DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42260 and Cnga2

DIOPT Version :9

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_031750.2	Gene:	Cnga2 / 12789	MGIID:	108040	Length:	664	Species:	Mus musculus

Alignment Length:	483	Identity:	229/483 - (47%)
Similarity:	311/483 - (64%)	Gaps:	26/483 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   529 HGGAGSGGGSGPGSHGGQPHHQKPRRTASQRIRAATAARKLHFVFDPAGRLCYYWSMVVSMAFLY 593
            |.|.|.|...|.|.                    .|..:...||.||||...|.|..|::|..||
Mouse   111 HQGDGKGDKDGEGK--------------------GTKKKFELFVLDPAGDWYYRWLFVIAMPVLY 155

  Fly   594 NFWVIIYRFAFQEINRRTIAIWFCLDYLSDFLYLIDILFHFRTGYLEDGVLQTDALKLRTHYMNS 658
            |:.:::.|..|.::.|....:|..|||.||.:|:.|::...|||:||.|:|..|..|||.:|:::
Mouse   156 NWCLLVARACFSDLQRNYFVVWLVLDYFSDTVYIADLIIRLRTGFLEQGLLVKDPKKLRDNYIHT 220

  Fly   659 TIFYIDCLCLLPLDFLYLSIGFNS-ILRSFRLVKIYRFWAFMDRTERHTNYPNLFRSTALIHYLL 722
            ..|.:|...::|.|.:|.::|.:| .:|..||:...|.:.|.||||..|:|||:||.:.|:.|:|
Mouse   221 LQFKLDVASIIPTDLIYFAVGIHSPEVRFNRLLHFARMFEFFDRTETRTSYPNIFRISNLVLYIL 285

  Fly   723 VIFHWNGCLYHIIHKNNGFGSRNWVY---HDSESADVVKQYLQSYYWCTLALTTIGDLPKPRSKG 784
            ||.|||.|:|:.|.|:.|||...|||   .|.|...:.::|:...||.||.|||||:.|.|....
Mouse   286 VIIHWNACIYYAISKSIGFGVDTWVYPNITDPEYGYLAREYIYCLYWSTLTLTTIGETPPPVKDE 350

  Fly   785 EYVFVILQLLFGLMLFATVLGHVANIVTSVSAARKEFQAKLDGVKTYMRMRRVPNHLQVKVIKWF 849
            ||:|||...|.|:::|||::|:|.:::::::|.|.|||||:|.||.||:.|:|...::.||||||
Mouse   351 EYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKDMEAKVIKWF 415

  Fly   850 DYLWLTQKCSDEERAVSCLPDKLKAEIAINVHLDTLKRVEIFQNTEAGFLCELVLRLRPVLFSPG 914
            ||||..:|..||...:..||.||:|||||||||.|||:|.|||:.|||.|.||||:|||.:||||
Mouse   416 DYLWTNKKTVDEREVLKNLPAKLRAEIAINVHLSTLKKVRIFQDCEAGLLVELVLKLRPQVFSPG 480

  Fly   915 DYICRKGEVGKEMYIVNRGRLQVVADNGKTVMASLKAGSYFGEISILNM--GTAGNRRTASVRSV 977
            |||||||::||||||:..|:|.||||:|.|..|.|.|||.||||||||:  ...||||||::||:
Mouse   481 DYICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSL 545

  Fly   978 GYSDLFVLSKKDMWDVLKEYPAARVRLE 1005
            ||||||.|||.|:.:.:.|||.|:..||
Mouse   546 GYSDLFCLSKDDLMEAVTEYPDAKKVLE 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	97/241 (40%)
		CAP_ED	890..1004	CDD:237999	74/115 (64%)
		DUF4655	1084..>1154	CDD:317882
Cnga2	NP_031750.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..61
		Ion_trans	142..384	CDD:395416	97/241 (40%)
		Radical_SAM	417..>470	CDD:418514	32/52 (62%)
		CAP_ED	456..572	CDD:237999	74/115 (64%)
		CLZ	572..639	CDD:406832	2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	125	1.000	Domainoid score	I5442
eggNOG	1	0.900	-	-		E1_KOG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3407
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	1	1.000	-	-		FOG0000167
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100817
Panther	1	1.100	-	-	O	PTHR45638
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.770