Protein Alignment Cdk9 and CDK7

DIOPT Version :10

• Sequence 1: NP_477226.2
• Gene: Cdk9 / 37586
• FlyBaseID: FBgn0019949
• Length: 404
• Species: Drosophila melanogaster
• Sequence 2: NP_001790.1
• Gene: CDK7 / 1022
• HGNCID: 1778
• Length: 346
• Species: Homo sapiens
• Alignment Length: 319
• Identity: 124/319 - (38%)
• Similarity: 182/319 - (57%)
• Gaps: 36/319 - (11%)

  Fly    47 SNKYEKVAKIGQGTFGEVFKAREKKGNKKFVAMKKVLMDNE---KEGFPITALREIRILQLLKHE 108
            :.:|||:..:|:|.|..|:|||:|..| :.||:||:.:.:.   |:|...||||||::||.|.|.
Human     9 AKRYEKLDFLGEGQFATVYKARDKNTN-QIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHP 72

  Fly   109 NVVNLIEICRTKATATNGYRSTFYLVFDFCEHDLAGLLSNMNVKFSLGEIKKVMQQLLNGLYYIH 173
            |::.|::        ..|::|...|||||.|.||..::.:.::..:...||..|...|.||.|:|
Human    73 NIIGLLD--------AFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLH 129

  Fly   174 SNKILHRDMKAANVLITKHGILKLADFGLARAFSIPKNESKNR-YTNRVVTLWYRPPELLLGDRN 237
            .:.|||||:|..|:|:.::|:|||||||||::|..|     || ||::|||.|||.||||.|.|.
Human   130 QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSP-----NRAYTHQVVTRWYRAPELLFGARM 189

  Fly   238 YGPPVDMWGAGCIMAEMWTRSPIMQGNTEQQQLTFISQLCGSFTPDVWPGVEELELYKSIE---- 298
            ||..||||..|||:||:..|.|.:.|:::..|||.|.:..|:.|.:.||.:..|..|.:.:
Human   190 YGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPG 254

  Fly   299 LPKNQKRRVKERLRPYVKDQTGCDLLD---KLLTLDPKKRIDADTALNHDFFWTDPMPS 354
            :|.:           ::....|.||||   .|...:|..||.|..||...:|...|.|:
Human   255 IPLH-----------HIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPT 302

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk9	NP_477226.2	STKc_CDK9	37..347	CDD:270848	121/310 (39%)
CDK7	NP_001790.1	STKc_CDK7	11..308	CDD:270833	124/317 (39%)