DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klp59C and kif24

DIOPT Version :9

Sequence 1:	NP_611759.1	Gene:	Klp59C / 37671	FlyBaseID:	FBgn0034824	Length:	626	Species:	Drosophila melanogaster
Sequence 2:	XP_031750808.1	Gene:	kif24 / 101731767	XenbaseID:	XB-GENE-855671	Length:	1371	Species:	Xenopus tropicalis

Alignment Length:	564	Identity:	217/564 - (38%)
Similarity:	302/564 - (53%)	Gaps:	88/564 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 SGGNAASANQTAS-ISPRSMKQRIATGSLSPVLATAP-------PRQQTAPPVREDE--VVHQAE 123
            |..|...:..||| ..||..:...::|:.:....:|.       |.:.:||.:.:.|  ::|:..
Frog   155 SMNNPGDSVSTASPADPRYCRNIHSSGTEADTTCSAKTQNTKTLPHRGSAPDLSDGEIPIIHRVA 219

  Fly   124 RMRKERERRREAQARTRLDREQGKNEDPGNPNWEVARMIRLQREQMESQRVRSGTTNERINCHQI 188
            .:.  .......|...|||..:.|                  |...|:.|:|
Frog   220 HVL--GYNYGVPQTCRRLDPTEKK------------------RPWTETDRIR------------- 251

  Fly   189 MVCVRKRPLRRKELADREQDVVSIPSKHTLVVHEPRKHVNLVKFLENHSFRFDYVFDEECSNATV 253
             ||||||||..:|....|.:|||...|.|:.::|.::.|||.:::..|:|.||.||.|..:|..|
Frog   252 -VCVRKRPLSSREERRGEVNVVSAEEKGTITIYERKEAVNLKEYILQHAFYFDEVFSETFTNQDV 315

  Fly   254 YEFTARPLIKHIFDGGMATCFAYGQTGSGKTYTMGGQFPGRHQSSMDGIYAMAAKDVFSTLKTVP 318
            |..||.|||:|:|:||.||||||||||:|||:||.|      .....|:||:||||:|..|.||.
Frog   316 YMRTAYPLIQHVFNGGNATCFAYGQTGAGKTHTMIG------TQKNPGLYALAAKDIFQQLATVQ 374

  Fly   319 YNKLNLKVYCSFFEIYGTRVFDLLMPGKPQLRVLEDRNQQVQVVGLTQNPVQNTAEVLDLLELGN 383
            . |.:.||:.||:|||..:::|||...| :|...||....||:.||.:..|.:...:|:::..|:
Frog   375 L-KSDCKVWISFYEIYCGQLYDLLNERK-RLYAREDGKHVVQIAGLREVQVSSVELLLEMILKGS 437

  Fly   384 SVRTSGHTSANSKSSRSHAVFQIVLRSAAGEKLHGKFSLIDLAGNERGADNSSADRQTRLEGSEI 448
            ..|::|.:..||.|||||||.||.::::...|| |:.|.|||||:||.:|...:|:||:|||:||
Frog   438 RERSTGASGVNSDSSRSHAVIQIQMKNSKNRKL-GRISFIDLAGSERASDAKESDKQTKLEGAEI 501

  Fly   449 NKSLLVLKECIRALGRQSSHLPFRGSKLTQVLRDSFIGGKKVKTCMIAMISPCLHSVEHTLNTLR 513
            |:|||.||||||||.::.:|.|||.|||||||:|||||..  ||||||.:||...:.||||||||
Frog   502 NQSLLALKECIRALDQEQAHTPFRQSKLTQVLKDSFIGNS--KTCMIANVSPSHIATEHTLNTLR 564

  Fly   514 YADRVKELSVESIPSKRMPDANLGSTSMSDIVCQSSTQRLFPCAS----STSMPGGGNQ------ 568
            ||||||||       ||      |:||      .|:..|...|.|    ..:..|.|::
Frog   565 YADRVKEL-------KR------GTTS------HSAHGRPAACVSPKRVQNAPAGSGDKISPKKV 610

  Fly   569 --AQQHTNTANDLNRSQKPT-SKPT-YPTSGQQLVQRKGSSQRE 608
              .|||.:.::.......|: ..|| .|.|.......|.|:.:|
Frog   611 KLGQQHISASHQAKSKSCPSVFHPTIIPLSSTPKYCSKSSTVKE 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp59C	NP_611759.1	KISc_KIF2_like	187..519	CDD:276818	168/331 (51%)
Klp59C	NP_611759.1	Kinesin	193..520	CDD:278646	166/326 (51%)
kif24	XP_031750808.1	SAM_KIF24-like	41..99	CDD:188940
kif24	XP_031750808.1	KISc_KIF2_like	249..570	CDD:276818	170/345 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D202066at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010