DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp59C and RGD1559908

DIOPT Version :9

Sequence 1:	NP_611759.1	Gene:	Klp59C / 37671	FlyBaseID:	FBgn0034824	Length:	626	Species:	Drosophila melanogaster
Sequence 2:	XP_038952347.1	Gene:	RGD1559908 / 364670	RGDID:	1559908	Length:	557	Species:	Rattus norvegicus

Alignment Length:	563	Identity:	283/563 - (50%)
Similarity:	362/563 - (64%)	Gaps:	39/563 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KLSIEQKIFIRRSDGRVHLAEIIKLEGGDSKLITVEWPEGHTVRGKELPLELVVLMNPHIFDSPR 67
            |:.|...:.|:|||||:|.|.:..| ..|::.:||||.|....:|||:.||.:..:||.:.....
  Rat     8 KIQIGIYVEIKRSDGRIHQAMVTSL-NEDNESVTVEWIENGDTKGKEIDLESIFSLNPDLVPDED 71

  Fly    68 CSGGNAASANQTASISPRSMKQRIATGSLSPVLATAPPR----------------------QQTA 110
            ...........::|...:.:|.|....|:.   ...|||                      ||.|
  Rat    72 IEPSPEIPPPSSSSKVNKIVKNRRTVASIK---NDPPPRDNRVVGSARARPSQLPEQSSSAQQNA 133

  Fly   111 PPVREDEVVHQAERMRKERERRREAQARTRLDREQGKNEDPGNPNWEVARMIRLQREQMESQRVR 175
            .  |:...|.:.|:::::||:||..|...|..|.|  :.|..|||:|:..|||..|..::   .|
  Rat   134 R--RKSNCVKEVEKLQEKREKRRLQQQELREKRAQ--DVDATNPNYEIMCMIRDFRGSLD---YR 191

  Fly   176 SGTTNERINCHQIMVCVRKRPLRRKELADREQDVVSIPSKHTLVVHEPRKHVNLVKFLENHSFRF 240
            ..||.:.|:.|:|.||||||||.:||...::.||::||||..::||||::.|:|.::|||.:|||
  Rat   192 PLTTADPIDEHRICVCVRKRPLNKKETQMKDLDVITIPSKDVVMVHEPKQKVDLTRYLENQTFRF 256

  Fly   241 DYVFDEECSNATVYEFTARPLIKHIFDGGMATCFAYGQTGSGKTYTMGGQFPGRHQSSMDGIYAM 305
            ||.||:...|..||.||||||::.||:.||||||||||||||||:||||.|.|::|....||||:
  Rat   257 DYAFDDSAPNEMVYRFTARPLVETIFERGMATCFAYGQTGSGKTHTMGGDFSGKNQDCSKGIYAL 321

  Fly   306 AAKDVFSTLKTVPYNKLNLKVYCSFFEIYGTRVFDLLMPGKPQLRVLEDRNQQVQVVGLTQNPVQ 370
            ||:|||..||...|.||.|:||.:|||||..:||||| ..|.:||||||..||||||||.:..|:
  Rat   322 AARDVFLMLKKPNYKKLELQVYATFFEIYSGKVFDLL-NRKTKLRVLEDGKQQVQVVGLQEREVK 385

  Fly   371 NTAEVLDLLELGNSVRTSGHTSANSKSSRSHAVFQIVLRSAAGEKLHGKFSLIDLAGNERGADNS 435
            ...:||.|:::|||.||||.||||:.||||||||||:||...  |||||||||||||||||||.|
  Rat   386 YVEDVLKLIDIGNSCRTSGQTSANAHSSRSHAVFQIILRRKG--KLHGKFSLIDLAGNERGADMS 448

  Fly   436 SADRQTRLEGSEINKSLLVLKECIRALGRQSSHLPFRGSKLTQVLRDSFIGGKKVKTCMIAMISP 500
            ||||||||||:|||||||.||||||||||...|.|||.|||||||||||| |:..:|||||.|||
  Rat   449 SADRQTRLEGAEINKSLLALKECIRALGRNKPHTPFRASKLTQVLRDSFI-GENSRTCMIATISP 512

  Fly   501 CLHSVEHTLNTLRYADRVKELSVESIPSKRMPDANLGSTSMSD 543
            .:.|.|:||||||||:|.:  |...|.:.:..:|..|..:..|
  Rat   513 GMASCENTLNTLRYANRYE--SDSYILNLKSREARHGVVAFDD 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp59C	NP_611759.1	KISc_KIF2_like	187..519	CDD:276818	219/331 (66%)
Klp59C	NP_611759.1	Kinesin	193..520	CDD:278646	215/326 (66%)
RGD1559908	XP_038952347.1	KISc_KIF2_like	203..529	CDD:276818	218/329 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D202066at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010