Protein Alignment Cdk9 and Cdk12

DIOPT Version :8

• Sequence 1: NP_477226.2
• Gene: Cdk9 / 37586
• FlyBaseID: FBgn0019949
• Length: 404
• Species: Drosophila melanogaster
• Sequence 2: NP_001262167.1
• Gene: Cdk12 / 40385
• FlyBaseID: FBgn0037093
• Length: 1157
• Species: Drosophila melanogaster
• Alignment Length: 351
• Identity: 153/352 (43%)
• Similarity: 218/352 (62%)
• Gaps: 31/352 (9%)

  Fly    50 YEKVAKIGQGTFGEVFKAREKKGNKKFVAMKKVLMDNEKEGFPITALREIRILQLLKHENVVNLI 114
            :|.:|:||:||:|:|:|||:...| ..||:|||.:::|||||||||:|||:||:.|.|.|:|||.
  Fly   804 FEMIAQIGEGTYGQVYKARDHHTN-DMVALKKVRLEHEKEGFPITAVREIKILRQLNHRNIVNLH 867

  Fly   115 EICRTKATATNGYR---STFYLVFDFCEHDLAGLLSNMNVKFSLGEIKKVMQQLLNGLYYIHSNK 176
            ||...|..|.. :|   .:|||||::.:|||.|||.:..|.|:......:|:|||:||.|.|...
  Fly   868 EIVTDKQDAVE-FRKDKGSFYLVFEYMDHDLMGLLESGMVDFNEENNASIMKQLLDGLNYCHKKN 931

  Fly   177 ILHRDMKAANVLITKHGILKLADFGLARAFSIPKNESKNRYTNRVVTLWYRPPELLLGDRNYGPP 241
            .||||:|.:|:|:...|.:|||||||||.::  .::.:..|||:|:||||||||||||:..|||.
  Fly   932 FLHRDIKCSNILMNNRGKVKLADFGLARLYN--ADDRERPYTNKVITLWYRPPELLLGEERYGPS 994

  Fly   242 VDMWGAGCIMAEMWTRSPIMQGNTEQQQLTFISQLCGSFTPDVWPGVEELELYKSIELPKNQKRR 306
            :|:|..|||:.|::.:.|:.|.|.|..||..||::|||..|.|||.|.:|.|:.:::..|..:||
  Fly   995 IDVWSCGCILGELFVKRPLFQANAEMAQLETISKICGSPVPAVWPNVIKLPLFHTLKQKKTHRRR 1059

  Fly   307 VKERLRPYVKDQTGCDLLDKLLTLDPKKRIDADTAL--------NHDFFWTDPMPS--DLSKMLS 361
            ::|...  .......|||||:|.|||.|||.|:.||        |.|...|..:|:  |..::.|
  Fly  1060 LREDFE--FMPAPALDLLDKMLDLDPDKRITAEDALRSPWLRKINPDEMPTPQLPTWQDCHELWS 1122

  Fly   362 QHLQSMFEYLAQPRRSNQMRNYHQQL 387
            :            :|..|||...:.|
  Fly  1123 K------------KRRRQMREQQESL 1136

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk9	NP_477226.2	STKc_CDK9	37..347	CDD:270848	144/308 (47%)
		S_TKc	50..347	CDD:214567	144/308 (47%)
Cdk12	NP_001262167.1	STKc_CDK12	796..1098	CDD:270847	142/300 (47%)
		S_TKc	804..1098	CDD:214567	142/300 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C111426323
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OrthoDB	1	1.010				D344403at33208
OrthoFinder	1	1.000				FOG0000559
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100			P	PTHR24056
RoundUp	1	1.030		avgDist	Average_Evolutionary_Distance	R186
	5	5.070