Protein Alignment wrapper and MYOT

DIOPT Version :10

• Sequence 1: NP_477404.1
• Gene: wrapper / 37555
• FlyBaseID: FBgn0025878
• Length: 500
• Species: Drosophila melanogaster
• Sequence 2: NP_006781.1
• Gene: MYOT / 9499
• HGNCID: 12399
• Length: 498
• Species: Homo sapiens
• Alignment Length: 293
• Identity: 74/293 - (25%)
• Similarity: 109/293 - (37%)
• Gaps: 62/293 - (21%)

  Fly    69 RDDVALVDSR-----HPELPPPDRIMLWPNGSLQVANVQSSDTGDYYCEMNSDSGHVVQQHAIEV 128
            :||....||:     |..|..|            .:.|:|..|         ..|.|..|.||:.
Human   202 QDDSGAQDSQQHNSEHARLQVP------------TSQVRSRST---------SRGDVNDQDAIQE 245

  Fly   129 QLAPQVLIE-PSDLTEQRIGAIFEVVCEAQGVPQPVITWRLNGNVIQPQ-------SNTGNRQSL 185
            :..|...|: |.:::... |....:..:..|:|.|.::|.|||..:|..       |..| ..||
Human   246 KFYPPRFIQVPENMSIDE-GRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKG-LHSL 308

  Fly   186 ILEIKSRNQAGLIECVASNGVGEPAVANVYLHVLFSPEVSIPQPVVYTKL------GSRAHLECI 244
            |.|:...:.||...|||.|..|| |...|.|.||.......|. .:|...      |....|||.
Human   309 IFEVVRASDAGAYACVAKNRAGE-ATFTVQLDVLAKEHKRAPM-FIYKPQSKKVLEGDSVKLECQ 371

  Fly   245 VEAAPAATVKWFHHGLPVALGAHSTTHESELQTNRSVDHYVNAVRHMLVVKSVRNADMGQYECRA 309
            :.|.|...:.|..:...|           :..|:|...:..|..|..|::|.|...|.|.|...|
Human   372 ISAIPPPKLFWKRNNEMV-----------QFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSA 425

  Fly   310 SNQISVKSGS--VELTGR-----PMPCLFKINP 335
            .|:..|.:.:  :::|.|     |.|...::.|
Human   426 VNEAGVTTCNTRLDVTARPNQTLPAPKQLRVRP 458

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wrapper	NP_477404.1	IG_like	41..118	CDD:214653	10/53 (19%)
		Ig strand B	52..56	CDD:409353
		Ig strand C	64..68	CDD:409353
		Ig strand E	94..98	CDD:409353	0/3 (0%)
		Ig strand F	108..113	CDD:409353	0/4 (0%)
		Ig strand G	122..125	CDD:409353	1/2 (50%)
		Ig	133..219	CDD:472250	28/93 (30%)
		Ig strand B	150..154	CDD:409353	0/3 (0%)
		Ig strand C	163..167	CDD:409353	0/3 (0%)
		Ig strand E	183..187	CDD:409353	2/3 (67%)
		Ig strand F	197..202	CDD:409353	1/4 (25%)
		Ig strand G	211..214	CDD:409353	0/2 (0%)
		Ig_3	222..311	CDD:464046	21/94 (22%)
		FN3	339..431	CDD:238020
MYOT	NP_006781.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..46
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	64..151
		Necessary for interaction with ACTN1	79..150
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	202..241		12/59 (20%)
		Necessary for interaction with ACTA1. /evidence=ECO:0000269|PubMed:12499399	215..498		70/280 (25%)
		Necessary for interaction with FLNC	215..493		70/280 (25%)
		Ig	250..340	CDD:472250	28/92 (30%)
		Ig strand B	267..271	CDD:409353	0/3 (0%)
		Ig strand C	280..284	CDD:409353	0/3 (0%)
		Ig strand E	306..310	CDD:409353	2/3 (67%)
		Ig strand F	320..325	CDD:409353	1/4 (25%)
		Ig strand G	333..336	CDD:409353	0/2 (0%)
		IgI_Myotilin_C	349..440	CDD:409473	23/102 (23%)
		Ig strand A	349..352	CDD:409473	1/3 (33%)
		Ig strand A'	355..360	CDD:409473	0/4 (0%)
		Ig strand B	365..372	CDD:409473	3/6 (50%)
		Ig strand C	379..385	CDD:409473	1/5 (20%)
		Ig strand C'	386..389	CDD:409473	0/2 (0%)
		Ig strand D	396..402	CDD:409473	0/5 (0%)
		Ig strand E	405..415	CDD:409473	4/9 (44%)
		Ig strand F	419..427	CDD:409473	3/7 (43%)
		Ig strand G	429..440	CDD:409473	1/10 (10%)