Protein Alignment Cdk9 and CDK8

DIOPT Version :10

• Sequence 1: NP_477226.2
• Gene: Cdk9 / 37586
• FlyBaseID: FBgn0019949
• Length: 404
• Species: Drosophila melanogaster
• Sequence 2: NP_001251.1
• Gene: CDK8 / 1024
• HGNCID: 1779
• Length: 464
• Species: Homo sapiens
• Alignment Length: 392
• Identity: 127/392 - (32%)
• Similarity: 197/392 - (50%)
• Gaps: 60/392 - (15%)

  Fly    38 DYDFPYCDESNKYEKV--------AKIGQGTFGEVFKAREKKG-NKKFVAMKKVLMDNEKEGFPI 93
            ||||. ...|::.|:|        .|:|:||:|.|:||:.|.| :.|..|:|::    |..|..:
Human     2 DYDFK-VKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGISM 61

  Fly    94 TALREIRILQLLKHENVVNLIEICRTKATATNGYRSTFYLVFDFCEHDL--------AGLLSNMN 150
            :|.|||.:|:.|||.||::|.::..:.|.      ...:|:||:.||||        |...:...
Human    62 SACREIALLRELKHPNVISLQKVFLSHAD------RKVWLLFDYAEHDLWHIIKFHRASKANKKP 120

  Fly   151 VKFSLGEIKKVMQQLLNGLYYIHSNKILHRDMKAANVLI----TKHGILKLADFGLARAFSIPKN 211
            |:...|.:|.::.|:|:|::|:|:|.:||||:|.||:|:    .:.|.:|:||.|.||.|:.|..
Human   121 VQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLK 185

  Fly   212 ESKNRYTNRVVTLWYRPPELLLGDRNYGPPVDMWGAGCIMAEMWTRSPIMQGNTE---------Q 267
            ...: ....|||.|||.||||||.|:|...:|:|..|||.||:.|..||.....|         .
Human   186 PLAD-LDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHH 249

  Fly   268 QQLTFISQLCGSFTPDVWPGVEELELYKSIELPKNQKRRV-----------KERLRPYVKDQTGC 321
            .||..|..:.|......|..::::..:.:  |.|:.:|..           |.:::|   |....
Human   250 DQLDRIFNVMGFPADKDWEDIKKMPEHST--LMKDFRRNTYTNCSLIKYMEKHKVKP---DSKAF 309

  Fly   322 DLLDKLLTLDPKKRIDADTALNHDFFWTDPMPSDLSKMLSQHLQSMFEYLA--QPRRSNQMRNYH 384
            .||.||||:||.|||.::.|:...:|..||:|:.......|......|:|.  :|......:|..
Human   310 HLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLTEEEPDDKGDKKNQQ 374

  Fly   385 QQ 386
            ||
Human   375 QQ 376

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk9	NP_477226.2	STKc_CDK9	37..347	CDD:270848	116/349 (33%)
CDK8	NP_001251.1	Interaction with CCNC	1..15		5/13 (38%)
		STKc_CDK8	3..335	CDD:270851	115/348 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	361..464		4/16 (25%)