Protein Alignment ari-2 and arih1l

DIOPT Version :10

• Sequence 1: NP_477374.1
• Gene: ari-2 / 37542
• FlyBaseID: FBgn0025186
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_998088.1
• Gene: arih1l / 405859
• ZFINID: ZDB-GENE-040426-2395
• Length: 533
• Species: Danio rerio
• Alignment Length: 546
• Identity: 174/546 - (31%)
• Similarity: 278/546 - (50%)
• Gaps: 79/546 - (14%)

  Fly     7 MDMESDNDGEYDDDYDYYNTGEDC-----------------DVERLDPKRA-------------- 40
            ||.:...:.|:||:.:.....|:|                 :||.|||..|
Zfish     1 MDSDEGYNYEFDDEEEEEEEEEECSVDSGEEEAVDDSLELGEVELLDPAVAGGEPDDCADTGGGG 65

  Fly    41 -----DPEYFEYECLTVEDIEKLLNERVEKLNTILQITPSLAKVLLLEHQWNNVAVVEKYRQDAN 100
                 :.|.:.:|.||.|.|.:.:.|.:..:|.::|...::.::||....|:...::|:| .|.|
Zfish    66 PGPGQEDEDYRFEVLTTEQILQHMVECIRDVNEVIQNPATITRILLSHFNWDKEKLMERY-FDGN 129

  Fly   101 --ALLVTARI----KPPSVAVTDTASTSAAAASAQLLRLGSSGYKTTASATPQYRSQMCPVCASS 159
              .|.....:    |.|......|.|:|                          :...|.:|..:
Zfish   130 LDKLFSECHVINPSKKPKTRPMSTRSSS--------------------------QDLPCQICYLN 168

  Fly   160 QLGDKFYSLACGHSFCKDCWTIYFETQIF-QGISTQIGCMAQMCNVRVPEDLVLTLVTRPVMRDK 223
            .....|..|.|||.||..||..|..|:|. :|:...|.|.|..|::.|.::.|:.|:|...::.|
Zfish   169 YPNSYFTGLECGHKFCMQCWGDYLTTKIIEEGMGQTISCPAHNCDILVDDNTVMRLITDSKVKLK 233

  Fly   224 YQQFAFKDYVKSHPELRFCPGPNCQIIVQSSEISAKRAICKACHTGFCFRCGMDYHAPTDCQVIK 288
            ||......:|:.:..|::||.|:|..:|:.....||...|| |...|||.||.::|.|..|:.::
Zfish   234 YQHLITNSFVECNRLLKWCPAPDCHHVVKVQYPDAKPVRCK-CGRQFCFNCGENWHDPVKCKWLR 297

  Fly   289 KWLTKCADDSETANYISAHTKDCPKCHICIEKNGGCNHMQC--FNCKHDFCWMCLGDWKTHGSEY 351
            ||:.||.|||||:|:|:|:||:|||||:.|||:||||||.|  .|||.:|||:|||.|:.|||.:
Zfish   298 KWIKKCDDDSETSNWIAANTKECPKCHVTIEKDGGCNHMVCRNQNCKAEFCWVCLGPWEPHGSAW 362

  Fly   352 YECSRYKDNPNIANESVHVQAREALKKYLHYYERWENHSKSLKLEQQTIDRLRQRINSKVMNGSG 416
            |.|:||.::...|......::|.||::||.|..|:.||.:||:.|.:...:::|:: .::...:.
Zfish   363 YNCNRYNEDDAKAARDAQERSRAALQRYLFYCNRYMNHMQSLRFEHKLYAQVKQKM-EEMQQHNM 426

  Fly   417 TWIDWQYLFNAAALLAKCRYTLQYTYPYAYYMEAGSRKNLFEYQQAQLEAEIENLSWKIERAETT 481
            :||:.|:|..|..:|.:||.||.:||.:|:|::..::..:||..||.||...|.||..:||..:.
Zfish   427 SWIEVQFLKKAVDVLCQCRSTLMFTYVFAFYLKKNNQSIIFENNQADLENATEVLSGYLERDISQ 491

  Fly   482 D-LGDLENQMD----IAEKRRTTLLK 502
            | |.|::.::.    ..|.||..||:
Zfish   492 DSLQDIKQKVQDKYRYCESRRRVLLQ 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ari-2	NP_477374.1	RING-HC_RBR_TRIAD1	152..204	CDD:438429	19/52 (37%)
		BRcat_RBR_TRIAD1	231..302	CDD:439005	29/70 (41%)
		Rcat_RBR_TRIAD1	306..361	CDD:439021	35/56 (63%)
		Ariadne	371..>477	CDD:466073	36/105 (34%)
arih1l	NP_998088.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..35		7/33 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	48..73		2/24 (8%)
		TRIAD supradomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU01221	158..369		91/211 (43%)
		RING-HC_RBR_HHARI	160..218	CDD:438288	20/57 (35%)
		BRcat_RBR_HHARI-like	227..308	CDD:439004	29/81 (36%)
		Rcat_RBR_HHARI-like	312..369	CDD:439017	35/56 (63%)
		Ariadne	370..>501	CDD:466073	42/131 (32%)