DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp58Db and Slco1a5

DIOPT Version :9

Sequence 1:	NP_611658.3	Gene:	Oatp58Db / 37544	FlyBaseID:	FBgn0034715	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	NP_001254636.1	Gene:	Slco1a5 / 108096	MGIID:	1351865	Length:	670	Species:	Mus musculus

Alignment Length:	717	Identity:	176/717 - (24%)
Similarity:	310/717 - (43%)	Gaps:	105/717 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 VADDEKRLNSSDTTCGFSIFRGPALQRFATAHMFVIVYGIASCFLAMAFTYFTGTITTMEKRFNI 85
            :.:.|||:.:....|            |:...||::....|....:::..|....:|.:|::|:|
Mouse     1 MGETEKRIATHGVRC------------FSKIKMFLLALTCAYVSKSLSGIYMNSMLTQIERQFDI 53

  Fly    86 PTKISGLITVGNDISTVFSSAFLSYYASRGHRPRWVALGLIIIAIFCLLMLTPHIFYGPGEEALR 150
            ||.|.|||....:|..:.....:||:.::.|||..:.:|.:|:.:.|.||..||...|
Mouse    54 PTSIVGLINGSFEIGNLLLIILVSYFGTKLHRPIMIGIGCVIMGLGCFLMSLPHFLMG------- 111

  Fly   151 LTEEYGMSESFGASLNITEKNDSLCHEKNSNCLERAGDYTPIV-----LFFIAQFIG----GIGC 206
               .|....:...:.|:: .|..||.|..:..|:...|....|     |.:|...:|    |||.
Mouse   112 ---RYEYETTISPTSNLS-SNSFLCMENRTQTLKPTQDPAECVKEMKSLMWIYVLVGNIIRGIGE 172

  Fly   207 SLFYAPGLSYMDDNSASSKTPAMLSWSSFLRMLGPAMGFSMVSLCLRLYIDP----FKKPLITTN 267
            :.....|:||::|.:.|..:|..:......:|:||.:|..:.|.|.|:|:|.    .....||..
Mouse   173 TPIMPLGISYIEDFAKSENSPLYIGILESGKMIGPIVGLLLGSFCARIYVDTGSVNTDDLTITPT 237

  Fly   268 DPRWMGAWWIGWILLTFILTISAVFVGMFPKEMPRA----KARRLKADGEEDIPLAGRS-----F 323
            |.||:||||||:::...:..::::....|||.:|:.    ...|.:.|.||......:.     .
Mouse   238 DTRWVGAWWIGFLVCAGVNILTSIPFFFFPKTLPKEGLQDNVDRTENDKEEKHREKAKEENRGIT 302

  Fly   324 QDMLDSLKRLASNKVYVYNMLASILYLFGYMPYWIFTPKYIEIQYRQSASTSTMATGTWALGFSA 388
            :|.|..:|.|:.|.:|:..:|.|:|.:..::..:.|.|||:|.||.:|.|...:..|...|....
Mouse   303 KDFLPFMKSLSCNPIYMLLILTSVLQINAFINMFTFLPKYLEQQYGKSTSEVVLLIGVCNLPPIC 367

  Fly   389 AGILISGYVISKYKPSARAMAAWNFVVDYLTVAGMLCYVLVGCDESDRANSLSIVPTG------- 446
            .|.|:.|:::.|::.:.:..|...|.:..........:.::.||....| .|:....|
Mouse   368 IGYLLIGFIMKKFRITVKKAAYMAFCLSLFEYLLSYFHFMISCDNFQVA-GLTTSYEGVQHPLYV 431

  Fly   447 -----DSCSASCVCEYVYYAPVCSPENITFISACHAGCTDKAINELGKTIYTGCRCM---GNVSS 503
                 ..|:..|.|....:.|||....::::|||.||| :|::......::..|.|:   ||.|:
Mouse   432 ENKVLADCNTRCSCLTNTWDPVCGDNGLSYMSACLAGC-EKSVGMGTHMVFQNCSCIQSSGNSSA 495

  Fly   504 IISLSNVTSLASQSQIAMDGACP--VDCNKQFLIFLAVMCFLKFVGATGRSSNLLLALRCVPSKD 566
            ::                 |.|.  .:|..:...||.:.....|:.:.......::.|||:.|::
Mouse   496 VL-----------------GLCKKGPECANKLQYFLIMSVIGSFIYSITAIPGYMVLLRCIKSEE 543

  Fly   567 KTFSLGFGSMVYSVLAFIPSPIVFGWMLDSYCLVWGK-TCSSKGNCWIYDTKSLRYTMNLVCAS- 629
            |:..:|..:....:.|.||:||.||.::|..||.||. .|...|.|.:|:..:.|....::.|:
Mouse   544 KSLGIGLHAFCTRIFAGIPAPIYFGALIDRTCLHWGTLKCGEPGACRMYNINNFRRIYLVLPAAL 608

  Fly   630 -----------LIFLGSFWNIGVWYHAK----DMKVFDEDEKTVQAKQSDDI-ELKEKPNDVVTK 678
                       ||.:..|...|..|.::    |||:      ||:..:..|: .:.:..||...|
Mouse   609 RGSSYLPAFFILILMRKFQLPGEMYSSETELADMKL------TVKKSECTDVHRIPKVENDGELK 667

  Fly   679 KK 680
            .|
Mouse   668 TK 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Db	NP_611658.3	OATP	53..619	CDD:281175	154/605 (25%)
		MFS	55..>410	CDD:119392	99/376 (26%)
		KAZAL_SLC21	447..499	CDD:238650	15/54 (28%)
Slco1a5	NP_001254636.1	oat	1..625	CDD:273279	163/665 (25%)
		MFS	23..>397	CDD:119392	101/384 (26%)
		KAZAL_SLC21	436..488	CDD:238650	15/52 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920