Protein Alignment ari-2 and Cul7

DIOPT Version :9

• Sequence 1: NP_477374.1
• Gene: ari-2 / 37542
• FlyBaseID: FBgn0025186
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_079887.3
• Gene: Cul7 / 66515
• MGIID: 1913765
• Length: 1689
• Species: Mus musculus
• Alignment Length: 554
• Identity: 92/554 - (16%)
• Similarity: 150/554 - (27%)
• Gaps: 248/554 - (44%)

  Fly    64 EKLNTILQITPSLAKVLLLEHQ---WNNVAVVEKYRQDANALLVTARIKPPSVAVTDTASTSAAA 125
            ::|||: .:.||.::|.|||:.   |..:.:..|..|...   :..||:...|.
Mouse   897 KELNTV-NVMPSASRVTLLENLTRFWPIIQIRIKRCQQGG---INTRIRGLEVL----------- 946

  Fly   126 ASAQLLRLGSSGYKTTASATPQYRSQMCPVCASSQLGDKFYSLACGHSFCKDCWTIYFETQIFQG 190
                       |.|.|  ..|.:|.|:|.                             .|::|..
Mouse   947 -----------GPKPT--FWPVFREQLCR-----------------------------HTRLFYM 969

  Fly   191 ISTQIGCMAQMCNVRVPED----LVLTLVTRPVMRDKYQQFAFKDYVKSHPELRFCPGPNCQIIV 251
            :      .||..:..:.||    |.|:......:|.: |.||          .||.|
Mouse   970 V------RAQAWSQDIAEDRRSLLHLSSRLNGALRHE-QNFA----------ERFLP-------- 1009

  Fly   252 QSSEISAKRAICKACHTGFCFRCGMDYHAP-TDCQVIKKWLTK----CAD-----DSETANY--- 303
               ::.|.:|:.|.|..........:..:| .|......||..    |.:     .|..|.:
Mouse  1010 ---DMEAAQALSKTCWEALVSPLVQNITSPDEDSTSSLGWLLDQYLGCREAAYNPQSRAAAFSSR 1071

  Fly   304 --------ISAHTKDCPKCHICIEKNGGCNHMQCFNCKHDF------------------CWMCL- 341
                    :....::.....:.|.::.|.|.:      ||:                  ||..:
Mouse  1072 VRRLTHLLVHVEPREAAPPVVAIPRSKGRNRI------HDWSYLITRGLPSSIMKNLTRCWRSVV 1130

  Fly   342 ---------GDWKTHGSEYYECSRY----KDN-----PNIA------NESVHVQAREALKKYLHY 382
                     ..||........|.||    |.:     |..|      |.......|....:..|.
Mouse  1131 EEQMNKFLTASWKDDDFVPRYCERYYVLQKSSSELFGPRAAFLLAMRNGCADAVLRLPFLRAAHV 1195

  Fly   383 YERWENHSKSLKLEQQTIDRLRQRINSKVMNGSGTWIDWQYLFNAAALLAKCRYTLQ-------- 439
            .|::..|          ||   |||....|.|:          ....:||:.:..|:
Mouse  1196 SEQFARH----------ID---QRIQGSRMGGA----------RGMEMLAQLQRCLESVLIFSPL 1237

  Fly   440 -----YTYPYAYYM-----EAGS---------------------------------RKNLFEYQQ 461
                 :.:.|.:||     ..||                                 ::....||.
Mouse  1238 EIATTFEHYYQHYMADRLLSVGSSWLEGAVLEQIGPCFPSRLPQQMLQSLNVSEELQRQFHVYQL 1302

  Fly   462 AQLEAEIENLSWKIERAETTDLGDLENQMDIAEK 495
            .||:.|:..|.            |.|.::.:|.:
Mouse  1303 QQLDQELLKLE------------DTEKKIQVAHE 1324

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ari-2	NP_477374.1	RING-HC_RBR_TRIAD1	151..204	CDD:319687	6/52 (12%)
		IBR	222..284	CDD:214763	11/62 (18%)
Cul7	NP_079887.3	Interaction with TP53. /evidence=ECO:0000250	349..449
		Cul7	352..423	CDD:288381
		APC10-like	817..947	CDD:295192	15/75 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1321..1371		1/4 (25%)
		Cullin_Nedd8	1552..1630	CDD:299553

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469819at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010