Protein Alignment Vps35 and VPS35

DIOPT Version :10

• Sequence 1: NP_726175.3
• Gene: Vps35 / 37536
• FlyBaseID: FBgn0034708
• Length: 822
• Species: Drosophila melanogaster
• Sequence 2: NP_012381.1
• Gene: VPS35 / 853287
• SGDID: S000003690
• Length: 944
• Species: Saccharomyces cerevisiae
• Alignment Length: 880
• Identity: 283/880 - (32%)
• Similarity: 433/880 - (49%)
• Gaps: 139/880 - (15%)

  Fly    36 AIGLARKQAFQMNHFLDKERMLDSLKCASTMLGELRTSVLSPKSYYELYMAVTNELCHLELYLSE 100
            ||.:.:::...||..|.:.::::||:..|.||.|||...||||.|||||:.:.:.|.:|..||.|
Yeast    10 AIAVIKQRTALMNRCLSQHKLMESLQHTSIMLTELRNPNLSPKKYYELYVIIFDSLTNLSTYLIE 74

  Fly   101 KIDKK---TDLYELVQYSHTIVPRLYLLITVGIVYIKNDPTLKRSILKDLVEMCRGVQHPLRGLF 162
            ...:.   .||||||||:..:||||||:||||..|:..:...|:.||||::|||||||:|:||||
Yeast    75 NHPQNHHLADLYELVQYTGNVVPRLYLMITVGTSYLTFNEAPKKEILKDMIEMCRGVQNPIRGLF 139

  Fly   163 LRNYLLQCTRNILPDVMVEENEHEGNVYDAIDFVLTNFAEMNKLWVRMQHQGHSSEKTRREKERE 227
            ||.||.|.|:.:||     |::...|    ..|::.||.||||||||:||||...|:..|.:||:
Yeast   140 LRYYLSQRTKELLP-----EDDPSFN----SQFIMNNFIEMNKLWVRLQHQGPLRERETRTRERK 195

  Fly   228 ELKILVGTNLVRLSQLESATLEIYQRLILPGILEQVVSCRDAIAQEYLMECIIQVFPDEFHLKTL 292
            ||:||||:.||||||:.....::|::.|||.|||||:.|||.::||||::.|.|||.||||||||
Yeast   196 ELQILVGSQLVRLSQIIDDNFQMYKQDILPTILEQVIQCRDLVSQEYLLDVICQVFADEFHLKTL 260

  Fly   293 DPFLKSCAQLETGVNVKNIIISLIERLAAYNQRSGKTSGNAIDAIIPAEVELFEVFSVQVANIVQ 357
            |..|::...|...|::..|:::|::||..|..|..:...||.......::::|..|...:..:..
Yeast   261 DTLLQTTLHLNPDVSINKIVLTLVDRLNDYVTRQLEDDPNATSTNAYLDMDVFGTFWDYLTVLNH 325

  Fly   358 TRMDMPLEDTISLQVALLSLAQKVYPDRVDYVDKVLGTTAQILQRMNMNNISHLLSVNQELSRLL 422
            .|.|:.|:..|.|..:::.|:.|.||:..|.::|:.....|..:.....|||      .|...|.
Yeast   326 ERPDLSLQQFIPLVESVIVLSLKWYPNNFDNLNKLFELVLQKTKDYGQKNIS------LESEHLF 384

  Fly   423 RICIDFYNNALTIIQLQNFCPLLEKFDYTSRKSLALYLV------MNIL---------------- 465
            .:.:.|.|:.|   ||.:..........||:|.....|:      .|||
Yeast   385 LVLLSFQNSKL---QLTSSTTAPPNSPVTSKKHFIFQLISQCQAYKNILALQSISLQKKVVNEII 446

  Fly   466 ------------DNET-------------LVPTADQADSLLTIITPLIKDDDTNKENGAAAGNTT 505
                        ||::             ::....|...||:|..|||........| .|:.:|.
Yeast   447 DILMDREVEEMADNDSESKLHPPGHSAYLVIEDKLQVQRLLSICEPLIISRSGPPAN-VASSDTN 510

  Fly   506 PDAEEF---AEEQG-----VVARFIHLMRSDEPDMQYKMLQTARKHLGNG--------------- 547
            .|...|   .||:.     :..:..||       :.:.|..|:||.....
Yeast   511 VDEVFFNRHDEEESWILDPIQEKLAHL-------IHWIMNTTSRKQTMKNKIQFSLEAQLEILLL 568

  Fly   548 -------GGQRLKHVLPPLVFAAYQLAFKYKAIAE--------------QDENWDKKCQKIVQYC 591
                   ||..:|:..|.::...::|..|.:.|.|              ...|..|:..|.|..|
Yeast   569 IKSSFIKGGINVKYTFPAIITNFWKLMRKCRMIQEYLLKKRPDNKTLLSHYSNLLKQMFKFVSRC 633

  Fly   592 HSTISALAKADLADLALRLYLQGALVIGEIGYTNHETVAYEFMTQAFSLYEDEISDSKAQLAAIT 656
            .:.|.........||.|:|.||.|::..::....   ::|:|.:|||:::|:.:||||.||.|:.
Yeast   634 INDIFNSCNNSCTDLILKLNLQCAILADQLQLNE---ISYDFFSQAFTIFEESLSDSKTQLQALI 695

  Fly   657 LIMSTFEQ-MSCFGEENAEPLRTNCALAASKLLKKPDQCRGVVACAALFWSGKQN--GEE----- 713
            .|..:.:: .|.:.|...:.|...|.|..||||||.||||.|..|:.|:|:.:.:  |||
Yeast   696 YIAQSLQKTRSLYKEAYYDSLIVRCTLHGSKLLKKQDQCRAVYLCSHLWWATEISNIGEEEGITD 760

  Fly   714 --MRDEKRTLDCLKKGARIASQCLDTGVQVQLYVELLNHYLFYFERGN---SLITVAMLNQLIAK 773
              .||.||.|:||::..|:|...:|.....:|.||:||..|:||..|:   :.|::..:|.||..
Yeast   761 NFYRDGKRVLECLQRSLRVADSIMDNEQSCELMVEILNRCLYYFIHGDESETHISIKYINGLIEL 825

  Fly   774 VNEELPNLEPSEETKQIESHYKNTLAHIRSRMESN 808
            :...|.:|:..:.:   .|...|:::.:....|:|
Yeast   826 IKTNLKSLKLEDNS---ASMITNSISDLHITGENN 857

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps35	NP_726175.3	Vps35	32..776	CDD:427414	277/846 (33%)
VPS35	NP_012381.1	Vps35	8..828	CDD:427414	277/846 (33%)