DRSC/TRiP Functional Genomics Resources

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Protein Alignment CycB and CLN3

DIOPT Version :10

Sequence 1:NP_726244.1 Gene:CycB / 37618 FlyBaseID:FBgn0000405 Length:530 Species:Drosophila melanogaster
Sequence 2:NP_009360.1 Gene:CLN3 / 851191 SGDID:S000000038 Length:580 Species:Saccharomyces cerevisiae


Alignment Length:421 Identity:92/421 - (21%)
Similarity:159/421 - (37%) Gaps:121/421 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   198 KDSLEVKKDATRMPLIRGNS---AVTTTTSTMPTTMSLSSKRLAGIEDIDANDKE-NLV------ 252
            ||:: ::....|.....|.|   |.:.:.::.|....|..||.|   ...|..|. |||      
Yeast     5 KDTI-IRYANARYATASGTSTATAASVSAASCPNLPLLLQKRRA---IASAKSKNPNLVKRELQA 65

  Fly   253 ---LVSEYVNDIYDYLYQV-ELEQPIHK-DHLAGQKEVSHKMRAVLIDWINEVHLQFHLAAETFQ 312
               .:|||.||..|:.::: ..|:|::. .:...|.:|:.|||.::.|:|...|.:.:|:..|..
Yeast    66 HHSAISEYNNDQLDHYFRLSHTERPLYNLTNFNSQPQVNPKMRFLIFDFIMYCHTRLNLSTSTLF 130

  Fly   313 LAVAIIDRYLQ--VVKDTKRTYLQLVGVTALFIATKY--EELFPPAIGDFVFITDDTYTARQIRQ 373
            |...|:|:|..  ::|...   .||:.:|||:|::|:  .:.....:.....:..:.|:.:|...
Yeast   131 LTFTILDKYSSRFIIKSYN---YQLLSLTALWISSKFWDSKNRMATLKVLQNLCCNQYSIKQFTT 192

  Fly   374 MELQIFKAID---CN------------------------LSRPLPIHF---LRRYSKAAGAEDEH 408
            ||:.:||::|   |.                        ||.||....   |...:.|||.....
Yeast   193 MEMHLFKSLDWSICQSATFDSYIDIFLFQSTSPLSPGVVLSAPLEAFIQQKLALLNNAAGTAINK 257

  Fly   409 HTMSK--------------YFIELASVDYEMA-TYRPSEIAAASLFLSLHLLNGNHRAGTGFNDR 458
            .:.|:              ...||||.:.|:: .|..|.||..:  ::|..|:.|:     :|..
Yeast   258 SSSSQGPSLNINEIKLGAIMLCELASFNLELSFKYDRSLIALGA--INLIKLSLNY-----YNSN 315

  Fly   459 HW---------------------TPTL--------TFYSRYSAAHLRPITRLIAKLARDAPQ--- 491
            .|                     :.||        :|.|.:.:.:|......:||...||.|   
Yeast   316 LWENINLALEENCQDLDIKLSEISNTLLDIAMDQNSFPSSFKSKYLNSNKTSLAKSLLDALQNYC 380

  Fly   492 -----------AKLKAIYNKYQGSKFQKIAL 511
                       .:|:.:||......|...:|
Yeast   381 IQLKLEEFYRSQELETMYNTIFAQSFDSDSL 411

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CycBNP_726244.1 CYCLIN_CCNB1-like_rpt1 254..384 CDD:410211 37/138 (27%)
CYCLIN_CCNB1-like_rpt2 389..509 CDD:410213 35/180 (19%)
CLN3NP_009360.1 COG5024 35..576 CDD:227357 86/390 (22%)

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