHQSSMDGIYAMAAKDVFSTLKTVPYNKLNLKVYCSFFEIYGTRVFDLLMPGK 346
            |||:||||.|.|::|....||||:||:|||..||...|.||:|:||.:|||||..:||||| ..|
Zfish   331 GKTHTMGGDFSGKNQDCSKGIYALAARDVFLMLKKPNYKKLDLQVYATFFEIYSGKVFDLL-NRK 394

  Fly   347 PQLRVLEDRNQQVQVVGLTQNPVQNTAEVLDLLELGNSVRTSGHTSANSKSSRSHAVFQIVLRSA 411
            .:||||||..||||||||.:..|:.|.:||.|:|:|||.||||.||||:.||||||||||:||..
Zfish   395 AKLRVLEDGKQQVQVVGLQEREVKCTEDVLKLIEIGNSCRTSGQTSANAHSSRSHAVFQIILRRK 459

  Fly   412 AGEKLHGKFSLIDLAGNERGADNSSADRQTRLEGSEINKSLLVLKECIRALGRQSSHLPFRGSKL 476
            .  |:|||||||||||||||||.|||||||||||:|||||||.||||||||||...|.|||.|||
Zfish   460 G--KMHGKFSLIDLAGNERGADTSSADRQTRLEGAEINKSLLALKECIRALGRNKPHTPFRASKL 522

  Fly   477 TQVLRDSFIGGKKVKTCMIAMISPCLHSVEHTLNTLRYADRVKE--LSVESIP 527
            ||||||||| |:..:|||||.|||.:.|.|:||||||||:||||  :|...||
Zfish   523 TQVLRDSFI-GENSRTCMIATISPGMASCENTLNTLRYANRVKEFGISPSDIP 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp59C	NP_611759.1	KISc_KIF2_like	187..519	CDD:276818	222/331 (67%)
Klp59C	NP_611759.1	Kinesin	193..520	CDD:278646	219/326 (67%)
zgc:103670	XP_005166887.1	KISc	236..572	CDD:214526	226/339 (67%)
zgc:103670	XP_005166887.1	KISc_KIF2_like	236..564	CDD:276818	222/331 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0246
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D202066at33208
OrthoFinder	1	1.000	-	-		FOG0001531
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100492
Panther	1	1.100	-	-	O	PTHR24115
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3177
SonicParanoid	1	1.000	-	-		X866
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.810