Protein Alignment Vps35 and vps-35

DIOPT Version :10

• Sequence 1: NP_726175.3
• Gene: Vps35 / 37536
• FlyBaseID: FBgn0034708
• Length: 822
• Species: Drosophila melanogaster
• Sequence 2: NP_495180.2
• Gene: vps-35 / 174000
• WormBaseID: WBGene00006933
• Length: 821
• Species: Caenorhabditis elegans
• Alignment Length: 818
• Identity: 357/818 - (43%)
• Similarity: 530/818 - (64%)
• Gaps: 44/818 - (5%)

  Fly    28 DQEKLLAEAIGLARKQAFQMNHFLDKERMLDSLKCASTMLGELRTSVLSPKSYYELYMAVTNELC 92
            ||||.|.::|.:.:.::|:|...|||.:.:|:||.|..||.|:||:.||||.||.|||...:||.
 Worm    10 DQEKFLDQSIRVVKAESFEMKRCLDKGKTMDALKHALQMLNEMRTAELSPKFYYRLYMDSMHELQ 74

  Fly    93 HLELYL----SEKIDKKTDLYELVQYSHTIVPRLYLLITVGIVYIKNDPTLKRSILKDLVEMCRG 153
            .||:.|    :::..|..:|||.|||:..|:||||||:|:|.|:||.....::.|||||||||||
 Worm    75 CLEVNLVQEYAQEPAKLGNLYECVQYASAIIPRLYLLVTIGGVFIKCGLGSRKEILKDLVEMCRG 139

  Fly   154 VQHPLRGLFLRNYLLQCTRNILPD------VMVEENEH-----------EGNVYDAIDFVLTNFA 201
            ||||||||||||||:||||::|||      ::|..|::           :|.|.|.|||||.|||
 Worm   140 VQHPLRGLFLRNYLMQCTRSVLPDFPETEEMLVAHNDNLSKGTPKLKPRDGTVDDTIDFVLINFA 204

  Fly   202 EMNKLWVRMQHQGHSSEKTRREKEREELKILVGTNLVRLSQLESATLEIYQRLILPGILEQVVSC 266
            |||||||||||||.|.||.:|||:|.||:||||||||||:|||:.|.|:|.:.:||.||||:|||
 Worm   205 EMNKLWVRMQHQGPSKEKEKREKDRMELRILVGTNLVRLAQLEALTEEMYVKDVLPSILEQIVSC 269

  Fly   267 RDAIAQEYLMECIIQVFPDEFHLKTLDPFLKSCAQLETGVNVKNIIISLIERLAAYNQRSGKTSG 331
            ||.|:|||||||:||||.|:|||.||..||.:|.||:..||:|.::|:|::|||.|.     ||.
 Worm   270 RDPISQEYLMECVIQVFADDFHLATLTEFLNACGQLQQDVNIKILLIALVDRLALYT-----TSY 329

  Fly   332 NAIDAIIPAEVELFEVFSVQVANIVQTRMDMPLEDTISLQVALLSLAQKVYPDRVDYVDKVLGTT 396
            |. ....|.:::|||:||.|...:::.|.||||:|.::|.|:|:|||.|.||||.||.:......
 Worm   330 NE-GQPAPTKMQLFEIFSEQATTLIKNRPDMPLDDIVALHVSLVSLAVKCYPDRQDYANMTFQGL 393

  Fly   397 AQILQRMNMNNISHLLSVNQELSRLLRICIDFYNNALTIIQLQNFCPLLEKFDYTSRKSLALYLV 461
            .|:::...:.:|.....|.:||::||.|.||.|.|.|.:.||..:..::..|||..:.::|.|::
 Worm   394 RQVIEEKGVTDIEAFGKVGRELTKLLNIPIDEYKNVLRLSQLPEYIKVMNYFDYRGQCNIASYMI 458

  Fly   462 MNILDNETLVPTADQADSLLTIITPLIKDDDTNKENGAAAGNTTPDAEEFAEEQGVVARFIHLMR 526
            .|:|:.||:....|..||..::|:.|:||.:....:       :.:.||||:||.:|||.:||:|
 Worm   459 QNMLEEETVFRNQDDVDSAFSLISSLLKDQEKQSSD-------SHETEEFADEQNLVARLLHLIR 516

  Fly   527 SDEPDMQYKMLQTARKHLGNGGGQRLKHVLPPLVFAAYQLAFKYKAIAEQDENWDKKCQKIVQYC 591
            :|:.|.|:.:|.:|||.||.||..||::.|||::|..|:|..::..:.::|:.||.|.:|:....
 Worm   517 ADDVDSQFLLLNSARKTLGEGGRHRLRYTLPPIIFELYRLVLQFSDMKDEDDKWDAKIRKMFVCA 581

  Fly   592 HSTISAL-AKADLADLALRLYLQGALVIGEIGYTNHETVAYEFMTQAFSLYEDEISDSKAQLAAI 655
            ..||.|| :.|:||:|.::|||.||:....:.:.::.||.|||:::|.|:.||::.||:.::..:
 Worm   582 MGTIGALVSTAELAELPMKLYLNGAITADRVPFEDNHTVVYEFVSKALSILEDDVVDSRDRVRCL 646

  Fly   656 TLIMSTFEQMSCFGEENAEPLRTNCALAASKLLKKPDQCRGVVACAALFWSG---KQNGEEMRDE 717
            .|.:.|..:.:...|||.:||.....|||:|:.|||||.|.:|..|||:|.|   :.|||:|::.
 Worm   647 HLTVGTLLKTTHLPEENWQPLANQTVLAAAKMFKKPDQVRSLVTVAALYWHGQTLETNGEKMKNG 711

  Fly   718 KRTLDCLKKGARIASQCLDTGVQVQLYVELLNHYLFYFERGNSLITVAMLNQLIAKVNEELPNLE 782
            |:.:|.|:|.|:||.:||:..||.||:::||:.|.:|:|...|.:.|..:.:|||:..:....|:
 Worm   712 KKVVDILRKAAKIARECLEPLVQQQLFIQLLSAYTYYYEDNCSEVNVDHIEELIARTQDNAVQLD 776

  Fly   783 PSEETKQIESHYKNTLAHIRSRMESNDSSLEVSFAGIT 820
            .|.|...:|......:..::.      :.|:|:.|..|
 Worm   777 VSAEADSLEKQLGEAIRRLQL------AKLDVAAAQAT 808

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps35	NP_726175.3	Vps35	32..776	CDD:427414	345/768 (45%)
vps-35	NP_495180.2	Vps35	14..770	CDD:427414	345/768 (45%)