Protein Alignment Vps35 and VPS35

DIOPT Version :10

• Sequence 1: NP_726175.3
• Gene: Vps35 / 37536
• FlyBaseID: FBgn0034708
• Length: 822
• Species: Drosophila melanogaster
• Sequence 2: NP_060676.2
• Gene: VPS35 / 55737
• HGNCID: 13487
• Length: 796
• Species: Homo sapiens
• Alignment Length: 809
• Identity: 491/809 - (60%)
• Similarity: 634/809 - (78%)
• Gaps: 24/809 - (2%)

  Fly    21 TMPNGLDDQEKLLAEAIGLARKQAFQMNHFLDKERMLDSLKCASTMLGELRTSVLSPKSYYELYM 85
            |..:..|:|||||.|||...:.|:|||...|||.:::|:||.||.||||||||:|||||||||||
Human     4 TQQSPQDEQEKLLDEAIQAVKVQSFQMKRCLDKNKLMDALKHASNMLGELRTSMLSPKSYYELYM 68

  Fly    86 AVTNELCHLELYLSE---KIDKKTDLYELVQYSHTIVPRLYLLITVGIVYIKNDPTLKRSILKDL 147
            |:::||.:||:||::   |..|..||||||||:..|:||||||||||:||:|:.|..::.|||||
Human    69 AISDELHYLEVYLTDEFAKGRKVADLYELVQYAGNIIPRLYLLITVGVVYVKSFPQSRKDILKDL 133

  Fly   148 VEMCRGVQHPLRGLFLRNYLLQCTRNILPDV-MVEENEHEGNVYDAIDFVLTNFAEMNKLWVRMQ 211
            ||||||||||||||||||||||||||||||. ...:.|..|::.|::||||.|||||||||||||
Human   134 VEMCRGVQHPLRGLFLRNYLLQCTRNILPDEGEPTDEETTGDISDSMDFVLLNFAEMNKLWVRMQ 198

  Fly   212 HQGHSSEKTRREKEREELKILVGTNLVRLSQLESATLEIYQRLILPGILEQVVSCRDAIAQEYLM 276
            |||||.::.:||:||:||:||||||||||||||...:|.|::::|.|||||||:||||:||||||
Human   199 HQGHSRDREKRERERQELRILVGTNLVRLSQLEGVNVERYKQIVLTGILEQVVNCRDALAQEYLM 263

  Fly   277 ECIIQVFPDEFHLKTLDPFLKSCAQLETGVNVKNIIISLIERLAAYNQRSGKTSGNAIDAIIPAE 341
            |||||||||||||:||:|||::||:|...||||||||:||:|||.:..|.....       |||:
Human   264 ECIIQVFPDEFHLQTLNPFLRACAELHQNVNVKNIIIALIDRLALFAHREDGPG-------IPAD 321

  Fly   342 VELFEVFSVQVANIVQTRMDMPLEDTISLQVALLSLAQKVYPDRVDYVDKVLGTTAQILQRMNMN 406
            ::||::||.|||.::|:|.|||.||.:||||:|::||.|.||||||||||||.||.:|..::|:.
Human   322 IKLFDIFSQQVATVIQSRQDMPSEDVVSLQVSLINLAMKCYPDRVDYVDKVLETTVEIFNKLNLE 386

  Fly   407 NISHLLSVNQELSRLLRICIDFYNNALTIIQLQNFCPLLEKFDYTSRKSLALYLVMNILDNETLV 471
            :|:...:|::||:|||:|.:|.|||.||:::|::|.||.|.|||.||||::.|::.|:||..|.:
Human   387 HIATSSAVSKELTRLLKIPVDTYNNILTVLKLKHFHPLFEYFDYESRKSMSCYVLSNVLDYNTEI 451

  Fly   472 PTADQADSLLTIITPLIKDD-DTNKENGAAAGNTTPDAEEFAEEQGVVARFIHLMRSDEPDMQYK 535
            .:.||.||::.:::.||:|. |...|:        ||.|:||:||.:|.|||||:||::||.||.
Human   452 VSQDQVDSIMNLVSTLIQDQPDQPVED--------PDPEDFADEQSLVGRFIHLLRSEDPDQQYL 508

  Fly   536 MLQTARKHLGNGGGQRLKHVLPPLVFAAYQLAFKYKAIAEQDENWDKKCQKIVQYCHSTISALAK 600
            :|.|||||.|.||.||::..|||||||||||||:||..::.|:.|:||||||..:.|.|||||.|
Human   509 ILNTARKHFGAGGNQRIRFTLPPLVFAAYQLAFRYKENSKVDDKWEKKCQKIFSFAHQTISALIK 573

  Fly   601 ADLADLALRLYLQGALVIGEIGYTNHETVAYEFMTQAFSLYEDEISDSKAQLAAITLIMSTFEQM 665
            |:||:|.|||:|||||..||||:.||||||||||:|||||||||||||||||||||||:.|||:|
Human   574 AELAELPLRLFLQGALAAGEIGFENHETVAYEFMSQAFSLYEDEISDSKAQLAAITLIIGTFERM 638

  Fly   666 SCFGEENAEPLRTNCALAASKLLKKPDQCRGVVACAALFWSGK---QNGEEMRDEKRTLDCLKKG 727
            .||.|||.|||||.||||||||||||||.|.|..||.|||||:   :||||:...||.::||||.
Human   639 KCFSEENHEPLRTQCALAASKLLKKPDQGRAVSTCAHLFWSGRNTDKNGEELHGGKRVMECLKKA 703

  Fly   728 ARIASQCLDTGVQVQLYVELLNHYLFYFERGNSLITVAMLNQLIAKVNEELPNLEPSEETKQIES 792
            .:||:||:|..:||||::|:||.|::::|:.|..:|:.:|||||.|:.|:|||||.||||:||..
Human   704 LKIANQCMDPSLQVQLFIEILNRYIYFYEKENDAVTIQVLNQLIQKIREDLPNLESSEETEQINK 768

  Fly   793 HYKNTLAHIRSRMESNDSSLEVSFAGITL 821
            |:.|||.|:|.|.||.:|...: :.|:.|
Human   769 HFHNTLEHLRLRRESPESEGPI-YEGLIL 796

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps35	NP_726175.3	Vps35	32..776	CDD:427414	462/751 (62%)
VPS35	NP_060676.2	Vps35	15..752	CDD:427414	462/751 (62%)
		Interaction with SNX3. /evidence=ECO:0000269|PubMed:24344282	25..44		8/18 (44%)
		Interaction with SNX3. /evidence=ECO:0000269|PubMed:24344282	205..215		4/9 (44%)
		Interaction with SLC11A2. /evidence=ECO:0000269|PubMed:24344282	438..796		215/366 (59%)
		Interaction with IGF2R cytoplasmic domain. /evidence=ECO:0000269|PubMed:15078903	500..693		136/192 (71%)