DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dnr1 and CG34347

DIOPT Version :9

Sequence 1:	NP_001261137.1	Gene:	dnr1 / 37575	FlyBaseID:	FBgn0260866	Length:	696	Species:	Drosophila melanogaster
Sequence 2:	NP_001368952.1	Gene:	CG34347 / 5740668	FlyBaseID:	FBgn0085376	Length:	1519	Species:	Drosophila melanogaster

Alignment Length:	547	Identity:	103/547 - (18%)
Similarity:	173/547 - (31%)	Gaps:	215/547 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VNLPNGTQQAVKWDPKANGQECLEKVCRAMNIICEMEYFGLEHWTPNQKESQTRQWINLRNRLSG 69
            :||.:.|:...:......||..|:.|...:|:| |..|||:.:   ..:|:|| .|::..:|:|.
  Fly    15 INLLDETEFIHEIKDDLPGQALLDVVFARLNLI-ETSYFGIRY---IDEENQT-HWLDPASRISR 74

  Fly    70 DSGSSGSGIQLMLALRVKFWV--PVHFILQESVRNLFYMQARRDLLEGRLTAPDWSGAAKLAALL 132
            ..........|...  |||:.  |.. :|:|..|...::|.::|:|:|||... :..||:|.|.:
  Fly    75 QLKPKSDPYDLYFG--VKFYAADPCK-LLEEITRYQLFLQVKQDVLQGRLPVA-FELAAELGAFV 135

  Fly   133 CQADGLRFNESSLKADCPMRMRRELAQQQQQQQQQAQQHRLEQQRKEKEHVLSFKKRRLSKQKSM 197
            .|:                    ||..             .:|:|..|.:|..|:
  Fly   136 VQS--------------------ELGD-------------YDQRRHSKGYVSEFR---------- 157

  Fly   198 EHIEVCTLPAASTTSCSLQPSPSASASASASASASASASTSACSQTHSNSSSSSPSNSSSQTGLD 262
                             |.|:.|             :...:..|:.|......|||::.
  Fly   158 -----------------LLPNQS-------------NELETRVSELHQQLKGMSPSSAE------ 186

  Fly   263 ERLASNPLRVYEEYFMQPSCEGEPPADYLRQIAVEHGKLAKLQMSLKTAKYWLLKSIQDLEG--- 324
                                     .:||.::.                  |     .|:.|
  Fly   187 -------------------------LNYLDKVK------------------W-----HDMYGVDL 203

  Fly   325 ---YGE---ELFSGVTTNESATRCDIAVGAHGITVCRGGEKQSIP---FGAIAAAKSLRRTFKLE 380
               .||   |.|.|:|.:             ||.|.|  .|.::.   :..||......|.|.|.
  Fly   204 HPVLGEDSVEYFLGLTPS-------------GIVVLR--NKTTVAHYYWPRIAKVYYKGRYFMLR 253

  Fly   381 YVDDHNDRKELEIKLPKQPIAAGLYRSITERHAFYVCDKVRGVVTNQFTRDLKGTIASMFMENTE 445
            ..|.:|:......:.|::.....|:|...|.|||:...:|..:.::|      ...|.:|    :
  Fly   254 ISDKNNELSTYGFETPRKSACKHLWRCCVEHHAFFRQVRVAPLPSSQ------SHAADLF----Q 308

  Fly   446 LGKRYVFDIQH---------------------TCREVHDQARRTLHE-------------RGGDL 476
            ||.|:    :|                     |......|.||.:.:             ..|:.
  Fly   309 LGSRF----RHSRPDKQTEKDALSAGRSPPAFTRTPSKRQPRRVIDDFFNSNGNGNGNGNGNGNG 369

  Fly   477 VAEGAEGCSAVAGG--LGASAVGEPGV 501
            ...|..|...:.||  :|...:.:||:
  Fly   370 HGHGGSGAGTLGGGSHMGNRPLPQPGM 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dnr1	NP_001261137.1	B41	3..>143	CDD:214604	38/139 (27%)
		FERM_N	5..67	CDD:286467	17/61 (28%)
		FERM_M	93..>143	CDD:278785	14/49 (29%)
		FERM_C_MYLIP_IDOL	325..435	CDD:270016	27/115 (23%)
		zf-C3HC4_3	544..589	CDD:290631
CG34347	NP_001368952.1	B41	13..204	CDD:214604	58/324 (18%)
		FERM_C_NBL4_NBL5	200..289	CDD:270007	26/103 (25%)
		FA	305..347	CDD:400882	7/49 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23280
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010