DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ari-2 and CG12362

DIOPT Version :9

Sequence 1:	NP_477374.1	Gene:	ari-2 / 37542	FlyBaseID:	FBgn0025186	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_648392.1	Gene:	CG12362 / 39193	FlyBaseID:	FBgn0036082	Length:	511	Species:	Drosophila melanogaster

Alignment Length:	526	Identity:	165/526 - (31%)
Similarity:	272/526 - (51%)	Gaps:	60/526 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSDIEMDMESDNDG----------EYDDDYDYYNTGEDCDVERLDPKRA---DPEYFEYECLTV 52
            |:|::|...|...|.          |.|.|      .||...|.|.|:.:   :.|.|.|:.|:|
  Fly     1 MNSEMEFSDEDHGDSHRSLLTHMSCENDSD------SEDTCTEILLPENSNSPETEDFVYKVLSV 59

  Fly    53 EDIEKLLNERVEKLNTILQITPSLAKVLLLEHQWNNVAVVEKY-RQDANALLVTARIKPP---SV 113
            :.|.:.....::::|.:|.:.|.:.:::|...:|:..::.|.| ..:.......|.:..|   .:
  Fly    60 DQIVQHQRNIIDEVNNVLNLPPQVTRIILNHFKWDKESLFENYFESNPKDFFQRAHVLNPFEKKI 124

  Fly   114 AVTDTASTSAAAASAQLLRLGSSGYKTTASATPQYRSQMCPVCASSQLGDKFYSLACGHSFCKDC 178
            .....||||.|.                        .|:|.:|..|  .|:...|.|||:||..|
  Fly   125 ERESAASTSCAI------------------------PQLCGICFCS--CDELIGLGCGHNFCAAC 163

  Fly   179 WTIYFETQ-IFQGISTQIGCMAQMCNVRVPEDLVLTLVTRPVMRDKYQQFAFKDYVKSHPELRFC 242
            |..|...: ..:|::..|.|.|..|.:.|.....|.|.....:.::|||.....:|:.:..:|:|
  Fly   164 WKQYLANKTCSEGLANTIKCPAANCEILVDYISFLKLADDSEVVERYQQLITNTFVECNMLMRWC 228

  Fly   243 PGPNCQIIVQSSEISAKRAICKACHTGFCFRCGMDYHAPTDCQVIKKWLTKCADDSETANYISAH 307
            |.|||...|::.....:..:||..|. |||.||.::|.|..|..:|||:.||.:||||:|:|:.:
  Fly   229 PAPNCSHAVKAVCAEPRAVLCKCGHE-FCFACGENWHEPASCSSLKKWVKKCLEDSETSNWIAQN 292

  Fly   308 TKDCPKCHICIEKNGGCNHMQCFN--CKHDFCWMCLGDWKTHGSEYYECSRYKDNPNIANESVHV 370
            ||:||||::.|||:||||||.|.|  |::||||:|||.|:.|||.:|.|:|:.:...........
  Fly   293 TKECPKCNVTIEKDGGCNHMVCKNPSCRYDFCWVCLGSWEPHGSSWYSCNRFDEEEAKQARLAQQ 357

  Fly   371 QAREALKKYLHYYERWENHSKSLKLEQQTIDRLRQRINSKVMNGSGTWIDWQYLFNAAALLAKCR 435
            :.|.::.:|||||.|:.||.:|||:|.:....::.:::.  |....:||:.|:|.:|..:|.:||
  Fly   358 KYRSSMARYLHYYNRYSNHMQSLKMENKLYSNIQAKMDD--MQEEMSWIEVQFLRDAVDVLCQCR 420

  Fly   436 YTLQYTYPYAYYMEAGSRKNLFEYQQAQLEAEIENLSWKIERAETT-DLGDLENQ-MDIA---EK 495
            .||.|:|.:|:|:...::|.:||..|..:|...|.||..:||..|. ::.:::.: :|::   :|
  Fly   421 TTLMYSYVFAFYLMNNNQKIIFEDNQKDMEMATEKLSECLEREITVKNIYEVKQKVLDLSHYCQK 485

  Fly   496 RRTTLL 501
            ||..||
  Fly   486 RRHVLL 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ari-2	NP_477374.1	RING-HC_RBR_TRIAD1	151..204	CDD:319687	19/53 (36%)
ari-2	NP_477374.1	IBR	222..284	CDD:214763	21/61 (34%)
CG12362	NP_648392.1	IBR	208..269	CDD:214763	21/61 (34%)
CG12362	NP_648392.1	IBR	273..331	CDD:279784	36/57 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446174
Domainoid	1	1.000	64	1.000	Domainoid score	I3648
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	241	1.000	Inparanoid score	I689
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D37036at33392
OrthoFinder	1	1.000	-	-		FOG0000379
OrthoInspector	1	1.000	-	-		mtm1176
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11685
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	8.000