DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ari-2 and arih1l

DIOPT Version :9

Sequence 1:	NP_477374.1	Gene:	ari-2 / 37542	FlyBaseID:	FBgn0025186	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_998088.1	Gene:	arih1l / 405859	ZFINID:	ZDB-GENE-040426-2395	Length:	533	Species:	Danio rerio

Alignment Length:	546	Identity:	174/546 - (31%)
Similarity:	278/546 - (50%)	Gaps:	79/546 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 MDMESDNDGEYDDDYDYYNTGEDC-----------------DVERLDPKRA-------------- 40
            ||.:...:.|:||:.:.....|:|                 :||.|||..|
Zfish     1 MDSDEGYNYEFDDEEEEEEEEEECSVDSGEEEAVDDSLELGEVELLDPAVAGGEPDDCADTGGGG 65

  Fly    41 -----DPEYFEYECLTVEDIEKLLNERVEKLNTILQITPSLAKVLLLEHQWNNVAVVEKYRQDAN 100
                 :.|.:.:|.||.|.|.:.:.|.:..:|.::|...::.::||....|:...::|:| .|.|
Zfish    66 PGPGQEDEDYRFEVLTTEQILQHMVECIRDVNEVIQNPATITRILLSHFNWDKEKLMERY-FDGN 129

  Fly   101 --ALLVTARI----KPPSVAVTDTASTSAAAASAQLLRLGSSGYKTTASATPQYRSQMCPVCASS 159
              .|.....:    |.|......|.|:|                          :...|.:|..:
Zfish   130 LDKLFSECHVINPSKKPKTRPMSTRSSS--------------------------QDLPCQICYLN 168

  Fly   160 QLGDKFYSLACGHSFCKDCWTIYFETQIF-QGISTQIGCMAQMCNVRVPEDLVLTLVTRPVMRDK 223
            .....|..|.|||.||..||..|..|:|. :|:...|.|.|..|::.|.::.|:.|:|...::.|
Zfish   169 YPNSYFTGLECGHKFCMQCWGDYLTTKIIEEGMGQTISCPAHNCDILVDDNTVMRLITDSKVKLK 233

  Fly   224 YQQFAFKDYVKSHPELRFCPGPNCQIIVQSSEISAKRAICKACHTGFCFRCGMDYHAPTDCQVIK 288
            ||......:|:.:..|::||.|:|..:|:.....||...|| |...|||.||.::|.|..|:.::
Zfish   234 YQHLITNSFVECNRLLKWCPAPDCHHVVKVQYPDAKPVRCK-CGRQFCFNCGENWHDPVKCKWLR 297

  Fly   289 KWLTKCADDSETANYISAHTKDCPKCHICIEKNGGCNHMQC--FNCKHDFCWMCLGDWKTHGSEY 351
            ||:.||.|||||:|:|:|:||:|||||:.|||:||||||.|  .|||.:|||:|||.|:.|||.:
Zfish   298 KWIKKCDDDSETSNWIAANTKECPKCHVTIEKDGGCNHMVCRNQNCKAEFCWVCLGPWEPHGSAW 362

  Fly   352 YECSRYKDNPNIANESVHVQAREALKKYLHYYERWENHSKSLKLEQQTIDRLRQRINSKVMNGSG 416
            |.|:||.::...|......::|.||::||.|..|:.||.:||:.|.:...:::|:: .::...:.
Zfish   363 YNCNRYNEDDAKAARDAQERSRAALQRYLFYCNRYMNHMQSLRFEHKLYAQVKQKM-EEMQQHNM 426

  Fly   417 TWIDWQYLFNAAALLAKCRYTLQYTYPYAYYMEAGSRKNLFEYQQAQLEAEIENLSWKIERAETT 481
            :||:.|:|..|..:|.:||.||.:||.:|:|::..::..:||..||.||...|.||..:||..:.
Zfish   427 SWIEVQFLKKAVDVLCQCRSTLMFTYVFAFYLKKNNQSIIFENNQADLENATEVLSGYLERDISQ 491

  Fly   482 D-LGDLENQMD----IAEKRRTTLLK 502
            | |.|::.::.    ..|.||..||:
Zfish   492 DSLQDIKQKVQDKYRYCESRRRVLLQ 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ari-2	NP_477374.1	RING-HC_RBR_TRIAD1	151..204	CDD:319687	19/53 (36%)
ari-2	NP_477374.1	IBR	222..284	CDD:214763	22/61 (36%)
arih1l	NP_998088.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35		7/33 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	48..73		2/24 (8%)
		TRIAD supradomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01221	158..369		91/211 (43%)
		IBR	233..293	CDD:214763	22/60 (37%)
		IBR	<315..355	CDD:279784	27/39 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54219
OrthoDB	1	1.010	-	-		D429758at33208
OrthoFinder	1	1.000	-	-		FOG0000379
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X447
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.930