DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ari-2 and Rnf217

DIOPT Version :9

Sequence 1:	NP_477374.1	Gene:	ari-2 / 37542	FlyBaseID:	FBgn0025186	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_001139821.1	Gene:	Rnf217 / 268291	MGIID:	3610311	Length:	515	Species:	Mus musculus

Alignment Length:	230	Identity:	60/230 - (26%)
Similarity:	90/230 - (39%)	Gaps:	47/230 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 MCPVCASSQLGDKFYS--LACGHSFCKDCWTIYFETQIFQGISTQIGCMAQMCNVRVPEDLVLTL 214
            ||.||    |.||...  ..|..:.|::|..||..:|:..| ..:|.|....|...:.|..|:..
Mouse   235 MCRVC----LEDKPIKPLPCCKKAVCEECLKIYLSSQVQLG-QVEIKCPVTECFEFLEETTVVYN 294

  Fly   215 VTRPVMRD--KYQQFAFKDYVKSHPELRFCPGPNCQ----------IIVQSSEISAKRAICKACH 267
            :|.   .|  ||:.|.....:.|..:    |.|.|:          |...|...|..:..|..|.
Mouse   295 LTH---EDSIKYKYFLELGRIDSSTK----PCPQCKHFTTFKKKGHIPTPSRSESRYKIQCPTCQ 352

  Fly   268 TGFCFRCGMDYHAPTDCQVIKK-------WLTKCADDSETANYISAHTKDCPKCHICIEKNGGCN 325
            ..:||:|...:|...:|:..||       |.::.......|       :.||||.|.|::..||:
Mouse   353 LIWCFKCHSPWHEGVNCKEYKKGDKLLRHWASEIEHGQRNA-------QKCPKCKIHIQRTEGCD 410

  Fly   326 HMQCFNCKHDFCWMCLGDWKTHGSEYYECSRYKDN 360
            ||.|..|..:||:.|       |..|.:...:.|:
Mouse   411 HMTCSQCNTNFCYRC-------GERYRQLRFFGDH 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ari-2	NP_477374.1	RING-HC_RBR_TRIAD1	151..204	CDD:319687	17/53 (32%)
ari-2	NP_477374.1	IBR	222..284	CDD:214763	17/73 (23%)
Rnf217	NP_001139821.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..125
		Tankyrase_bdg_C	<62..131	CDD:291973
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	147..189
		TRIAD supradomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01221	232..451		60/230 (26%)
		IBR	302..369	CDD:214763	16/70 (23%)
		IBR	<397..429	CDD:279784	15/38 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910