DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppa and AgaP_AGAP012769

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	XP_306070.4	Gene:	AgaP_AGAP012769 / 1267513	VectorBaseID:	AGAP012769	Length:	590	Species:	Anopheles gambiae

Alignment Length:	538	Identity:	108/538 - (20%)
Similarity:	173/538 - (32%)	Gaps:	229/538 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MATNTELLPFHHQTIAVLNNLNSHCGGSGSNGAATSGGAAIGGAGAGG-----APSWA------- 53
            :.|||  ...|||.::.:  |....||||..|    ||.  ||.|.||     .|..|
Mosquito   147 LLTNT--YQQHHQRLSPV--LRGPPGGSGGGG----GGG--GGGGGGGYHHPDEPQSALGGLSEA 201

  Fly    54 --------MDELYQQTEL--------PGLTRTGATTTHH-----HLL------------------ 79
                    ||.||.|..:        ..|||..::::::     |||
Mosquito   202 DRYFLEEKMDALYIQGAIRRNANATPSSLTRNQSSSSNNTERSPHLLRRASSPETSGSDRYLLDR 266

  Fly    80 -----------------------RFTP------YALHHRPPHHQLQTLPPALYLQHA--AAAAAA 113
                                   ||:|      :.|....|..|.|:..||.:....  .:....
Mosquito   267 IRGSPAIPLTKSQHYTDGLSRYGRFSPNLDQGYHTLVSPSPSGQQQSTIPASWTTGGTHGSGGGT 331

  Fly   114 AAAAAAHAQHHHHHHHHLPHRPASPESPPPVEG-------------------THISN-------- 151
            .:.:::|..            ||...:|....|                   |.:.|
Mosquito   332 NSTSSSHGS------------PAQTNTPVGGNGGNANGNGPCGRSIDGATILTSLGNGHGTSLYR 384

  Fly   152 ---LF----PELLEQIFEHLPVRDLGRAAQVCTAWRDAAYAKSVWKGVEAKLHLKRSSPSLFNCL 209
               ||    .||:.:|||.|...:|...|:||..:....:..::||.::.|
Mosquito   385 AGPLFDRMPDELMVRIFEWLDSSELCNIARVCRRFESVIWNPALWKIIKIK-------------- 435

  Fly   210 VKRGIKKVQILSLRRSLKDLVLGVPALTSLNLSGCFNVADMNLGHAFSVDLPNLKTLDLSLCKQI 274
                                                  .:.|.|..      .:||:...||.|
Mosquito   436 --------------------------------------GEENSGDR------AIKTILRRLCGQ- 455

  Fly   275 TDTSLGRIAQHLRN-----LETLELGGCCNITNTGLLLIAWGLKKLKHLNLRSCWHISDQGIGHL 334
                       .||     :|.:.|...|.:|:.||.|::....::.||.:::...|::|.:..|
Mosquito   456 -----------TRNGACPGVERVLLADGCRLTDRGLQLLSRRCPEITHLQIQNSVTITNQALSDL 509

  Fly   335 AGFSRETAEGNLQLEYLGLQDCQRLSDEALGHIAQGLTS-----LKSINLSFCVSVTDSGLKHLA 394
            .     |...|||  :|.:..|.:::   ..:|..||..     |:.::|:.|.|:.|:|:|.:|
Mosquito   510 V-----TKCTNLQ--HLDITGCAQIT---CININPGLEPPRRLLLQYLDLTDCASICDAGIKVIA 564

  Fly   395 R-MPKLEQLNLRSCDNIS 411
            | .|.|..|.||.|..::
Mosquito   565 RNCPLLVYLYLRRCIQVT 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	13/55 (24%)
		AMN1	<226..>334	CDD:187754	20/112 (18%)
		leucine-rich repeat	236..256	CDD:275381	2/19 (11%)
		leucine-rich repeat	263..288	CDD:275381	5/24 (21%)
		leucine-rich repeat	289..314	CDD:275381	7/24 (29%)
		leucine-rich repeat	315..347	CDD:275381	7/31 (23%)
		AMN1	347..524	CDD:187754	21/71 (30%)
		leucine-rich repeat	348..373	CDD:275381	5/24 (21%)
		leucine-rich repeat	374..398	CDD:275381	9/24 (38%)
		leucine-rich repeat	399..424	CDD:275381	5/13 (38%)
		leucine-rich repeat	425..450	CDD:275381
		leucine-rich repeat	451..475	CDD:275381
		leucine-rich repeat	476..501	CDD:275381
AgaP_AGAP012769	XP_306070.4	F-box-like	389..430	CDD:289689	11/40 (28%)
		leucine-rich repeat	402..428	CDD:275381	6/25 (24%)
		leucine-rich repeat	429..463	CDD:275381	12/103 (12%)
		leucine-rich repeat	464..489	CDD:275381	7/24 (29%)
		AMN1	474..>577	CDD:187754	31/112 (28%)
		leucine-rich repeat	490..515	CDD:275381	6/29 (21%)
		leucine-rich repeat	516..541	CDD:275381	7/29 (24%)
		leucine-rich repeat	544..569	CDD:275381	9/24 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810