DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ari-2 and ARI8

DIOPT Version :9

Sequence 1:	NP_477374.1	Gene:	ari-2 / 37542	FlyBaseID:	FBgn0025186	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_176722.2	Gene:	ARI8 / 842854	AraportID:	AT1G65430	Length:	567	Species:	Arabidopsis thaliana

Alignment Length:	541	Identity:	155/541 - (28%)
Similarity:	238/541 - (43%)	Gaps:	100/541 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DSDIEMDMESDNDGEYDDDYDYYNTGEDCDVERLDPKRADPEYFEYECLTVEDIEKLLNERVEKL 66
            |||     |.|.||||:...|..:..:|....|...        .|..|:..||.||..:.:.::
plant    19 DSD-----EDDADGEYEFVDDAADDSDDLIFRRRQQ--------NYSVLSEADICKLQEDDISRI 70

  Fly    67 NTILQITPSLAKVLLLEHQW--NNV-----AVVEKYRQDANALLVTARIKPPSVAVTDTASTSAA 124
            :|:|.|:.:.:.:||..:.|  :.|     |..||.| ||..||....:..|:....|
plant    71 STVLSISRNSSAILLRHYNWCVSRVHDEWFADEEKVR-DAVGLLEKPVVDFPTDGELD------- 127

  Fly   125 AASAQLLRLGSSGYKTTASATPQYRSQMCPVCASSQLGDKFYSLACGHSFCKDCWTIYFETQIFQ 189
                                        |.:|..:.|.||.::.||||.||..||..|..|.|..
plant   128 ----------------------------CGICFETFLSDKLHAAACGHPFCDSCWEGYITTAIND 164

  Fly   190 GISTQIGCMA-----QMCNVRVPEDLVLTLVTRPVMRDKYQQFAFKDYVKSHPELRFCPGPNC-- 247
            |    .||:.     ..|...|.:|:: .|:.....:.||..:..:.||:.:.:.::||.|.|
plant   165 G----PGCLTLRCPDPSCRAAVGQDMI-NLLAPDKDKQKYTSYFVRSYVEDNRKTKWCPAPGCDY 224

  Fly   248 --QIIVQSSEISAKRAICKACHTGFCFRCGMDYHAPTDCQVIKKWLTKCADDSETANYISAHTKD 310
              ..:|.|......   |:.|:: ||:.|..:.|.|.||..:.||:.|.:.:||..|:|.|::|.
plant   225 AVNFVVGSGNYDVN---CRCCYS-FCWNCAEEAHRPVDCDTVSKWVLKNSAESENMNWILANSKP 285

  Fly   311 CPKCHICIEKNGGCNHMQCF-NCKHDFCWMCLGDWKTHGSE---YYECSRY----KDNPNIANES 367
            ||||...||||.||.|:.|. .||.:|||:|||.|..||.:   :|.|:||    :|......|.
plant   286 CPKCKRPIEKNQGCMHITCTPPCKFEFCWLCLGAWTEHGEKTGGFYACNRYEAAKQDGIYDETEK 350

  Fly   368 VHVQAREALKKYLHYYERWENHSKS-----LKLEQQTIDRLRQRINSKVMNGSGTWIDWQYLFNA 427
            ....|:.:|::|.||||||..:..|     |.|::...|.:.:..:.:....|    ..:::..|
plant   351 RREMAKNSLERYTHYYERWATNQSSRQKALLDLKKMQTDDIEKLSDIQCQPES----QLKFIIEA 411

  Fly   428 AALLAKCRYTLQYTYPYAYYM---EAGSRKNLFEYQQAQLEAEIENLSWKIERAETTDLGDLENQ 489
            ...:.:||..|::||.|.:|:   |.|.|. .|||.|.:.|:.:|.|....|:.....|......
plant   412 WLQIVECRRVLKWTYAYGFYIPDQEHGKRV-FFEYLQGEAESGLERLHQCAEKELLPYLDAKGPS 475

  Fly   490 MDIAEKRR-----TTLLKDFF 505
            .|..|.|.     |::.|::|
plant   476 EDFNEFRTKLAGLTSVTKNYF 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ari-2	NP_477374.1	RING-HC_RBR_TRIAD1	151..204	CDD:319687	20/57 (35%)
ari-2	NP_477374.1	IBR	222..284	CDD:214763	17/65 (26%)
ARI8	NP_176722.2	RING-HC_RBR_TRIAD1_like	128..178	CDD:319537	19/53 (36%)
		RING-HC finger (C3HC4-type)	128..178	CDD:319537	19/53 (36%)
		IBR	197..259	CDD:214763	17/65 (26%)
		IBR	<281..320	CDD:366672	22/38 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	64	1.000	Domainoid score	I3648
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54219
OrthoDB	1	1.010	-	-		D469819at2759
OrthoFinder	1	1.000	-	-		FOG0000379
OrthoInspector	1	1.000	-	-		mtm1045
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11685
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.990