Protein Alignment Cdk9 and CDKL4

DIOPT Version :10

• Sequence 1: NP_477226.2
• Gene: Cdk9 / 37586
• FlyBaseID: FBgn0019949
• Length: 404
• Species: Drosophila melanogaster
• Sequence 2: NP_001333840.1
• Gene: CDKL4 / 344387
• HGNCID: 19287
• Length: 379
• Species: Homo sapiens
• Alignment Length: 361
• Identity: 123/361 - (34%)
• Similarity: 175/361 - (48%)
• Gaps: 64/361 - (17%)

  Fly    49 KYEKVAKIGQGTFGEVFKAREKKGNKKFVAMKKVLMDNEKEGFPIT---ALREIRILQLLKHENV 110
            ||||:||.|:|::|.|||.|.|... :.||:||.:   |.|..|:.   ||||||:|:.|||.|:
Human     3 KYEKLAKTGEGSYGVVFKCRNKTSG-QVVAVKKFV---ESEDDPVVKKIALREIRMLKQLKHPNL 63

  Fly   111 VNLIEICRTKATATNGYRSTFYLVFDFCEHDLAGLLSNMNVKFSLGEIKKVMQQLLNGLYYIHSN 175
            |||||:.|.|        ...:|||::|:|.|...|.......:.|.||.|:.|.|..|.:.|.:
Human    64 VNLIEVFRRK--------RKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHIH 120

  Fly   176 KILHRDMKAANVLITKHGILKLADFGLARAFSIPKNESKNRYTNRVVTLWYRPPELLLGDRNYGP 240
            ..:|||:|..|:||||.||:|:.|||.|:.. ||    .:.||:.|.|.|||.||||:||..||.
Human   121 NCIHRDIKPENILITKQGIIKICDFGFAQIL-IP----GDAYTDYVATRWYRAPELLVGDTQYGS 180

  Fly   241 PVDMWGAGCIMAEMWTRSPIMQGNTEQQQLTFISQLCGSFTPDVWPGVEELELYKS------IEL 299
            .||:|..||:.||:.|..|:..|.::..||..|.:..|...|      ....::||      |.:
Human   181 SVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIP------RHQSIFKSNGFFHGISI 239

  Fly   300 PKNQKRRVKER----LRPYVKD-QTGCDLLDKLLTLDPKKRIDADTALNHDFFWTDPMPSDLSKM 359
            |:.:.....|.    :.|...: ..||      |.::|..|:.....|...:|
Human   240 PEPEDMETLEEKFSDVHPVALNFMKGC------LKMNPDDRLTCSQLLESSYF------------ 286

  Fly   360 LSQHLQSMFEYLAQPRRSNQMRNYHQQLTTMNQKPQ 395
                 .|..|...:.:..|:.||..:|    .|.|:
Human   287 -----DSFQEAQIKRKARNEGRNRRRQ----QQAPK 313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk9	NP_477226.2	STKc_CDK9	37..347	CDD:270848	114/311 (37%)
CDKL4	NP_001333840.1	STKc_CDKL1_4	2..286	CDD:270837	114/311 (37%)
		[NKR]KIAxRE	45..51		2/5 (40%)