Protein Alignment Ppa and gadr-4

DIOPT Version :10

• Sequence 1: NP_001261138.1
• Gene: Ppa / 37602
• FlyBaseID: FBgn0020257
• Length: 562
• Species: Drosophila melanogaster
• Sequence 2: NP_001317764.1
• Gene: gadr-4 / 173745
• WormBaseID: WBGene00021053
• Length: 797
• Species: Caenorhabditis elegans
• Alignment Length: 434
• Identity: 91/434 - (20%)
• Similarity: 164/434 - (37%)
• Gaps: 115/434 - (26%)

  Fly   152 LFPELLEQIFEHLPVRD--LGRAAQVCTAWRDAAYAKSVWKGVEAKLHLKRSSPSLFNCLVKRGI 214
            |:..:|: |.:.:|::.  ||:...:...::..:...|:...:..|..|..:|.:|...|   .|
 Worm   158 LYRGILD-ILKAMPIQSIKLGKLDLIENDYKQRSDKSSIDISMLIKSALSDNSRALLQHL---DI 218

  Fly   215 KKVQILSLRRSLKDLVLGVPALTSLNLSG-CFNVADMNLGHAFSVDLPNLKTLDLSLCKQITDTS 278
            :..::||:....| :.|.:|:|.||::.| .|.|.:..                 .||:...
 Worm   219 EGREVLSINWPRK-IGLLLPSLASLHVKGRSFFVFEFT-----------------QLCRSFP--- 262

  Fly   279 LGRIAQHLRNLETLELGGCCNITNTGLLLIAWGLKKLKHLNLRSCWHISDQGIGHLAGFSRETAE 343
                     ||.:|.:.| .||.|..      |:..||.|.:.|...:..:...||....
 Worm   263 ---------NLISLNISG-TNIKNLN------GISALKRLEVLSMQFLEIETTEHLINLF----- 306

  Fly   344 GNL-QLEYLGLQDCQRLSDEALGHI----AQGLTSLKSINLSFCVSVTDSGLKHLARMPKLEQLN 403
             || .|::|.:.|........:.|:    .:||.:||.::.:......|...|.|...||||.::
 Worm   307 -NLSNLKFLDISDIPEYDSCIIVHLYVECGKGLPNLKFMDCTATDINNDLLEKILISHPKLETIS 370

  Fly   404 --LRSCDNISDIGMAYLTEGG--SGINSLDVSFCDKISDQALTHIAQG-LYRLRSL--------- 454
              :.:...:||.|:..|....  |.:.||  ..|.:::   |.::|:. .|.:|.|
 Worm   371 AIVTNLHRVSDSGVCVLQTDAIDSAVTSL--IQCSRLN---LHYLAEKCFYEIRDLLESGQHFNA 430

  Fly   455 -----------SLNQCQI-TDHG---MLKIAKALHELENLNIGQCSRITDKGLQTLAEDLTNLKT 504
                       ..:.|.| ..||   ::::|:  |:.:.|.:.:.|.:.|    ||...:..|..
 Worm   431 SEFLRKIINLIETSSCPIRKKHGISYLIELAE--HQCQKLTLLEVSILLD----TLLNQVLELPE 489

  Fly   505 IDLYGCTQLSSKGIDIIMKLPKLQKLNLGLW-----LVRXCVHH 543
            ||.|               |.:.:..|:.:|     |.. ..||
 Worm   490 IDDY---------------LSENKSYNISMWCALDNLTNSENHH 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box_FBXL14	150..190	CDD:438897	7/39 (18%)
		AMN1	<226..>334	CDD:187754	23/108 (21%)
		leucine-rich repeat	236..256	CDD:275381	6/20 (30%)
		leucine-rich repeat	263..288	CDD:275381	2/24 (8%)
		leucine-rich repeat	289..314	CDD:275381	7/24 (29%)
		leucine-rich repeat	315..347	CDD:275381	8/32 (25%)
		AMN1	347..524	CDD:187754	43/209 (21%)
		leucine-rich repeat	348..373	CDD:275381	6/28 (21%)
		leucine-rich repeat	374..398	CDD:275381	5/23 (22%)
		leucine-rich repeat	399..424	CDD:275381	6/28 (21%)
		leucine-rich repeat	425..450	CDD:275381	5/25 (20%)
		leucine-rich repeat	451..475	CDD:275381	7/47 (15%)
		leucine-rich repeat	476..501	CDD:275381	5/24 (21%)
gadr-4	NP_001317764.1	LRR	161..>378	CDD:443914	56/263 (21%)