Protein Alignment dnr1 and XIAP

DIOPT Version :10

• Sequence 1: NP_001261137.1
• Gene: dnr1 / 37575
• FlyBaseID: FBgn0260866
• Length: 696
• Species: Drosophila melanogaster
• Sequence 2: NP_001158.2
• Gene: XIAP / 331
• HGNCID: 592
• Length: 497
• Species: Homo sapiens
• Alignment Length: 527
• Identity: 110/527 - (20%)
• Similarity: 177/527 - (33%)
• Gaps: 159/527 - (30%)

  Fly   178 KEKEHVLSFKKRRLSKQKSMEHIEVCTLPAASTTSCSLQPSPSASASASASASASASASTSACSQ 242
            ||:|.|..|.:.:          .....|:.|..        |||..|.|....:....|..|..
Human    19 KEEEFVEEFNRLK----------TFANFPSGSPV--------SASTLARAGFLYTGEGDTVRCFS 65

  Fly   243 THS------------------------------NSSSSSPSNSSSQTG---LDERLASNPLRVYE 274
            .|:                              .:|::..:||..|.|   ::..|.|      .
Human    66 CHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGS------R 124

  Fly   275 EYFM--QPSCEGEPPADYLRQIAVEHGKLAKLQMSL---KTAKY---WLLKSIQDLEGYGEELFS 331
            ::|.  :||   |..||||    :..|::..:..::   ..|.|   ..|||.|:...|..
Human   125 DHFALDRPS---ETHADYL----LRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAH---- 178

  Fly   332 GVTTNE--SATRCDIAVGAHGITVCRGGE--------------KQSIPFGAIAAAKSLRRTFKLE 380
             :|..|  ||......:|......|.||:              ::..|.......::|....:.:
Human   179 -LTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESD 242

  Fly   381 YVDDHNDRK-ELEIKLPKQPIAAG-----------LYRSITE---RHAFYVC---DKVR-----G 422
            .|.  :||. .....||:.|..|.           :|....|   |..||..   |||:     |
Human   243 AVS--SDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGG 305

  Fly   423 VVTN---------QFTRDLKGTIASMFMENTELGKRYVFDIQHTCREVHDQARRT------LHER 472
            .:|:         |..:...|  ....:|  :.|:.|:.:| |....:.:...||      |..|
Human   306 GLTDWKPSEDPWEQHAKWYPG--CKYLLE--QKGQEYINNI-HLTHSLEECLVRTTEKTPSLTRR 365

  Fly   473 GGDLVAEGAEGCSAVAGGLGASAVGEPGVSPWAMALTTGAGGSMAGKIDLAI----------REK 527
            ..|.:.:......|:..|.....:.:      .|.......||....:::.:          .:.
Human   366 IDDTIFQNPMVQEAIRMGFSFKDIKK------IMEEKIQISGSNYKSLEVLVADLVNAQKDSMQD 424

  Fly   528 EAREAAIERCVDT-----RISEAMQCKICMDRAINTVFNPCCHVIACAQCAARCSNCPNCRVKIT 587
            |:.:.::::.:.|     |:.|...|||||||.|..||.||.|::.|.|||.....||.|...||
Human   425 ESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVIT 489

  Fly   588 SVVKIYL 594
            ...||::
Human   490 FKQKIFM 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnr1	NP_001261137.1	Ubl1_cv_Nsp3_N-like	1..89	CDD:475130
		FERM_M	91..>148	CDD:459788
		FERM_C_MYLIP_IDOL	325..435	CDD:270016	29/157 (18%)
		RING-HC_IAPs	545..583	CDD:438173	19/37 (51%)
XIAP	NP_001158.2	BIR 1	26..93		11/84 (13%)
		BIR	28..95	CDD:237989	10/84 (12%)
		Interaction with caspase-7	141..149		1/7 (14%)
		BIR	162..232	CDD:197595	14/74 (19%)
		BIR 2	163..230		14/71 (20%)
		Required for interaction with SEPTIN4 isoform ARTS. /evidence=ECO:0000269|PubMed:21695558	262..277		1/14 (7%)
		BIR	265..331	CDD:197595	12/67 (18%)
		BIR 3	265..330		12/66 (18%)
		Required for interaction with DIABLO. /evidence=ECO:0000269|PubMed:21695558	329..350		5/23 (22%)
		UBA_BIRC4_8	370..419	CDD:270578	5/54 (9%)
		RING-HC_BIRC4_8	434..497	CDD:438374	27/63 (43%)
		Required for ubiquitination and subsequent degradation of BCL2 during apoptosis. /evidence=ECO:0000269|PubMed:29020630	450..497		24/47 (51%)