Protein Alignment rad50 and RAD50

DIOPT Version :10

• Sequence 1: NP_726199.3
• Gene: rad50 / 37564
• FlyBaseID: FBgn0034728
• Length: 1318
• Species: Drosophila melanogaster
• Sequence 2: NP_014149.1
• Gene: RAD50 / 855471
• SGDID: S000005194
• Length: 1312
• Species: Saccharomyces cerevisiae
• Alignment Length: 1402
• Identity: 390/1402 - (27%)
• Similarity: 713/1402 - (50%)
• Gaps: 191/1402 - (13%)

  Fly     1 MSSIESLSIQGIRSFGTYADDLQSIKFSSPVTLILGENGCGKTTVVECLKYALTGECPPGSDRGK 65
            ||:|..|||||||||.  ::|.::|:|..|:|||:|.||.||||::||||||.||:.||.| :|.
Yeast     1 MSAIYKLSIQGIRSFD--SNDRETIEFGKPLTLIVGMNGSGKTTIIECLKYATTGDLPPNS-KGG 62

  Fly    66 SFVHDPKIFGLNEVLAQIKMQVRDRRGAQVSICRTMKVSKKRNKMSFETMDSTINFLTGAGQSKR 130
            .|:|||||.|..::.||:|:......|..:.:.|.:::..|:...:|:|::..:..:..:|.
Yeast    63 VFIHDPKITGEKDIRAQVKLAFTSANGLNMIVTRNIQLLMKKTTTTFKTLEGQLVAINNSGD--- 124

  Fly   131 EKQDSLSGRSVDIDVAISDFMGVSKAIINNVLFCHQEDSSWPLDESKKLKEKFDAIFGITEYNKA 195
              :.:||.||:::|..:..::||.|||:..|:|||||||.|||.|...||:|||.||...::.||
Yeast   125 --RSTLSTRSLELDAQVPLYLGVPKAILEYVIFCHQEDSLWPLSEPSNLKKKFDEIFQAMKFTKA 187

  Fly   196 LDKIIKLRKEAMEELKIKEANIKHVAYLKQEMEVKTLNLQKAQRKCDAIKAQCSECEEEMKPIEA 260
            ||.:..::|:...::|:.:.:::|:...|...:...||:.:.|.|.|       :..||:..||:
Yeast   188 LDNLKSIKKDMSVDIKLLKQSVEHLKLDKDRSKAMKLNIHQLQTKID-------QYNEEVSEIES 245

  Fly   261 RLVEIRNVEFEIGKYQAQKVEMDTKHKNCK-------DQISTLT-----LKIKKPFRGTLDELDQ 313
            :|.||.....::.|......::.:|.:|.|       ||:..|:     |.:.||      :|..
Yeast   246 QLNEITEKSDKLFKSNQDFQKILSKVENLKNTKLSISDQVKRLSNSIDILDLSKP------DLQN 304

  Fly   314 EISNFDQRMLEMRQKRTEVEGDLSQIKRSSVAEQEKLGTQDRKHCLAKQ-----RHQSELACRAQ 373
            .::||.:.:::...:..::|.|:|.:|             ||:..|...     |.|.||....:
Yeast   305 LLANFSKVLMDKNNQLRDLETDISSLK-------------DRQSSLQSLSNSLIRRQGELEAGKE 356

  Fly   374 LLKRVKEFCRELHIPI-----------DCDLVEQPEKMGEVLRDIEAMIITKHCEITEIVEQNEK 427
            ..::.:.....|....           :.|:.:...:|.:    .:|.|..   ::|:.::|..|
Yeast   357 TYEKNRNHLSSLKEAFQHKFQGLSNIENSDMAQVNHEMSQ----FKAFISQ---DLTDTIDQFAK 414

  Fly   428 ADRSRQVKIDELRIELTKSEQSVTAQEKQRESSKRESETLGVEIKKIET-SMQDLKKLEKEINEV 491
            ..:.::..:.:|...:|...|::...:|.|.....:||.|..::|..:: |.||  .|..|:..:
Yeast   415 DIQLKETNLSDLIKSITVDSQNLEYNKKDRSKLIHDSEELAEKLKSFKSLSTQD--SLNHELENL 477

  Fly   492 NELYESATKNIDQQAIKDAIARK------KASIAENQIQFKKLDEQLTFLGSMAKLVAECSLKQK 550
             :.|:...::.:.:.|...:.:|      :..|.||||:  |..:::......|.|.|:..|.:|
Yeast   478 -KTYKEKLQSWESENIIPKLNQKIEEKNNEMIILENQIE--KFQDRIMKTNQQADLYAKLGLIKK 539

  Fly   551 ELDKKNQEVHRV--RSRHSDHFGKLFKEPITCNYRRS-MQVVYEKLRREIQELNEKANTQKLKEQ 612
            .::.|..|:.::  :.::.....::|  |:|..::|: :::.::||...:|: |...|.:|:
Yeast   540 SINTKLDELQKITEKLQNDSRIRQVF--PLTQEFQRADLEMDFQKLFINMQK-NIAINNKKM--- 598

  Fly   613 SYEIKRK--NLISDISRMEKELKDSE-----------ELIYQKCRSTPYDDLLERS----KTTIS 660
             :|:.|:  |.:.:::.:||:|:|::           |.:.:.|....|:|:||.:    ||.:.
Yeast   599 -HELDRRYTNALYNLNTIEKDLQDNQKSKEKVIQLLSENLPEDCTIDEYNDVLEETELSYKTALE 662

  Fly   661 KLQFDHGALKSSEALYKKYIQKMDEEPSCPLCHHNMTSDEACDLTSELTDEI---------QKLP 716
            .|:.....|:.:    :|.::..:.:..|.||.....::   ...|:|..|:         :.|.
Yeast   663 NLKMHQTTLEFN----RKALEIAERDSCCYLCSRKFENE---SFKSKLLQELKTKTDANFEKTLK 720

  Fly   717 DNITRAEKALKAEQIKYENLLQLKPTILKVKELKDSLPQKKEELK----KVEELLGDSVSEYETL 777
            |.:...::.|.:.::..::::.|.....|:...:..|.:.|||.|    |::||..||....:
Yeast   721 DTVQNEKEYLHSLRLLEKHIITLNSINEKIDNSQKCLEKAKEETKTSKSKLDELEVDSTKLKD-- 783

  Fly   778 IALIGEPTHNMELANS----MMGDMSLLDEALKDSARLTKDLDLQKGQLPASYDSSVSMDDLQAE 838
                     ..|||.|    ::...:.|::.|||....:|.:..:......|.|...::|:|:.:
Yeast   784 ---------EKELAESEIRPLIEKFTYLEKELKDLENSSKTISEELSIYNTSEDGIQTVDELRDQ 839

  Fly   839 KSKVSKELETERKELESAQNAVQQQMDALNRLREKK---NSLKDRQIHLREGLQSLPQ------- 893
            :.|::..|...||.:...      ||:...::||..   |.:|::::.:.|...||.|
Yeast   840 QRKMNDSLRELRKTISDL------QMEKDEKVRENSRMINLIKEKELTVSEIESSLTQKQNIDDS 898

  Fly   894 LKERLEKLNSFLTTVASEISELKAKIQPLKLNLRAAIEEKERLKKSESEKLAQLNSKYNSYKSTD 958
            ::.:.|.:|.    :.|.:.||:|:|..||   ....|.:..|.|.::|:..|:.:|    :.|.
Yeast   899 IRSKRENIND----IDSRVKELEARIISLK---NKKDEAQSVLDKVKNERDIQVRNK----QKTV 952

  Fly   959 HDIQRL--------NKEAEDYAK--LDLRNEIKKLDEIIMASKDKLRKLEAEISLKTDELETIKT 1013
            .||.||        |:..:..||  .:|:..||:|:    .:|.::.:|:.::.||::|:...|.
Yeast   953 ADINRLIDRFQTIYNEVVDFEAKGFDELQTTIKELE----LNKAQMLELKEQLDLKSNEVNEEKR 1013

  Fly  1014 ECSNQQTVERDLKDNRELKQLEDKEAKLRESCQVLDKQLGNLDFHSVSKEKVNLTKQRDKATVRK 1078
            :.::....|::||.|.||.:|:.:...:......||.|....:.....:|.:.|..:.:|.:...
Yeast  1014 KLADSNNEEKNLKQNLELIELKSQLQHIESEISRLDVQNAEAERDKYQEESLRLRTRFEKLSSEN 1078

  Fly  1079 GELLGQLGEIHSQVNKLQREIDEPRFKESLKNFRKANYEIEVTRLCIEDLGQYRLALEWALIQFH 1143
            ...||::.::.:|::.|..:: ...:|:..||:.|...|::......:|:..|..||:.|::::|
Yeast  1079 AGKLGEMKQLQNQIDSLTHQL-RTDYKDIEKNYHKEWVELQTRSFVTDDIDVYSKALDSAIMKYH 1142

  Fly  1144 SEKMEMINRLIREYWRKIYRGNDIDYIQVKTDEVSSDASADRRKTYNYRVVQSKNYSEIEMRGRC 1208
            ..||:.|||:|.|.|::.|.|.|||.|::::|||||..   :.|:||||||..|...|::|||||
Yeast  1143 GLKMQDINRIIDELWKRTYSGTDIDTIKIRSDEVSSTV---KGKSYNYRVVMYKQDVELDMRGRC 1204

  Fly  1209 SAGQRVLASLIIRLALAETFSSNCGVLALDEPTTNLDRANINSLCEALNCIVEERQSQSNFMLII 1273
            ||||:||||:||||||:|||.:||||:||||||||||..||.||.::|:.|:..|:.|.||.||:
Yeast  1205 SAGQKVLASIIIRLALSETFGANCGVIALDEPTTNLDEENIESLAKSLHNIINMRRHQKNFQLIV 1269

  Fly  1274 ITHDENFVSSLGKIT---SYHRVFRNEECKSVIRRVE 1307
            |||||.|:..:....   .:.:|.|::..||.|..|:
Yeast  1270 ITHDEKFLGHMNAAAFTDHFFKVKRDDRQKSQIEWVD 1306

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rad50	NP_726199.3	rad50	2..1295	CDD:129694	384/1387 (28%)
RAD50	NP_014149.1	rad50	2..1302	CDD:129694	387/1395 (28%)