DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdk9 and Cdk12

DIOPT Version :9

Sequence 1:	NP_477226.2	Gene:	Cdk9 / 37586	FlyBaseID:	FBgn0019949	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_001103096.1	Gene:	Cdk12 / 69131	MGIID:	1098802	Length:	1484	Species:	Mus musculus

Alignment Length:	334	Identity:	153/334 - (45%)
Similarity:	213/334 - (63%)	Gaps:	15/334 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 NKYEKVAKIGQGTFGEVFKAREKKGNKKFVAMKKVLMDNEKEGFPITALREIRILQLLKHENVVN 112
            :|::.:..||:||:|:|:||:: |...:.||:|||.:|||||||||||:|||:||:.|.|::|||
Mouse   721 DKFDIIGIIGEGTYGQVYKAKD-KDTGELVALKKVRLDNEKEGFPITAIREIKILRQLVHQSVVN 784

  Fly   113 LIEICRTKATATN--GYRSTFYLVFDFCEHDLAGLLSNMNVKFSLGEIKKVMQQLLNGLYYIHSN 175
            :.||...|..|.:  ..:..|||||::.:|||.|||.:..|.||...||..|:||:.||.|.|..
Mouse   785 MKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLDYCHKK 849

  Fly   176 KILHRDMKAANVLITKHGILKLADFGLARAFSIPKNESKNRYTNRVVTLWYRPPELLLGDRNYGP 240
            ..||||:|.:|:|:...|.:|||||||||.::   :|....|||:|:||||||||||||:..|.|
Mouse   850 NFLHRDIKCSNILLNNSGQIKLADFGLARLYN---SEESRPYTNKVITLWYRPPELLLGEERYTP 911

  Fly   241 PVDMWGAGCIMAEMWTRSPIMQGNTEQQQLTFISQLCGSFTPDVWPGVEELELYKSIELPKNQKR 305
            .:|:|..|||:.|::|:.||.|.|.|..||..||:||||..|.|||.|.:|..:.:::..|..:|
Mouse   912 AIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRR 976

  Fly   306 RVKERLRPYVKDQTGCDLLDKLLTLDPKKRIDADTALNHDFFWTDPMPSDLSKMLS---QHLQSM 367
            |::|.. .:: .....||||.:|||||.||..|:..|..||.    ...:||||..   .|.|..
Mouse   977 RLREEF-SFI-PSAALDLLDHMLTLDPSKRCTAEQTLQSDFL----KDVELSKMAPPDLPHWQDC 1035

  Fly   368 FEYLAQPRR 376
            .|..::.||
Mouse  1036 HELWSKKRR 1044

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdk9	NP_477226.2	STKc_CDK9	37..347	CDD:270848	143/300 (48%)
Cdk12	NP_001103096.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..465
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	483..699
		STKc_CDK12	715..1016	CDD:270847	143/300 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1044..1101		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1156..1199
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1219..1363
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1437..1484
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925637at2759
OrthoFinder	1	1.000	-	-		FOG0000444
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R186
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.950