Protein Alignment Cdk9 and CDK6

DIOPT Version :10

• Sequence 1: NP_477226.2
• Gene: Cdk9 / 37586
• FlyBaseID: FBgn0019949
• Length: 404
• Species: Drosophila melanogaster
• Sequence 2: NP_001250.1
• Gene: CDK6 / 1021
• HGNCID: 1777
• Length: 326
• Species: Homo sapiens
• Alignment Length: 332
• Identity: 127/332 - (38%)
• Similarity: 189/332 - (56%)
• Gaps: 35/332 - (10%)

  Fly    44 CDESNKYEKVAKIGQGTFGEVFKAREKKGNKKFVAMKKVLMDNEKEGFPITALREIRILQLL--- 105
            |....:||.||:||:|.:|:|||||:.|...:|||:|:|.:...:||.|::.:||:.:|:.|
Human     7 CRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71

  Fly   106 KHENVVNLIEICRTKATATNGYRST-FYLVFDFCEHDLAGLLSNM-NVKFSLGEIKKVMQQLLNG 168
            :|.|||.|.::|    |.:...|.| ..|||:..:.||...|..: ........||.:|.|||.|
Human    72 EHPNVVRLFDVC----TVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRG 132

  Fly   169 LYYIHSNKILHRDMKAANVLITKHGILKLADFGLARAFSIPKNESKNRYTNRVVTLWYRPPELLL 233
            |.::||::::|||:|..|:|:|..|.:|||||||||.:|.     :...|:.|||||||.||:||
Human   133 LDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSF-----QMALTSVVVTLWYRAPEVLL 192

  Fly   234 GDRNYGPPVDMWGAGCIMAEMWTRSPIMQGNTEQQQLTFISQLCGSFTPDVWPGVEELELYKSIE 298
             ..:|..|||:|..|||.|||:.|.|:.:|:::..||..|..:.|....:.||        :.:.
Human   193 -QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP--------RDVA 248

  Fly   299 LPKNQ-KRRVKERLRPYVK--DQTGCDLLDKLLTLDPKKRIDADTALNHDFFWTDPMPSDLSKM- 359
            ||:.. ..:..:.:..:|.  |:.|.|||.|.||.:|.|||.|.:||:|.:|      .||.:.
Human   249 LPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF------QDLERCK 307

  Fly   360 --LSQHL 364
              |..||
Human   308 ENLDSHL 314

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk9	NP_477226.2	STKc_CDK9	37..347	CDD:270848	121/310 (39%)
CDK6	NP_001250.1	STKc_CDK6	11..300	CDD:270846	120/306 (39%)