Protein Alignment Cdk9 and cdk8

DIOPT Version :10

• Sequence 1: NP_477226.2
• Gene: Cdk9 / 37586
• FlyBaseID: FBgn0019949
• Length: 404
• Species: Drosophila melanogaster
• Sequence 2: NP_989246.1
• Gene: cdk8 / 394856
• XenbaseID: XB-GENE-962267
• Length: 464
• Species: Xenopus tropicalis
• Alignment Length: 407
• Identity: 131/407 - (32%)
• Similarity: 201/407 - (49%)
• Gaps: 60/407 - (14%)

  Fly    38 DYDF--PYCDESNKYEKV-----AKIGQGTFGEVFKAREKKG-NKKFVAMKKVLMDNEKEGFPIT 94
            ||||  ....|..:.|.:     .|:|:||:|.|:||:.|.| :.:..|:|::    |..|..::
 Frog     2 DYDFKVKLTGERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGRDDRDYALKQI----EGTGISMS 62

  Fly    95 ALREIRILQLLKHENVVNLIEICRTKATATNGYRSTFYLVFDFCEHDL--------AGLLSNMNV 151
            |.|||.:|:.|||.||::|.::..:.|.      ...:|:|||.||||        |...:...|
 Frog    63 ACREIALLRELKHPNVISLQKVFLSHAD------RKVWLLFDFAEHDLWHIIKFHRASKANKKPV 121

  Fly   152 KFSLGEIKKVMQQLLNGLYYIHSNKILHRDMKAANVLI----TKHGILKLADFGLARAFSIPKNE 212
            :...|.:|.::.|:|:|::|:|:|.:||||:|.||:|:    .:.|.:|:||.|.||.|:.|...
 Frog   122 QLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKP 186

  Fly   213 SKNRYTNRVVTLWYRPPELLLGDRNYGPPVDMWGAGCIMAEMWTRSPIMQGNTE---------QQ 268
            ..: ....|||.|||.||||||.|:|...:|:|..|||.||:.|..||.....|         ..
 Frog   187 LAD-LDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHD 250

  Fly   269 QLTFISQLCGSFTPDVWPGVEELELYKSI--ELPKNQ-------KRRVKERLRPYVKDQTGCDLL 324
            ||..|..:.|......|..::::..:.::  :..:|.       |...|.:::|   |.....||
 Frog   251 QLDRIFNVMGFPADKDWEDIKKMPEHSTLIKDFRRNTYTNCSLIKYMEKHKVKP---DSKTFHLL 312

  Fly   325 DKLLTLDPKKRIDADTALNHDFFWTDPMPSDLSKMLSQHLQSMFEYLA--QPRRSNQMRNYHQQL 387
            .||||:||.|||.::.|:...:|..||:|:.......|......|:|.  :|......:|..||.
 Frog   313 QKLLTMDPIKRISSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLTEEEPDDKGDKKNQQQQQ 377

  Fly   388 ----TTMNQKP--QDNS 398
                |.....|  ||||
 Frog   378 GNNHTNGTGHPGNQDNS 394

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk9	NP_477226.2	STKc_CDK9	37..347	CDD:270848	114/346 (33%)
cdk8	NP_989246.1	Interaction with CCNC. /evidence=ECO:0000250	1..15		5/12 (42%)
		Protein Kinases, catalytic domain	3..335	CDD:473864	113/345 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	361..464		10/34 (29%)