Protein Alignment Vps35 and Vps35

DIOPT Version :10

• Sequence 1: NP_726175.3
• Gene: Vps35 / 37536
• FlyBaseID: FBgn0034708
• Length: 822
• Species: Drosophila melanogaster
• Sequence 2: XP_061507942.1
• Gene: Vps35 / 1269546
• VectorBaseID: AGAMI1_002999
• Length: 829
• Species: Anopheles gambiae
• Alignment Length: 835
• Identity: 622/835 - (74%)
• Similarity: 721/835 - (86%)
• Gaps: 19/835 - (2%)

  Fly     1 MYPWSSSSYGGQ--IPSAANVRTMPNGLDDQEKLLAEAIGLARKQAFQMNHFLDKERMLDSLKCA 63
            ||.|:|::....  ...::..:|..|.:|:|:|||.||:.:.|.|:|||..||||:|::::::||
Mosquito     1 MYLWNSANLDNSALYRQSSQPQTPINSVDEQDKLLTEAMTVVRAQSFQMKRFLDKDRLMEAMRCA 65

  Fly    64 STMLGELRTSVLSPKSYYELYMAVTNELCHLELYLSEKID---KKTDLYELVQYSHTIVPRLYLL 125
            ||||||||||:||||||||||||:|:||.|.|.||.::..   |..||||.|||:..||||||||
Mosquito    66 STMLGELRTSLLSPKSYYELYMAITDELRHFEHYLLDEFQKGRKVPDLYEHVQYAGNIVPRLYLL 130

  Fly   126 ITVGIVYIKNDPTLKRSILKDLVEMCRGVQHPLRGLFLRNYLLQCTRNILPDVM---VEENEHEG 187
            ||||:||||.:..|||||||||||||||||||||||||||||||||||||||.|   ...:|:||
Mosquito   131 ITVGLVYIKTNSALKRSILKDLVEMCRGVQHPLRGLFLRNYLLQCTRNILPDTMHVGASGDENEG 195

  Fly   188 NVYDAIDFVLTNFAEMNKLWVRMQHQGHSSEKTRREKEREELKILVGTNLVRLSQLESATLEIYQ 252
            .|.|||||||||||||||||||:||||||||:.||||||||||||||||||||||||||||:|||
Mosquito   196 TVIDAIDFVLTNFAEMNKLWVRIQHQGHSSERARREKEREELKILVGTNLVRLSQLESATLDIYQ 260

  Fly   253 RLILPGILEQVVSCRDAIAQEYLMECIIQVFPDEFHLKTLDPFLKSCAQLETGVNVKNIIISLIE 317
            |||||||||||||||||||||||||||||||||||||:||||||||||||:.||||||||||||:
Mosquito   261 RLILPGILEQVVSCRDAIAQEYLMECIIQVFPDEFHLQTLDPFLKSCAQLQPGVNVKNIIISLID 325

  Fly   318 RLAAYNQRSGK---TSGNAIDAI--IPAEVELFEVFSVQVANIVQTRMDMPLEDTISLQVALLSL 377
            |||.||||:||   ||....:.|  |||||:||||||.|:|||||.|.|||:|||:||||||:||
Mosquito   326 RLALYNQRNGKVTQTSAGTTEIISAIPAEVQLFEVFSTQIANIVQLRTDMPMEDTVSLQVALVSL 390

  Fly   378 AQKVYPDRVDYVDKVLGTTAQILQRMNMNNISHLLSVNQELSRLLRICIDFYNNALTIIQLQNFC 442
            ||||||||||||||||.||||||.|:.::||||.||||||||||||:|:|||||.|||:||:.|.
Mosquito   391 AQKVYPDRVDYVDKVLETTAQILDRLKLSNISHSLSVNQELSRLLRLCVDFYNNILTILQLKFFT 455

  Fly   443 PLLEKFDYTSRKSLALYLVMNILDNETLVPTADQADSLLTIITPLIKDDDTNKENGAAAGNTTPD 507
            ||||||||||||:||||:|||:|:||||||||:|.||:||||:|||:|.|....:..|      :
Mosquito   456 PLLEKFDYTSRKALALYIVMNVLENETLVPTAEQVDSVLTIISPLIRDQDDQPADVRA------N 514

  Fly   508 AEEFAEEQGVVARFIHLMRSDEPDMQYKMLQTARKHLGNGGGQRLKHVLPPLVFAAYQLAFKYKA 572
            .|:|||:||:|.||:||:|||:||.|||:|..||||.|.||..|:::|||||||.|||||:|||:
Mosquito   515 MEDFAEDQGIVGRFVHLLRSDDPDTQYKILIAARKHFGTGGQHRIRYVLPPLVFQAYQLAYKYKS 579

  Fly   573 IAEQDENWDKKCQKIVQYCHSTISALAKADLADLALRLYLQGALVIGEIGYTNHETVAYEFMTQA 637
            ||.:||.||||||||:|:|||||:.|||::|.:||||:||||||.||:|.|||||.|||:|||||
Mosquito   580 IAAEDEMWDKKCQKILQFCHSTIAVLAKSELPELALRMYLQGALCIGQIAYTNHEAVAYDFMTQA 644

  Fly   638 FSLYEDEISDSKAQLAAITLIMSTFEQMSCFGEENAEPLRTNCALAASKLLKKPDQCRGVVACAA 702
            ||||||||||||:|.||||||:||.|||:||.|||||||||:||||||||||||||||.||.||:
Mosquito   645 FSLYEDEISDSKSQFAAITLIISTVEQMTCFTEENAEPLRTSCALAASKLLKKPDQCRAVVTCAS 709

  Fly   703 LFWSGKQNGEEMRDEKRTLDCLKKGARIASQCLDTGVQVQLYVELLNHYLFYFERGNSLITVAML 767
            |||||||||:|:|||||||:||||.|:|||||||.|||:||||||||||:|||.|||:.|||:||
Mosquito   710 LFWSGKQNGQELRDEKRTLECLKKAAKIASQCLDVGVQLQLYVELLNHYIFYFTRGNTQITVSML 774

  Fly   768 NQLIAKVNEELPNLEPSEETKQIESHYKNTLAHIRSRMESNDSSLEVSFAGITLN 822
            ||||||:|||||||||:|||||||.||:||||||||||||.|:.:|.||||||||
Mosquito   775 NQLIAKINEELPNLEPTEETKQIEMHYQNTLAHIRSRMESTDAGIEASFAGITLN 829

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps35	NP_726175.3	Vps35	32..776	CDD:427414	573/754 (76%)
Vps35	XP_061507942.1	None