DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdk9 and lsk1

DIOPT Version :9

Sequence 1:	NP_477226.2	Gene:	Cdk9 / 37586	FlyBaseID:	FBgn0019949	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_594393.1	Gene:	lsk1 / 2541672	PomBaseID:	SPAC2F3.15	Length:	593	Species:	Schizosaccharomyces pombe

Alignment Length:	351	Identity:	141/351 - (40%)
Similarity:	210/351 - (59%)	Gaps:	31/351 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 IEDYDFPYCDESNKYEKVAKIGQGTFGEVFKA-REKKGNKKFVAMKKVLMDNEKEGFPITALREI 99
            |..|.:|    ...|||:.:||:||:|:|:|| ....|:  .||:|::.::.||:|||||.:||:
pombe   267 IYTYTYP----KPAYEKIDQIGEGTYGKVYKAINTVTGD--LVALKRIRLEQEKDGFPITTVREV 325

  Fly   100 RILQLLKHENVVNLIEICRTKATATNGYRSTFYLVFDFCEHDLAGLLSNMNVKFSLGEIKKVMQQ 164
            :|||.|:|:|:|.|:||...|        |:.|:||::.:|||.|:|.|..:.|:.|.||.:.:|
pombe   326 KILQRLRHKNIVRLLEIMVEK--------SSVYMVFEYMDHDLTGVLLNSQLHFTPGNIKHLSKQ 382

  Fly   165 LLNGLYYIHSNKILHRDMKAANVLITKHGILKLADFGLARAFSIPKNESKNRYTNRVVTLWYRPP 229
            :...|.|:|...:||||:|.:|:|:..:|.||.|||||||..:..|:.:   |||||:|||:|||
pombe   383 IFEALAYLHHRGVLHRDIKGSNILLNNNGDLKFADFGLARFNTSSKSAN---YTNRVITLWFRPP 444

  Fly   230 ELLLGDRNYGPPVDMWGAGCIMAEMWTRSPIMQGNTEQQQLTFISQLCGSFTPDV--WPGVEELE 292
            |||||:..|...||:|.||||:.|::|..|..||..|..||..|..:.|  ||||  ||.|:.|.
pombe   445 ELLLGETAYDTAVDIWSAGCIVMELFTGKPFFQGRDEISQLEVIYDMMG--TPDVHSWPEVKNLP 507

  Fly   293 LYKSIELPKNQKRR----VKERLRPYVKDQTGCDLLDKLLTLDPKKRIDADTALNHDFFWTDPMP 353
            .|:.::..:.:|.|    .||.|.|     ...||..|||.|:|..|..|...|.|::|.::..|
pombe   508 WYELLKPVEEKKSRFVETFKEILSP-----AAIDLCQKLLALNPFCRPSAHETLMHEYFTSESPP 567

  Fly   354 SDLSKMLSQHLQSMFEYLAQPRRSNQ 379
            .:.:.:|.....|..|:.::.|:|.:
pombe   568 PEPAVILKNMQGSWHEWESKKRKSKR 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdk9	NP_477226.2	STKc_CDK9	37..347	CDD:270848	133/316 (42%)
lsk1	NP_594393.1	STKc_CDK9_like	277..561	CDD:270832	131/303 (43%)
lsk1	NP_594393.1	S_TKc	277..561	CDD:214567	131/303 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24056
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R186
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.040