Protein Alignment Oatp58Db and Slco1a5

DIOPT Version :8

• Sequence 1: NP_611658.3
• Gene: Oatp58Db / 37544
• FlyBaseID: FBgn0034715
• Length: 680
• Species: Drosophila melanogaster
• Sequence 2: NP_001254636.1
• Gene: Slco1a5 / 108096
• MGIID: 1351865
• Length: 670
• Species: Mus musculus
• Alignment Length: 717
• Identity: 176/718 (25%)
• Similarity: 310/718 (43%)
• Gaps: 105/718 (15%)

  Fly    21 VADDEKRLNSSDTTCGFSIFRGPALQRFATAHMFVIVYGIASCFLAMAFTYFTGTITTMEKRFNI 85
            :.:.|||:.:....|            |:...||::....|....:::..|....:|.:|::|:|
Mouse     1 MGETEKRIATHGVRC------------FSKIKMFLLALTCAYVSKSLSGIYMNSMLTQIERQFDI 53

  Fly    86 PTKISGLITVGNDISTVFSSAFLSYYASRGHRPRWVALGLIIIAIFCLLMLTPHIFYGPGEEALR 150
            ||.|.|||....:|..:.....:||:.::.|||..:.:|.:|:.:.|.||..||...|
Mouse    54 PTSIVGLINGSFEIGNLLLIILVSYFGTKLHRPIMIGIGCVIMGLGCFLMSLPHFLMG------- 111

  Fly   151 LTEEYGMSESFGASLNITEKNDSLCHEKNSNCLERAGDYTPIV-----LFFIAQFIG----GIGC 206
               .|....:...:.|:: .|..||.|..:..|:...|....|     |.:|...:|    |||.
Mouse   112 ---RYEYETTISPTSNLS-SNSFLCMENRTQTLKPTQDPAECVKEMKSLMWIYVLVGNIIRGIGE 172

  Fly   207 SLFYAPGLSYMDDNSASSKTPAMLSWSSFLRMLGPAMGFSMVSLCLRLYIDP----FKKPLITTN 267
            :.....|:||::|.:.|..:|..:......:|:||.:|..:.|.|.|:|:|.    .....||..
Mouse   173 TPIMPLGISYIEDFAKSENSPLYIGILESGKMIGPIVGLLLGSFCARIYVDTGSVNTDDLTITPT 237

  Fly   268 DPRWMGAWWIGWILLTFILTISAVFVGMFPKEMPRA----KARRLKADGEEDIPLAGRS-----F 323
            |.||:||||||:::...:..::::....|||.:|:.    ...|.:.|.||......:.     .
Mouse   238 DTRWVGAWWIGFLVCAGVNILTSIPFFFFPKTLPKEGLQDNVDRTENDKEEKHREKAKEENRGIT 302

  Fly   324 QDMLDSLKRLASNKVYVYNMLASILYLFGYMPYWIFTPKYIEIQYRQSASTSTMATGTWALGFSA 388
            :|.|..:|.|:.|.:|:..:|.|:|.:..::..:.|.|||:|.||.:|.|...:..|...|....
Mouse   303 KDFLPFMKSLSCNPIYMLLILTSVLQINAFINMFTFLPKYLEQQYGKSTSEVVLLIGVCNLPPIC 367

  Fly   389 AGILISGYVISKYKPSARAMAAWNFVVDYLTVAGMLCYVLVGCDESDRANSLSIVPTG------- 446
            .|.|:.|:::.|::.:.:..|...|.:..........:.::.||....| .|:....|
Mouse   368 IGYLLIGFIMKKFRITVKKAAYMAFCLSLFEYLLSYFHFMISCDNFQVA-GLTTSYEGVQHPLYV 431

  Fly   447 -----DSCSASCVCEYVYYAPVCSPENITFISACHAGCTDKAINELGKTIYTGCRCM---GNVSS 503
                 ..|:..|.|....:.|||....::::|||.||| :|::......::..|.|:   ||.|:
Mouse   432 ENKVLADCNTRCSCLTNTWDPVCGDNGLSYMSACLAGC-EKSVGMGTHMVFQNCSCIQSSGNSSA 495

  Fly   504 IISLSNVTSLASQSQIAMDGACP--VDCNKQFLIFLAVMCFLKFVGATGRSSNLLLALRCVPSKD 566
            ::                 |.|.  .:|..:...||.:.....|:.:.......::.|||:.|::
Mouse   496 VL-----------------GLCKKGPECANKLQYFLIMSVIGSFIYSITAIPGYMVLLRCIKSEE 543

  Fly   567 KTFSLGFGSMVYSVLAFIPSPIVFGWMLDSYCLVWGK-TCSSKGNCWIYDTKSLRYTMNLVCAS- 629
            |:..:|..:....:.|.||:||.||.::|..||.||. .|...|.|.:|:..:.|....::.|:
Mouse   544 KSLGIGLHAFCTRIFAGIPAPIYFGALIDRTCLHWGTLKCGEPGACRMYNINNFRRIYLVLPAAL 608

  Fly   630 -----------LIFLGSFWNIGVWYHAK----DMKVFDEDEKTVQAKQSDDI-ELKEKPNDVVTK 678
                       ||.:..|...|..|.::    |||:      ||:..:..|: .:.:..||...|
Mouse   609 RGSSYLPAFFILILMRKFQLPGEMYSSETELADMKL------TVKKSECTDVHRIPKVENDGELK 667

  Fly   679 KK 680
            .|
Mouse   668 TK 669

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Db	NP_611658.3	OATP	53..619	CDD:281175	154/606 (25%)
		MFS	55..>410	CDD:119392	100/377 (27%)
		KAZAL_SLC21	447..499	CDD:238650	15/55 (27%)
Slco1a5	NP_001254636.1	oat	1..625	CDD:273279	163/666 (24%)
		MFS	23..>397	CDD:119392	101/385 (26%)
		KAZAL_SLC21	436..488	CDD:238650	15/53 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	1	0.900				E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010				D1029129at2759
OrthoFinder	1	1.000				FOG0000112
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910		0.684	Consistency score
RoundUp	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820