DRSC/TRiP Functional Genomics Resources

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Protein Alignment CycB and ccnf

DIOPT Version :10

Sequence 1:NP_726244.1 Gene:CycB / 37618 FlyBaseID:FBgn0000405 Length:530 Species:Drosophila melanogaster
Sequence 2:NP_996931.1 Gene:ccnf / 266981 ZFINID:ZDB-GENE-021030-2 Length:764 Species:Danio rerio


Alignment Length:488 Identity:98/488 - (20%)
Similarity:191/488 - (39%) Gaps:109/488 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   115 SVRNRVPTKTTV---------EPTKVTVKSSSSENVNEPTLKRED------SNLSKKSLT---KL 161
            |.::|.|...||         ...:..||...:...||..|..|:      ..::.:.|:   .|
Zfish    76 SFKDRWPAPDTVWLFERAAEKGNFEAAVKLGIAYLYNEGPLLSEEGRADLCGRMASRYLSLSESL 140

  Fly   162 RAALAKPVM--------GVSGIRREPVAVSRKEAETKKELP-------------------ETKKD 199
            |:..|:|.:        .|||...:.|...|.:||.:.. |                   |.|:|
Zfish   141 RSPQAEPFIWLFIRPPWSVSGSCCKAVVFDRLQAECQTS-PGRKGTLLYCLARVLQLFDDEEKRD 204

  Fly   200 SLEVK-KDATRMPLIRGNS---AVTTTTST---------MPTTMSLSSK-----RLAGIEDI-DA 245
            ..|:. |:::|...::.:.   |::..:||         |.|....:::     :||.::.. .|
Zfish   205 EAELMLKESSRCGSLQSSYLLWAISRASSTADPGRYLQCMRTLRDYAARGCWEAQLAFVKSCGSA 269

  Fly   246 NDKENLVLVSEYVNDIYDYLYQVELEQPIHKDHLAGQKEVSHKMRAVLIDWINEVHLQFHLAAET 310
            |.   |.|.....:::....:|.......::.||.|| :::.| |.:|:||:.||......:::.
Zfish   270 NP---LGLEPRACSELVSQFFQTGPSALRYQPHLQGQ-DITTK-RYILVDWLVEVTTTKDFSSQV 329

  Fly   311 FQLAVAIIDRYLQVVKDTKRTYLQLVGVTALFIATKY--EELFPPAIGDFVFITDDTYTARQIRQ 373
            ..:.::.:||||. ::...:..|||:|:..:.|.|::  :|:.  .|.:.|::||:||....:..
Zfish   330 LHVTISCVDRYLH-LRSVPKAQLQLLGIACMVICTRFISKEIL--TIREAVWLTDNTYQYEDLVH 391

  Fly   374 MELQIFKAIDCNLSRPLPIHFLRRYSKAAGAEDEHHTMSKYFIELASVDYEMATYRPSEIAAASL 438
            |..::...:|..:..|..:.:..........|.....:..|..||:.:........|:.:|:|.|
Zfish   392 MMGEVISVLDGKIRTPTVLDYGEVLLSLLPVERRTAHLFSYICELSLLCSPATVPGPARLASAIL 456

  Fly   439 FLSLHLLN------GNHRAGTGFNDRHWTP-TLTFYSRYSAAHLRPITRLIAKLARDAPQ----A 492
            .|:..|.|      ......|||:.:.... .||.|              |....:|.|:    .
Zfish   457 LLTRALHNYVPVWPVQLEENTGFSKQDLVSCALTLY--------------IKCFGQDVPKDYRHV 507

  Fly   493 KLKAIYNKYQGSKFQKIALRTELTGALMDSIVG 525
            .|..:..:::...:|:|:         .|:::|
Zfish   508 SLTGVKQRFEDDSYQQIS---------KDTVMG 531

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CycBNP_726244.1 CYCLIN_CCNB1-like_rpt1 254..384 CDD:410211 30/131 (23%)
CYCLIN_CCNB1-like_rpt2 389..509 CDD:410213 23/130 (18%)
ccnfNP_996931.1 Nuclear localization signal 1. /evidence=ECO:0000250|UniProtKB:P41002 19..27
F-box_FBXO1 40..81 CDD:438854 1/4 (25%)
CYCLIN_CCNF_rpt1 306..400 CDD:410225 25/97 (26%)
D box 1. /evidence=ECO:0000250|UniProtKB:P41002 309..312 1/2 (50%)
CYCLIN_CCNF_rpt2 428..539 CDD:410226 24/127 (19%)
Nuclear localization signal 2. /evidence=ECO:0000250|UniProtKB:P41002 570..575
PEST 583..738
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 662..754
Blue background indicates that the domain is not in the aligned region.

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