Protein Alignment Vps35 and VPS35A

DIOPT Version :10

• Sequence 1: NP_726175.3
• Gene: Vps35 / 37536
• FlyBaseID: FBgn0034708
• Length: 822
• Species: Drosophila melanogaster
• Sequence 2: NP_179370.2
• Gene: VPS35A / 816289
• AraportID: AT2G17790
• Length: 787
• Species: Arabidopsis thaliana
• Alignment Length: 797
• Identity: 334/797 - (41%)
• Similarity: 485/797 - (60%)
• Gaps: 57/797 - (7%)

  Fly    24 NGLDDQEKLLAEAIGLARKQAFQMNHFLDKERMLDSLKCASTMLGELRTSVLSPKSYYELYMAVT 88
            :|.:|:||.||......::.||.|...:|...:.|:||.::.||.|||||.|||..||:|||...
plant     4 DGSEDEEKWLAAGAAAFKQNAFYMQRAIDSNNLKDALKYSAQMLSELRTSKLSPHKYYDLYMRAF 68

  Fly    89 NELCHLELYLSEKIDK---KTDLYELVQYSHTIVPRLYLLITVGIVYIKNDPTLKRSILKDLVEM 150
            :||..||::..|:..:   ..:||||||::..|:||||||.|.|.||||......:.||||||||
plant    69 DELRKLEIFFMEETRRGCSVIELYELVQHAGNILPRLYLLCTAGSVYIKTKEAPAKEILKDLVEM 133

  Fly   151 CRGVQHPLRGLFLRNYLLQCTRNILPDVMVEENEHEGN---VYDAIDFVLTNFAEMNKLWVRMQH 212
            |||:||||||||||:||.|.:|:.|||:   .:|:||:   |.||::|||.||.|||||||||||
plant   134 CRGIQHPLRGLFLRSYLAQISRDKLPDI---GSEYEGDADTVIDAVEFVLLNFTEMNKLWVRMQH 195

  Fly   213 QGHSSEKTRREKEREELKILVGTNLVRLSQLESATLEIYQRLILPGILEQVVSCRDAIAQEYLME 277
            ||.:.||.||||||.||:.|||.||..|||||...|::|:..:||.:|||:|:|||.|||.||::
plant   196 QGPAREKERREKERGELRDLVGKNLHVLSQLEGVDLDMYRDTVLPRVLEQIVNCRDEIAQYYLID 260

  Fly   278 CIIQVFPDEFHLKTLDPFLKSCAQLETGVNVKNIIISLIERLAAYNQRSGKTSGNAIDA-IIP-- 339
            |||||||||:||:|||..|.:|.||:..|::..::..|:|||:.|         .|::| ::|
plant   261 CIIQVFPDEYHLQTLDVLLGACPQLQASVDIMTVLSRLMERLSNY---------AALNAEVLPYF 316

  Fly   340 AEVELFEVFSVQVANIVQTRMDMPLEDTISLQVALLSLAQKVYPDRVDYVDKVLGTTAQILQRMN 404
            .:||.|...:..:..:::.:.|||:...::|..:||.....|:|||:||.|:|||:..:.|....
plant   317 LQVEAFSKLNNAIGKVIEAQEDMPILSAVTLYSSLLKFTLHVHPDRLDYADQVLGSCVKQLSGKG 381

  Fly   405 MNNISHLLSVNQELSRLLRICIDFYNNALTIIQLQNFCPLLEKFDYTSRKSLALYLVMNILDNET 469
            ..:.:.   ..:||..||...::.||:.:|.::|.|:..::|..|..:::.:|..:|.:|:.|.|
plant   382 KIDDTR---ATKELVSLLSAPLEKYNDVVTALKLTNYPLVVEYLDTETKRIMATVIVRSIMKNNT 443

  Fly   470 LVPTADQADSLLTIITPLIKDDDTNKENGAAAGNTTPDAEEFAEEQGVVARFIHLMRSDEPDMQY 534
            |:.||::.::|..:|..:|.|.|  :..|...     |.::|.|||..||..||::.:|:|:..:
plant   444 LITTAEKVEALFELIKGIINDLD--EPQGLEV-----DEDDFQEEQNSVALLIHMLYNDDPEEMF 501

  Fly   535 KMLQTARKHLGNGGGQRLKHVLPPLVFAAYQLAFKYKAIAEQDENWDKKCQ----KIVQYCHSTI 595
            |::...:||...||.:|||..:||||.:..:|..:..  .|.|..:.|:..    ||.|:.:..|
plant   502 KIVNVLKKHFLTGGPKRLKFTIPPLVVSTLKLIRRLP--VEGDNPFGKEASVTATKIFQFLNQII 564

  Fly   596 SALAKADLADLALRLYLQGALVIGEIGYTNHETVAYEFMTQAFSLYEDEISDSKAQLAAITLIMS 660
            .||......|||.|||||.|....:   .:.|.:||||.|||:.|||:||||||||:.|:.||:.
plant   565 EALPNVPSPDLAFRLYLQCAEAADK---CDEEPIAYEFFTQAYILYEEEISDSKAQVTALQLIIG 626

  Fly   661 TFEQMSCFGEENAEPLRTNCALAASKLLKKPDQCRGVVACAALFWSGKQNGEEMRDEKRTLDCLK 725
            |.::|..||.||.:.|.......|:||||||||||.|.||:.|||  .::.|.::|.:|.|.|||
plant   627 TLQRMQVFGVENRDTLTHKATGYAAKLLKKPDQCRAVYACSHLFW--LEDRETIQDGERVLLCLK 689

  Fly   726 KGARIASQCL--------DTGVQVQLYVELLNHYLFYFERGNSLITVAMLNQLIAKV-NEELPNL 781
            :..:||:...        .|| .|.|::|:||.||:::|:|...|||..:..||..: |||....
plant   690 RALKIANSAQQVANTARGSTG-SVTLFIEILNKYLYFYEKGVPQITVESVESLIKLIKNEESMPS 753

  Fly   782 EPSEETKQIESHYKNTL 798
            :||     .||.:..||
plant   754 DPS-----AESFFATTL 765

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps35	NP_726175.3	Vps35	32..776	CDD:427414	321/765 (42%)
VPS35A	NP_179370.2	Vps35	12..747	CDD:427414	321/764 (42%)