DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment wrapper and klg

DIOPT Version :10

Sequence 1:NP_477404.1 Gene:wrapper / 37555 FlyBaseID:FBgn0025878 Length:500 Species:Drosophila melanogaster
Sequence 2:NP_524454.2 Gene:klg / 42707 FlyBaseID:FBgn0017590 Length:545 Species:Drosophila melanogaster


Alignment Length:467 Identity:132/467 - (28%)
Similarity:219/467 - (46%) Gaps:42/467 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 KFKSIPTTVKTYENDTVQLPCTLNTPFRYVRWHRDDVALVDSRHPELPPPDRIMLWPNGSLQVAN 100
            :|.|...|.:....||:.|||.:.....:|...|....::.:.:..:...:|:.|....:|::::
  Fly   102 RFLSRGHTYRAVVGDTLVLPCQVENLGNFVLLWRRGTNVLTASNIMVTRDERVRLIDGYNLEISD 166

  Fly   101 VQSSDTGDYYCEMNSDSGHVVQQHAIEVQLAPQV-LIEPSDLTEQRIGAIFEVVCEAQGVPQPVI 164
            ::..|.|||.|:: ||..:..|.|.:|:.:.|.| .|..|...:.|.|....:.|:..|.|.|.|
  Fly   167 LEPQDAGDYVCQI-SDKINRDQVHTVEILVPPSVRAIPTSGQLQARKGGPITLECKGSGNPVPSI 230

  Fly   165 TWRLNGNVIQPQSNTGNRQSLILEIKSRNQAGLIECVASNGVGEPAVANVYLHVLFSPEVSIPQP 229
            .|.......:..:..|:...|.||...|.|||:.:|.|.||||:|...::.|.||:.|::.:.:.
  Fly   231 YWTKKSGANKSTARIGDGPILTLEKLERQQAGVYQCTADNGVGDPVTVDMRLDVLYPPDIQVEKS 295

  Fly   230 VVYTKLGSRAHLECIVEAAPAATVKWFHHGLPVALGAHSTTHESELQTNRSVDHYVNAV---RHM 291
            .:::..|..|.|.|||.|.|.|||.|:.:..|:                :|.|..:.|.   |||
  Fly   296 WIHSGEGFEAKLVCIVFADPVATVSWYQNSFPI----------------QSTDRRIMATRANRHM 344

  Fly   292 LVVKSVRNADMGQYECRASNQISVKSGSVELTGRPMPCLFKINPGTQSSTSHVLVWQTESLLPIM 356
            |.::.::..|.|.|.|.|.|.:......:||:|||....|......:|..|:.|.|:.:|..|:.
  Fly   345 LTIRHIQQEDFGNYSCVADNSLGRSRKYMELSGRPGAAEFYSPKWGRSPDSYNLTWKIDSYPPLE 409

  Fly   357 EFKLKFRQIPSNNVTRQVRTNWTELTIPAQ---ATNGLIYITTYTLHGLQPASLYEVSVLARNSF 418
            |.:|.:|::..|. |.|....|.:..:..:   |:..|.:|.:||:..|.|...||..|.|:|.:
  Fly   410 EVRLLYRRVQMNE-TYQQPGRWHDFILTPEHRPASEPLTHIMSYTIKNLHPGGYYEAIVQAKNRY 473

  Fly   419 GWSDNSKIVRFATGGEVELPNYSTESELQDDFTEEDFHNEITQRSEVLSASMMFNSGSVNGRGGI 483
            ||::.|.|.:|..         :|.|:   |...||.....:.:|...|||:    ||:.|...:
  Fly   474 GWNEVSDIFQFVV---------ATNSQ---DIGPEDAEVVASSKSRSNSASI----GSLPGSTVL 522

  Fly   484 -SAFIYSLCLIN 494
             :|.:.:|.|.|
  Fly   523 HTALLLALALSN 534

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wrapperNP_477404.1 IG_like 41..118 CDD:214653 18/76 (24%)
Ig strand B 52..56 CDD:409353 1/3 (33%)
Ig strand C 64..68 CDD:409353 1/3 (33%)
Ig strand E 94..98 CDD:409353 1/3 (33%)
Ig strand F 108..113 CDD:409353 3/4 (75%)
Ig strand G 122..125 CDD:409353 1/2 (50%)
Ig 133..219 CDD:472250 27/86 (31%)
Ig strand B 150..154 CDD:409353 0/3 (0%)
Ig strand C 163..167 CDD:409353 1/3 (33%)
Ig strand E 183..187 CDD:409353 1/3 (33%)
Ig strand F 197..202 CDD:409353 1/4 (25%)
Ig strand G 211..214 CDD:409353 0/2 (0%)
Ig_3 222..311 CDD:464046 26/91 (29%)
FN3 339..431 CDD:238020 30/94 (32%)
klgNP_524454.2 IG_like 109..195 CDD:214653 21/86 (24%)
Ig strand B 118..122 CDD:409353 1/3 (33%)
Ig strand C 131..135 CDD:409353 1/3 (33%)
Ig strand E 160..164 CDD:409353 1/3 (33%)
Ig strand F 174..179 CDD:409353 3/4 (75%)
Ig strand G 188..191 CDD:409353 1/2 (50%)
Ig_3 196..270 CDD:464046 22/73 (30%)
Ig_3 287..364 CDD:464046 26/92 (28%)
FN3 392..486 CDD:238020 30/94 (32%)

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