Protein Alignment Oatp58Db and Slco2b1

DIOPT Version :8

• Sequence 1: NP_611658.3
• Gene: Oatp58Db / 37544
• FlyBaseID: FBgn0034715
• Length: 680
• Species: Drosophila melanogaster
• Sequence 2: XP_006229783.1
• Gene: Slco2b1 / 140860
• RGDID: 621391
• Length: 693
• Species: Rattus norvegicus
• Alignment Length: 656
• Identity: 179/657 (27%)
• Similarity: 292/657 (44%)
• Gaps: 106/657 (16%)

  Fly    48 FATAHMFVIVYGIASCFLAMAFTYFTGTITTMEKRFNIPTKISGLITVGNDISTVFSSAFLSYYA 112
            |.....||:.:.|......|...|...:|:|:||||.:.::.|||:...|::..:....|:||:.
  Rat    47 FQNIKFFVLCHSILQLAQLMISGYLKSSISTVEKRFGLSSQTSGLLAAFNEVGNISLILFVSYFG 111

  Fly   113 SRGHRPRWVALGLIIIAIFCLLMLTPHIFYGPGEEALRLTEEYGMSESFGASLNITEKNDSLCHE 177
            ||.||||.:..|.|::|:..|||..||....|........|:  .|:.|.|||.:..........
  Rat   112 SRVHRPRMIGCGAILVAVAGLLMALPHFISEPYRYDHSSPED--RSQDFEASLCLPTTMAPASAL 174

  Fly   178 KNSNCLER--AGDYTPIVLFFIAQFIGGIGCSLFYAPGLSYMDDNSASSKTPAMLSWSSFLRMLG 240
            .|.:|..|  ....|.:.:.|.||.:.|||.......|:||:||.:..|.:|..|.....:.|:|
  Rat   175 SNDSCSSRTETKHLTMVGIMFTAQTLLGIGGVPIQPFGISYIDDFAHHSNSPLYLGILFAITMMG 239

  Fly   241 PAMGFSMVSLCLRLYIDPFKKP----LITTNDPRWMGAWWIGWILLTFILTISAVFVGMFPKEMP 301
            |.:.:.:.||.||||:|..:.|    .:||.||||:||||:|:::...::.::|.....||:|||
  Rat   240 PGLAYGLGSLMLRLYVDIDRMPEGGINLTTKDPRWVGAWWLGFLISAGLVVLAASPYFFFPREMP 304

  Fly   302 RAK----ARRLKADGEEDIPLAGRSFQDMLDSLKRLAS-------------NKVYVYNMLASILY 349
            :.|    .|:....|...|...|.......:.||:.|.             .||:...:|.::.:
  Rat   305 KEKYELHFRQKVLAGGASIGSKGEELSSQHEPLKKQAGLPQIAPDLTVVQFIKVFPRVLLRTLRH 369

  Fly   350 LFGYMPYWI------------------FTPKYIEIQYRQSASTSTMATGTWALGFSAAGILISGY 396
                 |.::                  |.||::|.|:..:||.:.:..|...:..:..||::.|.
  Rat   370 -----PIFLLVVLSQVCTSSMVAGTATFLPKFLERQFSITASFANLLLGCLTIPLAIVGIVVGGV 429

  Fly   397 VISKYKPSARAMAAWNFVVDYLTVAG-MLCYVL------VGCDESDRA---NSLSIVPTGDS--- 448
            ::.:...|....:|       |.:.| :||.:|      :||.....|   ..|...| |.|
  Rat   430 LVKRLHLSPMQCSA-------LCLLGSLLCLLLSLPLFFIGCSTHHIAGITQDLGAQP-GPSLFP 486

  Fly   449 -CSASCVCEYVYYAPVC-SPENITFISACHAGCTDKAINEL---GKTIYTGCRCM---GNVSSII 505
             ||..|.|:...:.||| :...:.:.:.||||||.:.:.|.   .:..||.|.|:   |.:|:
  Rat   487 GCSEPCSCQSDDFNPVCDTSAYVEYTTPCHAGCTGRVVQEALDKSQVFYTNCSCVAGNGTISA-- 549

  Fly   506 SLSNVTSLASQSQIAMDGACPVDCNKQFLIFLAVMCFLKFVGATGRSSNLLLALRCVPSKDKTFS 570
                             |:|...|::..|.|:.::.....|.:...:.:.:|.||.|..:|||.:
  Rat   550 -----------------GSCESACSRLVLPFILLISLGAAVASITHTPSFMLILRGVKKEDKTLA 597

  Fly   571 LGFGSMVYSVLAFIPSPIVFGWMLDSYCLVWGKTCSSKGNCWIYDTKSLRYTM----------NL 625
            :|...|:..|||::|||::.|..:|:.|:.|..||..:..|..||...||...          :|
  Rat   598 VGMQFMLLRVLAWMPSPVIHGSAIDTTCVHWALTCGRRAVCRYYDHDLLRNRFIGLQFFFKSGSL 662

  Fly   626 VCASLI 631
            ||.:|:
  Rat   663 VCFALV 668

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Db	NP_611658.3	OATP	53..619	CDD:281175	172/628 (27%)
		MFS	55..>410	CDD:119392	108/396 (27%)
		KAZAL_SLC21	447..499	CDD:238650	19/63 (30%)
Slco2b1	XP_006229783.1	OATP	52..646	CDD:281175	172/628 (27%)
		MFS	58..>301	CDD:119392	80/245 (33%)
		KAZAL_SLC21	484..541	CDD:238650	18/57 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	1	0.900				E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010				D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910		0.684	Consistency score
TreeFam	0	0.000	Not matched by this tool.
	3	2.820